Genetic variants of TLR4, including the novel variant, rs5030719, and related genes are associated with susceptibility to clinical malaria in African children

Table 2 Single nucleotide polymorphisms (SNPs) in mothers statistically associated with the incidence of clinical malaria using a Poisson model (q < 0.05)

Gene	rs_value	Reference	Alternate	Minor frequency (mother)	Minor frequency (child)	p-value	Adjusted p-value	q-value	OR
CAT	rs769214	A*	G	0.479094	0.45993	0.0005	0.0005	0.005	1.39 (1.20–1.61)
G6PD	rs1050829	A*	G	0.311224	0.282759	0.004	0.0005	0.029091	1.30 (1.09–1.56)
HP	rs5470	C*	G	0.096939	0.101375	0.0005	0.003	0.005	1.82 (1.39–2.39)
ICAM1	rs5498	A	G*	0.123746	0.115658	0.003	0.0005	0.024	0.705 (0.561–0.884)
IFNGR1	rs2234711	T	C*	0.456376	0.453767	0.0005	0.0005	0.005	0.664 (0.573–0.769)
IFNGR1	rs7749390	A	G*	0.45	0.452862	0.0005	0.0005	0.005	0.661 (0.571–0.765)
IFNG	rs2430561	T	A*	0.201754	0.198606	0.002	0.004	0.017778	0.734 (0.612–0.893)
IL6	rs2069830	C	T*	0.13255	0.142612	0.0005	0.0005	0.005	0.635 (0.531–0.760)
MNSOD	rs4880	T	C*	0.434564	0.423469	0.0005	0.0005	0.005	0.717 (0.619–0.830)
TLR2	rs7656411	G*	T	0.333904	0.333333	0.0005	0.0005	0.005	1.51 (1.29–1.78)
TLR4	rs5030719	G	T*	0.02489	0.024648	0.0005	0.0005	0.005	0.421 (0.301–0.588)

In this table, ‘rs values’ are as defined in the NCBI dbSNP repository, ‘minor frequency’ columns denote the minor allele frequencies of each SNP from the genotypes analysed in this study respectively for mother and child, p-values are the output of Poisson analysis, adjusted p-values are the corresponding p-values re-calculated to consider the children’s SNP as a co-factor, and q-values are the p-values adjusted for multiple testing using a false detection rate (FDR) model. OR denotes the odds ratio of clinical malaria for the minor allele compared to the major allele; the subsequent columns of lower_CI and upper_CI, respectively denote the lower and upper boundaries of the OR 95% confidence interval. In the columns defining the reference and alternate alleles, the genotype conferring risk to malarial incidence is marked with an asterisk (*) as inferred from the OR and its confidence interval

ISSN: 1475-2875