Table 2 Target infection rates and inputs used to generate them in Simulation Study 2

Infection rates observed in each trial

Proportion of controls infected during follow-up

0.39

0.71

0.56

Proportion of subjects in treatment arm infected during follow-up

0.26

0.28

0.36

Inputs to simulation study

Exposure rate

1/741

1/182

1/204

Clone blocking probability

0.61

0.80

0.76

Mean number of clones at first infection in control group

2.26

1.46

3.00

Follow-up duration

12 months (364 days)

8 months (224 days)

6 months (168 days)