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Fig. 5 | Malaria Journal

Fig. 5

From: Evaluation of a new fusion antigen, cd loop and HAP2-GCS1 domain (cd-HAP) of Plasmodium falciparum Generative Cell Specific 1 antigen formulated with various adjuvants, as a transmission blocking vaccine

Fig. 5

Endpoint titration of anti-cd-HAP IgG, IgG1, IgG2a, and IgG2b antibodies in different vaccine groups. Mouse sera from groups 1–5 were analysed by ELISA with dilutions ranging from 1:200 to 1:409,600. The titers were determined as the last dilution with an OD450 nm above the corresponding cut-off value for each antibody subclass: IgG (0.26), IgG1 (0.2), IgG2a (0.16), and IgG2b (0.15). The cut-off values are indicated with a horizontal line. The highest endpoint titers of anti-cd-HAP total IgG, IgG2a, and IgG2b were observed in group 5 (cd-HAP/CMQ), while the lowest endpoint titers for IgG were detected in groups 1 (cd-HAP alone) and 3 (cd-HAP/MPL)

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Malaria Journal

ISSN: 1475-2875

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