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Table 6 Comparison of microscopy, uRDT, and RDT sensitivity stratified by parasite density (p/μL) as determined by qPCR

From: Performance of ultra-sensitive malaria rapid diagnostic test to detect Plasmodium falciparum infection in pregnant women in Kinshasa, the Democratic Republic of the Congo

Parasite density

qPCR (+)

Microscopy (+)

Microscopy sensitivity (95% CI)

RDT(+)

RDT sensitivity (95% CI)

uRDT (+)

uRDT Sensitivity (95% CI)

 < 100

50

10

20% (10.0–33.7)

31

62% (47.1–75.3)

34

68% (53.3–80.4)

100–200

19

9

47.3% (24.4–71.1)

17

89.4% (66.8–98.7)

19

100% (82.3–100)

 > 200

89

69

77.5% (67.4–85.7)

81

91% (83.0–96.0)

86

96.6% (90.0–99.3)

  1. RDT (rapid diagnostic test); uRDT (ultra-sensitive rapid diagnostic test); qPCR (quantitative polymerase chain reaction); (+) (positive); (-) (negative); PPV (positive predictive value); NPV (negative predictive value); CI (confidence interval); N (sample size)