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Table 3 PCR uncorrected treatment outcome

From: Therapeutic efficacy of artesunate–amodiaquine and artemether–lumefantrine for the treatment of uncomplicated falciparum malaria in Chad: clinical and genetic surveillance

Treatment outcome

Artemether–lumefantrine

Artesunate–amodiaquine

Doba (n = 31)

Kelo (n = 48)

Kayom (n = 35)

Doba (n = 33)

Kelo (n = 33)

Kayom (n = 35)

n (%)

CI 95%

n (%)

95% CI

n (%)

95% CI

n (%)

CI 95%

n (%)

95% CI

n (%)

95% CI

Per-protocol

ETF

0 (0)

0.0–12.3

0 (0)

0.0–7.4

0 (0)

0.0–10.0

0 (0)

0.0–11.6

0 (0)

0.0–11.2

0 (0)

0.0–10.6

LCF

0 (0)

0.0–12.3

0 (0)

0.0–7.4

0 (0)

0.0–10.0

0 (0)

0.0–11.6

0 (0)

0.0–11.2

0 (0)

0.0–10.6

LPF

0 (0)

0.0–12.3

4 (8.3)

2.3–20.0

1 (2.9)

0.1–14.9

1 (3.3)

0.1–17.2

0 (0)

0.0–11.2

0 (0)

0.0–10.6

ACPR

28 (100)

87.7–100

44 (91.7)

80.0–97.7

34 (97.1)

85.1–99.9

29 (96.7)

82.8–99.9

31 (100)

88.8–100

33 (100)

89.4–100

Total per-protocol

28

 

48

 

35

 

30

 

31

 

33

 

Withdrawn/lost

3 (9.7)

 

0 (0)

 

0 (0)

 

3 (9.1)

 

2 (6.1)

 

2 (5.7)

 

Kaplan–Meier

Cure rate

100

NA

91.7

79.3–96.8

97.1

 

96.7

80.4–99.6

100

NA

100

NA

  1. ETF early treatment failure, LCF late clinical failure, LPF late parasitological, ACPR adequate clinical and parasitological response