Table 2 Examples of experimental types which could be applied as validation sub-studies for methods used to evaluate vector control products
Method purpose | Example/outcome | Sub-studies | Analytical parameters |
|---|---|---|---|
Measure immediate lethality effects | • KD and 24 h mortality | • Define test conditions (P) • Replication • Comparison* | • Robustness (P) • Precision |
Quantify downstream outcomes | • Delayed mortality (72–96 h) • Impacts on fecundity | • Define test conditions (P) • Replication • Comparison* | • Robustness (P) • Precision |
Monitor success/failure of an outcome during exposure | • Blood-feeding success | • Define test conditions (P) • Replication • Comparison* | • Robustness (P) • Precision |
Measure induced sterility | • Oviposition inhibition | • Define test conditions (P) • Replication • Comparison* | • Robustness (P) • Precision |
Characterize behavioural responses during- and post-exposure | • Proportion of net contact time | • Define test conditions (P) • Replication • Comparison* | • Robustness (P) • Precision |
Monitor durability | • Efficacy of ITNs after 3 years deployment • Duration of IRS efficacy | • Define test conditions (P) • Linearity and reportable range • Comparison* | • Robustness (P) • Linearity • Range • Precision |
Evaluate combination products | • ITN with different concentration/s of AI/s on different parts of the net | • As per method purpose for each combination | • As per method purpose for each combination |