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Table 3 Summary of automated detection of cerebral malaria from retinal imaging

From: Retinal imaging technologies in cerebral malaria: a systematic review

Study Author

Year

Imaging modality

Method

Lesion detected

Sensitivity

Specificity

Accuracy

AUC

DC

Li

2022

FA

Weakly-supervised DL

LFL/PL

0.91 ± 0.02 a

0.97 ± 0.02 a

0.96 ± 0.02 a

0.94 ± 0.02 a

0.85 ± 0.02 a

Kurup

2020

Colour

Transfer DL

Haemorrhage & Whitening

0.90

1

0.81

0.98

–

Chen

2020

Colour

Supervised DL

Haemorrhage

–

–

–

0.94

0.995

Yan

2019

FA

Superpixel-based TCV

LFL / PL

0.95

0.95

–

0.95

–

Zhao

2018

FA

Superpixel-based TCV

LFL / PL

0.95

0.95

–

0.95

–

Rochim

2018

FA

Saliency-based TCV

LFL / PL

-

0.9

0.98

–

–

Joshi

2018

Colour

TCV

Haemorrhage

0.79

0.93

–

0.88

–

Whitening

0.67

0.77

–

0.75

–

MR

0.68

0.92

–

0.82

–

Zhao

2017

FA

Saliency-based TCV

LFL / PL

0.93 ± 0.03

0.96 ± 0.02

0.91 ± 0.03

0.94 ± 0.02

0.82 ± 0.03

Zhao

2017

FA

Saliency-based TCV

LFL / PL

0.83 ± 0.08

0.83 ± 0.03

0.81 ± 0.04

0.83 ± 0.05

–

MacCormick

2017

FA

Spatial statistical model TCV

CNP

–

–

–

–

–

Joshi

2017

Colour

Unsupervised TCV

Haemorrhage

0.73

0.96

–

0.89

–

Whitening

0.65

0.94

–

0.81

–

Vessel Discolouration

0.62

1

–

0.85

–

MR

0.95

1

–

0.97

–

Akram

2017

Colour

TCV

Whitening

0.90

0.92

–

0.9

–

Zhao

2015

FA

Saliency-based TCV

IVFD

0.75

0.74

0.74

0.74

–

Zhao

2015

FA

Saliency-based TCV

LFL

0.95

–

–

–

–

PL

0.82

–

–

–

–

Vessel Leak

0.81

0.82

0.8

0.84

–

Joshi

2015

Colour

TCV

Whitening

0.88 b

0.65 b

–

0.8

–

0.82 c

0.89 c

–

–

–

Ashraf

2015

Colour

TCV

Whitening

–

–

0.92

–

–

Ashraf

2015

Colour

TCV

Haemorrhage

0.95

0.96

0.97

0.95

–

Whitening

–

–

0.92

–

–

CWS

0.82

–

–

–

–

Agurto

2015

Colour

TCV

Vessel Discolouration

0.94 b

0.67 c

0.85

0.87

–

0.68 b

1 c

0.85

–

–

Zheng

2014

FA

Texture-based TCV

CNP

0.73 ± 0.14

0.91 ± 0.06

0.89 ± 0.04

–

–

Saleem

2014

Colour

TCV

Haemorrhage

0.95

0.96

0.97

0.95

–

Joshi

2012

Colour

Splat-based TCV

Haemorrhage

0.81

0.97

–

0.91

–

  1. AUC area under the curve, DC dice coefficient, DL deep learning, MR malarial retinopathy, TCV traditional computer vision
  2. aonly LFL included in quantitative analysis
  3. btuned for sensitivity
  4. ctuned for specificity