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Volume 11 Supplement 1

Challenges in malaria research

Do topical repellents divert mosquitoes within a community?

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Background

Repellents are compounds which interfere with the mosquito’s olfactory system hindering them to identify their hosts and succeeding in taking a blood-meal [1]. However, repellents do not eliminate the host-seeking mosquitoes, they simply reduce human-vector contact. Consequently, there is a possibility that individuals, who do not use repellents, experience more bites than usual because mosquitoes are diverted from the repellent users. The objective of this study was to measure if diversion occurs from households that use repellents to those that don’t within a community with incomplete topical repellent coverage.

Materials and methods

An interventional study was performed in three villages of southern Tanzania using 15%-DEET (N,N-Diethyl-meta-toluamide) and a placebo lotion. Three coverage scenarios were investigated: complete repellent coverage (all households were given 15%-DEET), incomplete repellent coverage (80% of households were given DEET-15% and 20% were given a placebo lotion) and no repellent coverage (all households were given a placebo lotion). The coverage scenarios were rotated between villages. Mosquito densities were measured through aspiration of indoor and outdoor resting mosquitoes respective to each enrolled household. Data was analysed using mixed-effects models and the no coverage scenario was used as reference.

Results

Placebo users living in a village where 80% of the households used 15%-DEET were likely to have nearly three times more mosquitoes (p<0.001) resting in their dwellings in comparison to households in a village where nobody uses repellent (Table 1).

Table 1 Incidence rate ratios (IRR), model estimated means1, confidence intervals and p-values of mean number of mosquitoes aspirated per night per household by treatment group

Conclusions

There is strong evidence that mosquitoes are diverted between households that use repellent to those that don’t. This study arises questions on health equity associated with repellent usage. Policy makers should take into consideration these results while devising vector control programs, as less privileged individuals are likely to suffer more mosquito bites and therewith be more exposed to vector-borne diseases if universal coverage is not reached.

References

  1. 1.

    Davis EE: Insect repellents: concepts of their mode of action relative to potential sensory mechanisms in mosquitoes (Diptera: Culicidae). J Med Entomol. 1985, 22: 237-243.

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Acknowledgments

We would like to thank the people of Sanje, Upper and Lower Matete for their support during the project.

Author information

Correspondence to Marta Maia.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Placebo
  • Control Program
  • Vector Control
  • Universal Coverage
  • Interventional Study

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