Fig. 5

Selection signatures observed in each selected line. SNPs diverging between the control line and each selected line were identified using a frequency-based approach (Diff SNPs) and a FST-based approach (outlier SNPs) and then averaged by gene (see methods). The upper Y axis shows the mean Diff SNP score per gene. The lower Y axis shows the proportion of outliers per gene. Symbol size increases with the number of polymorphic SNPs per gene. Triangles and circles denote candidate and non-candidate genes, respectively. Filled symbols indicate the presence of at least one differential or outlier SNP affecting the protein sequence. Blue and red symbols indicate candidate genes with a mean differential score > 0.4 or > 20% outliers, respectively; the corresponding gene names are indicated. Loci commonly associated with insecticide resistance in An. gambiae are indicated by dashed lines. The genomic scale shows chromosome arms with ticks every 10 Mb