Table 3 EMOD intervention descriptions

Insecticide-treated nets (ITNs)

Distributed annually on January 1st;

Initial blocking 90%, decaying exponentially with a 2-year half-life;

Initial killing 60%, decaying exponentially with a 4-year half-life;

Nets are discarded with exponential decay and a 6-month half-life;

A randomly-selected 10% of the population never receives a net;

Everyone who owns a net uses it every night.

Indoor residual spraying (IRS)

Distributed annually on January 1st;

Initial killing 60%, decaying exponentially with a 6-month half-life;

No correlation between IRS and ITN coverage.

Artemether-Lumefantrine (AL) case management

Constant throughout simulation;

“Coverage” refers to the probability of seeking care given a clinical case;

Upon deciding to seek care, per-day probability of care-seeking is 0.15;

No age dependence;

Drugs clear infection and provide about two weeks of additional protection.

Dihydro-artemisinin-Piperaquine (DP) case management

Constant throughout simulation;

Same as AL case management, but with 1 month of protection after use.

Pre-Erythrocytic vaccine (PEV)

Constant throughout simulation;

90% acquisition blocking, decaying exponentially;

6- and 12- month decay half-lives;

Distributed to infants upon reaching 6 months of age.

Transmission-blocking vaccine (TBV)

Distributed annually on January 1st;

90% transmission blocking, decaying exponentially;

6- and 12- month decay half-lives;

Distributed to adults age 15-49.

Attractive targeted sugar baits (ATSB)

Distributed twice per year on January 1st and July 1st;

Reported in terms of per-feed mortality rate, not coverage;

6-month box duration of efficacy.

Monoclonal antibodies (mABs)

Distributed annually on January 1st;

Simulated via a PEV (see parameters above);

Distributed to adults age 15-49;

3-month box duration of protection.