Evolution of genetic markers for drug resistance after the introduction of dihydroartemisinin–piperaquine as first-line anti-malarial treatment for uncomplicated falciparum malaria in Indonesia

Table 3 Genotyping results of the parasites at day 0 and day of recurrence in P. falciparum Papua TES

Isolate code	D0 strain MSP1^a/MSP2^b/GLURP^c	DR strain MSP1^a/MSP2/^bGLURP^c	Day of recurrence	Recurrent/reinfection
PAF 204	K1/FC27/Code1	K1/FC27/Code1	D42	Recrudescent
PAF 205	K1/FC27/Code2	K1-RO33/FC27/Code3	D42	Reinfection
PAF 213	K1/FC27/Code1	K1/3D7/Code1	D42	Reinfection
PAF 221	K1/FC27/Code2	K1-RO33/FC27/Code3	D28	Reinfection
PAF 222	K1/FC27/Code3	MAD20/3D7/Code3	D42	Reinfection
PAF 266	K1/FC27/Code1	K1/3D7/Code1	D28	Reinfection
PAF 274	K1/MAD20/FC27Code2	RO33/3D7/Code3	D28	Reinfection
PAF 307	K1/FC27/Code3	MAD20/3D7/Code3	D35	Reinfection
PAF 335	K1/FC27/Code1	K1/3D7/Code1	D28	Reinfection
PAF 358	K1/MAD20/FC27Code2	RO33/3D7/Code3	D42	Reinfection

^aMSP1 amplicon: K1 = 150–300 base pairs (bp); MAD20 = 150–400 bp; and RO33 = 120–230 bp
^bMSP2 amplicon: FC27 = 250–700 bp; 3D7 = 280–780 bp
^cGLURP amplicon: Code1 = 501–600 bp; Code2 = 601–700 bp; and Code3 = 701–800 bp

ISSN: 1475-2875