Molecular surveillance of chloroquine resistance in Plasmodium vivax isolates from malaria cases in Yunnan Province of China using pvcrt-o gene polymorphisms

Table 3 SNPs of the full-length CDS of pvcrt-o gene in P. vivax strains from vivax malaria cases

OD	Loci	AL	Coding	AAV	TMD	Frequency
OD	Loci	AL	Coding	AAV	TMD	No. of all CDSs (n = 272) No. (F, %)	2020 (n = 102) No. (F, %)	2021 (n = 92) No. (F, %)	2022 (n = 78) No. (F, %)
1	c.7	A>G	ATC/GTC	I3V	Outside	12 (4.4)	10 (3.7)	1 (0.4)	1 (0.4)
2	c.37	C>T	CCC/TCC	P13S	Outside	2 (0.7)	0	1 (0.4)	1 (0.4)
3	c.772	T>A	TGC/AGC	C258S	7	3 (1.1)	1 (0.4)	2 (0.7)	0
4	c.936	C>T	TGC/TGT	C312C	Inside	2 (0.7)	1 (0.4)	1 (0.4)	0
5	c.987	C>T	GAC/GAT	D329D	8	3 (1.1)	1 (0.4)	0	2 (0.7)
6	c.1032	C>G	ACC/ACG	T344T	9	4 (1.5)	3 (1.1)	1 (0.4)	0
7	c.1164	C>T	TCC/TCT	S388S	10	27 (9.9)	17 (6.3)	3 (1.1)	7 (2.6)

OD, AL, AAV, TMD, F are order, alleles, amino acid variation, transmembrane domain (inside and outside mean the inside and outside the digestive vesicle and frequency; the different Arabic numerals mean some transmembrane region), respectively
bolditalic values used to indicate that the mutant type base of the triplet code on the right where it is replaced from the original type on the left

ISSN: 1475-2875