Fig. 5

Immunological pathways associated with P. knowlesi infection in pig-tailed macaques. A Bubble plot of blood transcription modules identified by Gene Set Enrichment Analysis (GSEA). Upregulated modules shown in red and downregulated modules in blue. GSEA based on an FDR of 0.05. NES, normalized enrichment score. B Heatmap of genes in the inflammatory/TLR/chemokine blood transcription module that have at least one gene comparison timepoint below an FDR of 0.1. Upregulated genes in red and downregulated genes in blue. All pairwise contrasts for the first infection performed versus the first baseline, and all pairwise contrasts for the second infection performed versus the second baseline