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Table 3 Bivariate analysis of factors influencing patients’ adherence to ACT treatment in Kamuli District

From: Factors influencing patients’ adherence to malaria artemisinin-based combination therapy in Kamuli District, Uganda

Variable

Adhered

Did not adhere

Test-statistic

p-value

95% CI (lower, upper)

Socio-demographic factors

 Age

Mean Diff = 2.993

2.258

0.024*

(0.391, 5.594)

 Gender

  Male

207 (66.8)

94 (31.2)

0.178

0.673

 

  Female

381 (70.2)

162 (29.8)

 Marital status

  In relationship

370 (71.6)

147 (28.4)

2.276

0.131

 

  Not in a relationship

218 (66.7)

109(33.)

 Household size

Mean Diff = − 0.287

− 1.442

0.150

(− 0.677, 0.104)

 Household head

  Father

451 (67.7)

215 (32.3)

14.484

0.002*

 

  Mother

79 (79)

21 (21)

  Sibling

9 (47.4)

10 (52.6)

  Grandparent

48 (82.8)

10 (17.2)

 Relationship to household head

  Son

119 (71.7)

47 (28.3)

10.95

0.09**

 

  Daughter

178 (68.2)

83 (31.8)

  Sibling

8 (47.1)

9 (52.9)

  Grandchild

30 (76.9)

9 (23.1)

  Grand parent

3 (75)

1 (25)

  Self

107 (77)

32 (23)

  Partner

143 (65.6)

75 (34.4)

Socio-economic factors

 Education level

  Primary

230 (73.2)

84 (26.8)

7.427

0.191

 

  Below certificate

174 (66.7)

87 (33.3)

  Certificate holder

123 (65.4)

65 (34.6)

  Diploma holder

13 (68.4)

6 (31.6)

  Masters/PGD/PhD

4 (100)

0 (0)

  No formal education

44 (75.9)

14 (24.1)

 Employment status

  Formal employment

52 (71.2)

21 (28.8)

35.886

0.000*

 

  Informal employment

217 (59.1)

150 (40.9)

  Not employed at all

319 (79)

85 (21)

 Monthly income

Mean Diff = − 25.686

− 0.001

0.999

(− 40433.157, 40381.786)

 Has transport means to facility

  Yes

425 (68.7)

194 (31.3)

1.043

0.307

 

  No

162 (72.3)

62 (27.7)

 Source of information in homestead

  Radio

335 (66.3)

170 (33.7)

6.866

0.076**

 

  Television

75 (76.5)

23 (23.5)

  Both radio and television

91 (73.4)

33 (26.6)

  No

87 (74.4)

30 (25.6)

 Nature of family house

  Rented

135 (74.6)

46 (25.4)

5.671

0.129

 

  Owned—permanent

266 (65.8)

138 (34.2)

  Owned—semi permanent

157 (72.4)

60 (27.6)

  Owned—temporary

30 (71.4)

12 (28.6)

Socio-cultural factors

 Religion

  Ccatholic

130 (73.9)

46 (26.1)

4.723

0.451

 

  Anglican

267 (69.7)

116 (30.3)

  Muslim

82 (67.2)

40 (32.8)

  Born again Christian

105 (68.2)

49 (31.8)

  Traditional believer

1 (50)

1 (50)

  Seventh Day Adventist

3 (42.9)

4 (57.1)

 Prefer ACT to other antimalarials

  Yes

477 (73)

176 (27)

15.981

< 0.0001*

 

  No

110 (57.9)

80 (42.1)

 Perceived preference of drug formulation

  Tablet

488 (70.8)

201 (29.2)

5.875

0.053**

 

  Syrup

18 (52.9)

16 (47.1)

  Injection

51 (64.6)

28 (35.4)

 Satisfied with waiting time to get service

  Yes

370 (71.3)

149 (28.7)

1.63

0.213

 

  No

210 (67.1)

103 (32.9)

 Took herbal medicine with ACT

  Yes

143 (67.5)

69 (32.5)

0.803

0.387

 

  No

442 (70.7)

183 (29.3)

Health system factors

 Patient/caregiver given instructions on how to take the medicine

  Yes

542 (71.1)

220 (28.9)

7.134

0.011*

 

  No

46 (56.8)

35 (43.2)

 Patient took first dose of ACT at the facility under observation of health worker

  Yes

75 (68.8)

34 (31.2)

0.044

0.824

 

  No

513 (69.8)

222 (30.2)

 A qualified health worker saw patient

  Yes

524 (70)

225 (30)

0.085

0.81

 

  No

63 (68.5)

29 (31.5)

 ACT package used as visual aid for instructions

  Yes

323 (67.9)

153 (32.1)

1.960

0.173

 

  No

264 (72.3)

101 (27.7)

 Know right dosage of ACT

  Yes

508 (70.4)

214 (29.6)

1.260

0.286

 

  No

79 (65.3)

42 (34.7)

 Satisfied with getting ACT medicine at facility

  Yes

515 (74.9)

173 (25.1)

48.261

< 0.0001*

 

  No

72 (46.5)

83 (53.5)

 Patient present with fever

  Yes

569 (69.7)

247 (30.3)

0.045

0.836

 

  No

19 (67.9)

9 (32.1)

 Malaria diagnostic method

  Microscopy

308 (70)

132 (30)

1.122

0.571

 

  RDT

277 (69.6)

121 (47.3)

  Both

3 (50)

3 (50)

 Patients know the ACT prescribed

  Yes

465 (67.9)

220 (32.1)

5.483

0.019*

 

  No

123 (77.4)

36 (22.6)

 Participant ever saved ACT medicines (history of saving ACT)

  Yes

77 (51.7)

72 (48.3)

39.242

< 0.0001*

 

  No

178 (25.7)

515 (74.3)

 Participant ever shared ACT medicines

  Yes

67 (50.8)

65 (49.2)

30.893

< 0.0001*

 

  No

189 (26.5)

523 (73.5)

  1. ACT artemisinin-based combination therapy, RDT malaria rapid diagnostic test, Mean Diff mean difference, CI confidence interval
  2. *Statistically significant
  3. **Borderline statistical significance