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Fig. 8 | Malaria Journal

Fig. 8

From: Human monoclonal antibodies inhibit invasion of transgenic Plasmodium knowlesi expressing Plasmodium vivax Duffy binding protein

Fig. 8

Binding organization of the DBP-DARC heterotetramer: A Uncoupled DBP monomers on apical membrane of P. vivax and the DARC dimer on the surface of the erythrocyte membrane. B–D Multi-step binding sequence of DBP to DARC – initial binding of DBP monomer to the DARC dimer (1), dimerization of DBP monomers (2), and secondary binding of DBP dimer to DARC dimer. E Interference of heterotetramer formation by SD2-binding (orange) and SD3-binding (green) humAbs

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Malaria Journal

ISSN: 1475-2875

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