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Fig. 2 | Malaria Journal

Fig. 2

From: Superior protection in a relapsing Plasmodium cynomolgi rhesus macaque model by a chemoprophylaxis with sporozoite immunization regimen with atovaquone-proguanil followed by primaquine

Fig. 2

Determination of an appropriate challenge dose of P. cynomolgi sporozoites. Animals were IV challenged with varying doses of sporozoites (106, 105, 104, and 103) in PBS containing 5% BSA. The time taken for primary infection and the interval between primary infection and relapses were recorded. A dose of 106 sporozoites was used as a positive control for comparison. Parasitaemia was determined using both thick blood smears (low parasitaemia) and thin blood smears (high parasitaemia). Each parasitaemia episode was treated with CQ and for the last relapse with both CQ and PQ (A). A challenge dose of 104 sporozoites was chosen based on the results of the first experiment and was then retested in a second experiment (B)

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Malaria Journal

ISSN: 1475-2875

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