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Table 1 Expert perspectives on the implementation barriers for introducing TACTs in Southeast Asia (derived from de Haan et al. [14])

From: Strategies for deploying triple artemisinin-based combination therapy in the Greater Mekong Subregion

Implementation barrier

Explanation

Intensified prescriber training

Intensifying training requirements for correct TACT prescription

Donor funder support

Obtaining support by donor funders to cover TACT implementation costs and potential price increases

National policy support

Obtaining support from national malaria control programs and other national decision makers to engage in the deployment of TACT

WHO and global policy support

Obtaining support from the WHO and other global decision makers to engage in the deployment of TACT

Availability of fixed-dose combination (FDC) TACT

Ensuring timely development and production of fixed-dose combination (FDC) for TACT

Community acceptance

Ensuring community acceptance by providing clear communication and tackling potential misconceptions about TACT

Collecting safety and efficacy data

Collecting sufficient efficacy and safety data to support the introduction of TACT

Supply chain logistics

Adapting import, procurement and supply routes for the introduction of TACT

Regulatory approval

Obtaining timely regulatory approval for introducing TACT in Southeast Asia

Set up surveillance systems

Setting up surveillance systems to monitor drug resistance rates and adherence to TACT

Private sector engagement

Engaging the (informal) private sector in TACT deployment and creating demand beyond official programs

Set up pharmacovigilance systems

Setting up a pharmacovigilance system for TACT

Stockpile management

Managing stockpiles for countries that still have ACT stocks or contract deals with ACT producers