Table 2 ROC curve analysis of pro-and anti-inflammatory cytokines
Cytokines | Cut-off value (pg/ml) | AUC value (%) | P value | Sensitivity (%) | Specificity (%) | Likelihood ratio | |
|---|---|---|---|---|---|---|---|
IL-1β | > 32.63 | 72.7 | 0.0476 | 75 | 66.67 | 2.25 | |
IL-6 | > 795.4 | 54.2 | 0.6976 | 57.7 | 70 | 1.923 | |
IL-2 | > 110.4 | 53.2 | 0.7772 | 45.83 | 66.67 | 1.375 | |
IL-12 | > 100.2 | 59.7 | 0.3960 | 70.83 | 55.56 | 1.594 | |
IL-17A | > 85.34 | 82.4 | 0.0047 | 66.67 | 88.89 | 6.000 | |
GM-CSF | < 18.35 | 51.9 | 0.8598 | 73.08 | 50 | 0.462 | |
IL-4 | > 128.6 | 54.2 | 0.7160 | 25 | 88.89 | 2.250 | |
IL-10 | > 5880 | 57.2 | 0.5310 | 29.17 | 77.78 | 1.313 | |
Cytokines | Cut-off value (MFI) | AUC value (%) | P value | Sensitivity (%) | Specificity (%) | Likelihood ratio |
|---|---|---|---|---|---|---|
Eotaxin | > 15 | 56.7 | 0.5578 | 58.33 | 77.78 | 2.625 |
IFN-γ | > 12.50 | 68.1 | 0.1149 | 75 | 66.67 | 2.250 |
RANTES | > 169.5 | 51.9 | 0.8715 | 95.83 | 0 | 0.9583 |
IL-7 | > 9.500 | 59.8 | 0.3593 | 72.41 | 40 | 1.207 |
MIP-1β | > 29.00 | 52.5 | 0.8265 | 85.19 | 22.22 | 1.095 |
MIP-1α | > 9.500 | 55.1 | 0.6479 | 77.8 | 44.44 | 1.4 |
MIG | > 26.50 | 71.8 | 0.0528 | 88.89 | 71.94 | 1 |
TNF | < 9.000 | 53.3 | 0.7701 | 37.04 | 55.56 | 0.8333 |
IP-10 | > 229.0 | 51.0 | 0.5451 | 88.89 | 11.11 | 1 |
IL-2R | > 19.00 | 70.2 | 0.0734 | 96.3 | 33.33 | 1.444 |
IL-8 | > 31.00 | 57.4 | 0.4892 | 89.66 | 10 | 0.9962 |
IL-5 | < 5.000 | 66.7 | 0.1432 | 4 | 88.89 | 0.36 |
IL-15 | > 14.50 | 53.3 | 0.6395 | 96 | 0 | 0.96 |
MCP-1 | < 8.500 | 55.6 | 0.6256 | 4 | 100 | NA |
IL-13 | < 4.500 | 56.4 | 0.5714 | 40 | 77.78 | 1.800 |
IL-1RA | > 85.50 | 56.9 | 0.5451 | 92 | 22.22 | 1.183 |
IFN-α | < 8.500 | 55.6 | 0.6237 | 46.15 | 77.78 | 2.077 |