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Table 2 Malaria infection prevalence in children 6 months to 14 years of age in the 3rd year follow up at 28 and 33 months post intervention

From: Effectiveness of piperonyl butoxide and pyrethroid-treated long-lasting insecticidal nets (LLINs) versus pyrethroid-only LLINs with and without indoor residual spray against malaria infection: third year results of a cluster, randomised controlled, two-by-two factorial design trial in Tanzania

Intervention

Intention to treat

Per protocola

n/N

%

OR

95%CI

P-value

n/N

%

OR

95%CI

P-value

Survey 28 months

          

 Standard LLINb

1643/2032

80.9

1

  

762/962

79.2

1

  

 PBO-Pyrethroid LLINc

1280/1848

69.3

0.45

0.21–0.95

0.0364

507/755

67.2

0.43

0.22–0.84

0.0151

 No IRSd

1441/1897

76.0

1

  

663/881

75.3

1

  

 IRSe

1482/1983

74.7

0.79

0.44–1.41

0.4172

606/836

72.5

0.71

0.39–1.30

0.2615

 Interaction coefficient

  

1.38

0.53–3.69

0.505

  

1.59

0.62–4.07

0.3239

Survey 33 months

          

 Standard LLINb

1045/1784

58.6

1

  

291/509

57.2

1

  

 PBO-Pyrethroid LLINc

901/1807

49.9

0.60

0.32–1.13

0.1131

200/453

44.2

0.34

0.16–0.71

0.0051

 No IRSd

1009/1776

56.8

1

  

257/500

51.4

1

  

 IRSe

937/1815

51.6

0.52

0.25–1.07

0.0747

234/462

50.7

0.57

0.31–1.06

0.0736

 Interaction coefficient

  

1.78

0.71–4.49

0.2131

  

3.11

1.18–8.20

0.0230

  1. OR odds ratio for the factorial analysis compared the two-main intervention effect 1/ PBO-pyrethroid LLIN vs standard LLIN and 2/IRS vs no IRS and their interaction. OR unadjusted for baseline plasmodium infection prevalence
  2. aPer protocol includes only children sleeping under the allocated nets
  3. bStandard LLIN and standard LLIN & IRS groups
  4. cPBO-Pyrethroid LLIN and PBO-Pyrethroid LLIN & IRS groups
  5. dStandard LLIN and PBO-Pyrethroid LLIN groups
  6. estandard LLIN & IRS and PBO-Pyrethroid LLIN & IRS groups
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Malaria Journal

ISSN: 1475-2875

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