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Fig. 7 | Malaria Journal

Fig. 7

From: The ability of Interleukin–10 to negate haemozoin-related pro-inflammatory effects has the potential to restore impaired macrophage function associated with malaria infection

Fig. 7

Impairment of malaria-specific T- cell function due to P. falciparum: IFN-γ and TNF producing CD3 + T cells were checked by flow cytometry for children with uncomplicated malaria (UCM), severe malarial anaemia (SMA) or cerebral malaria (CM), and healthy aparasitaemic children (Control). The cells were stimulated with phorbol myristate acetate/Ionomycin (7A and 7B) as a positive control, and P. falciparum schizonts lysate (7C and 7D) prior to cytokine measurements. IFN-γ- expressing CD3 + T cells (7A and 7C) and TNF-α- expressing CD3 + T cells (7B and 7D) in controls and different malaria types are reported as medians (10th and 90th percentiles). **** = p < 0.0001, *** = p < 0.001, ** = p < 0.01, * = p < 0.05

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Malaria Journal

ISSN: 1475-2875

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