Malaria elimination in Ghana: recommendations for reactive case detection strategy implementation in a low endemic area of Asutsuare, Ghana

Table 5 Clinical performance of rt-PCR and RDT in the diagnosis of malaria using microscopy as the gold standard

Clinical Performance Indicators		Diagnostic techniques
Clinical Performance Indicators		rt-PCR	RDT
Sensitivity	%	33.33	76.54
Sensitivity	CI₉₅	4.33–77.72	66.82–85.54
Specificity	%	92.55	97.30
Specificity	CI₉₅	85.26–96.95	93.87–99.13
Positive Predictive Value	%	30.69	92.53
Positive Predictive Value	CI₉₅	10.41–62.77	83.80–96.74
Negative Predictive Value	%	93.35	90.56
Negative Predictive Value	CI₉₅	88.83–96.12	86.61–93.43
Accuracy	%	87.22	91.05
Accuracy	CI₉₅	79.06–93.06	86.97–94.18
ROC Analysis	AUC	0.67	0.57
	CI₉₅	0.36–0.89	0.31–0.83
	Standard error	0.13	0.029
	p-value	0.344	0.589
Cohen’s Kappa	Κ	0.21	0.19
	Standard error	0.16	0.18
	p-value	0.032	0.054

CI₉₅, 95% Confidence Interval; ROC, Receiver Operator Characteristics; AUC , Area Under Curve

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