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Fig. 1 | Malaria Journal

Fig. 1

From: Superior protection in a relapsing Plasmodium cynomolgi rhesus macaque model by a chemoprophylaxis with sporozoite immunization regimen with atovaquone-proguanil followed by primaquine

Fig. 1

The study design flowchart depicts the randomization of 18 healthy rhesus monkeys into three groups. Group 1 (n = 6) and group 2 (n = 6) animals received three CPS immunizations with 25–35 bites of P. cynomolgi-infected mosquitoes under two different drug regimens. Control animals in group 3 (n = 6) received 25–35 bites from uninfected mosquitoes under either the same drug regimen as animals in group 1 (A; n = 3) or as group 2 (B; n = 3). After the final immunization, all animals were challenged with an IV injection of 104 P. cynomolgi sporozoites on day 112 and then monitored for primary infection and subsequent relapses

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Malaria Journal

ISSN: 1475-2875

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