Table 1 Parasite clearance rate and changepoint estimates from M4, all methods
Method Treatment group | Parameter estimates with 95% CI | ||||
|---|---|---|---|---|---|
CP (95% CI, hours) | Slope before CP (log10[parasites/ml] / hour) | Slope after CP (log10[parasites/ml] / hour) | HRPC before CP (%) | HRPC after CP (%) | |
Segmented mixed model | |||||
150 mg (n = 6) | 33.9 (28.7, 39.1) | 0.003 ( − 0.004, 0.011) | − 0.090 (− 0.103, − 0.076) | − 0.8 (− 2.5, 0.9) | 18.6 (16.0, 21.1) |
400 mg (n = 8) | 57.4 (52.5, 62.4) | − 0.004 (− 0.007, − 0.001) | − 0.080 (− 0.092, − 0.067) | 0.9 (0.2, 1.6) | 16.8 (14.3, 19.1) |
800 mg (n = 8) | 52.8 (47.4, 58.1) | − 0.008 (− 0.011, − 0.005) | − 0.054 (− 0.066, − 0.042) | 1.9 (1.1, 2.6) | 11.7 (9.3, 14.1) |
Grid − Search Segmented mixed model | |||||
150 mg (n = 6) | 35 (NA) | 0.000 (− 0.006, 0.006) | − 0.088 (− 0.099, − 0.076) | − 0.0 (− 1.4, 1.3) | 18.3 (16.1, 20.4) |
400 mg (n = 8) | 54 (NA) | − 0.003 (− 0.006, 0.001) | − 0.072 (− 0.082, − 0.062) | 0.6 (− 0.2, 1.4) | 15.3 (13.3, 17.2) |
800 mg (n = 8) | 52 (NA) | − 0.008 (− 0.012, − 0.005) | − 0.053 (− 0.063, − 0.043) | 1.9 (1.1, 2.6) | 11.5 (9.5, 13.6) |
Two-stage segmented regression approach | |||||
150 mg (n = 6) | 36.1 (29.9, 42.2) | 0.000 (− 0.006, 0.006) | − 0.093 (− 0.107, − 0.078) | 0.1 (− 1.3, 1.4) | 19.2 (16.4, 21.9) |
400 mg (n = 8) | 58.9 (53.2, 64.6) | − 0.004 (− 0.007, − 0.001) | − 0.081 (− 0.094, − 0.068) | 0.9 (0.3, 1.6) | 17.0 (14.4, 19.5) |
800 mg (n = 8) | 51.8 (45.8, 57.7) | − 0.008 (− 0.011, − 0.005) | − 0.052 (− 0.065, − 0.039) | 1.8 (1.2, 2.4) | 11.3 (8.7, 13.8) |