Table 5 Comparison of microscopy, RDT, uRDT for detecting P. falciparum in Primi, Secundi and multigravidae at baseline
| Â | Â | Â | qPCR | Value (95%CI) | LR (+) (95%CI) | LR (-) (95%CI) | Kappa (95%CI) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Sensitivity (95%CI) | Specificity (95%CI) | PPV (95%CI) | NPV (95%CI) | ||||||||
Primigravidae (N = 94) | Test |  | (+) | (-) |  |  |  |  |  |  |  |
Microscopy | (+) | 39 | 2 | 67.2% (53.6–78.9) | 94.4% (81.3–99.3) | 95.1 (83.3–98.7) | 64.1 (55.1–72.2) | 12.1 (3.1–47.1) | 0.3 (0.2–0.5) | 0.57 (0.41–0.71) | |
(-) | 19 | 34 | |||||||||
RDT | (+) | 53 | 3 | 91.3% (81–97.1) | 91.7% (77.5–98.2) | 94.6% ( 85.6–98.1) | 86.8% (74–93.9) | 11.0 (3.7–32.5) | 0.09 (0.0–0.2) | 0.82 (0.7–0.93) | |
(-) | 5 | 33 | |||||||||
uRDT | (+) | 56 | 4 | 96.6% (88–99.6) | 88.9% (73.9–96.9) | 93.3% (84.7–97.3) | 94.1 (80.3–98.4) | 8.7 (3.4–21.9) | 0.0 (0.0–0.1) | 0.86 (0.76–0.96) | |
(-) | 2 | 32 | |||||||||
Secundigravidae (N = 52) | Microscopy | (+) | 17 | 0 | 63% (42.3–80.6) | 100% (86.2–100) | 100% | 71.4% (60.4–80.4) | - | 0.37 (0.2–0.6) | 0.62 (0.42–0.81) |
(-) | 10 | 25 | |||||||||
RDT | (+) | 22 | 1 | 81.5% (61.9–93.7) | 96% (79.7–99.9) | 95.7% (76.1–99.3) | 82.8 (68.4–91.4) | 20.4 (3.0–140.2) | 0.2 (0.1–0.4) | 0.77 (0.6–0.94) | |
(-) | 5 | 24 | |||||||||
uRDT | (+) | 26 | 1 | 96.3% (81–99.9) | 96% (79.7–99.9) | 96.3% (79.1–99.4) | 96.6% (77.8–99.4) | 24.1 (3.5–164.5) | 0.0 (0.0–0.3) | 0.92 (0.81–1) | |
(-) | 1 | 24 | |||||||||
Multigravidae (N = 103) | Microscopy | (+) | 24 | 2 | 53.3% (36.9–68.3) | 96.6% (88.0 – 99.6) | 92.3% (75–98) | 72.7% (66–78.5) | 15.5 (3.9–62.0) | 0.5 (0.3–0.7) | 0.52 (0.4–0.7) |
(-) | 21 | 56 | |||||||||
RDT | (+) | 31 | 2 | 68.8% (53.3–81.8) | 96.6% (88.0–99.6) | 93.9% (79.7–98.4) | 80% (72.0–86.1) | 20.0 (5.0–79.0) | 0.3 (0.2–0.5) | 0.67 (0.53–0.81) | |
(-) | 14 | 56 | |||||||||
uRDT | (+) | 34 | 2 | 75.6 (60.5–87.1) | 96.5% (88.0–99.6) | 94.4% (81.2–98.5) | 83.5% (75.2–89.5) | 22.0 (5.6–86.4) | 0.2 (0.1–0.4) | 0.73 (0.6–0.87) | |
(-) | 11 | 56 | |||||||||