From: Malaria in South America: a drug discovery perspective
Compound | Authors | Plant with the lowest IC50 | Type | IC50(P. falciparum strain) |
---|---|---|---|---|
1 | Bravo et al.[34] | Bowdichia virgiloides | Extracts | 1.0 μg/mL |
Isolated substances | 5 μg/mL (F32 and Indo) | |||
- | Deharo et al.[35] | Bowdichia virgiloides | Extracts | 1 μg/mL (F32) |
2 | da Silva Filho et al.[36] | Baccharis dracunculifolia | Extracts | 13 μg/mL |
Isolated substances | 0.8 μg/mL (W2 e D6) | |||
3 | de Andrade-Neto et al.[37] | Picrolemma spruce | Isolated substances | 0.002 μM (K1) |
4 | de Andrade-Neto et al.[38] | Holostylis reniformis | Isolated substances | 0.20 μM (field isolate) |
- | Kayano et al.[39] | Caesalpina pluviosa | Extracts | 0.59 μg/mL (3D7) |
5 | Rocha e Silva et al.[40] | Piper peltatum | Isolated substances | 0.05–2.11 μg/mL (M1) |
5 | Pinto et al.[41] | Pothomorphe peltata | Isolated substances | 0.67 μM (K1) |
- | Garavito et al.[42] | Remijia peruviana | Extracts | 0.85 μg/mL (FcB2) |
- | Debenedetti et al.[43] | Buddleja globosa | Extracts | 8.9 μg/mL (K1) |
- | Baelmans et al.[44] | Caesalpina pluviosa | Extracts | 8 μg/mL (D2) |
- | Flores et al.[45] | Caesalpina pluviosa | Extracts | 3.4 μg/mL |
Isolated substances | Inactive (F32) | |||
- | Ibáñez-Calero et al.[46] | Rumex obtusifolius | Isolated substances | 71 μg/mL i |
- | Muñoz et al.[47] | Sparanttanthelium amazonum | Extracts | 2 μg/mL (F32) |
- | Muñoz et al.[48] | Swietenia macrophylla | Extracts | 73% ii |
- | Muñoz et al.[49] | Tripodanthus acutifolis | Extracts | 98% iii |
- | Costa et al.[50] | Montrichardia linifera | Extracts | 11.7 μg/mL (W2) |
- | da Silva Filho et al.[51] | Nectandra megapotamica | Extracts | 28 μg/mL |
Isolated substances | 3.8 μg/mL (D6) | |||
- | de Andrade-Neto et al.[52] | Bidens pilosa | Extracts | 3.1 μg/mL (D6) |
- | de Andrade-Neto et al.[53] | Remijia ferruginea | Extracts | 48% iv |
- | de Mesquita et al.[54] | Matayba guianensis | Isolated substances | 2.5 μg/mL (FcB1) |
- | Dolabela et al.[55] | Esenbeckia febrifuga | Extracts | 15.5 μg/mL |
Isolated substances | 75.3 μg/mL (W2) | |||
- | Estevam et al.[56] | Ouratea nitida | Extracts | 51.04% v |
- | Fischer et al.[57] | Xylopia emarginata | Extracts | 3.3 μg/mL (PA) |
- | Morais et al.[58] | Pentacalia desiderabilis | Isolated substances | 7.82 μg/mL (K1) |
- | Oliveira et al.[59] | Bidens pilosa | Extracts | 38% vi |
- | Sá et al.[60] | Physalis angulata | Isolated substances | 2.2 μM (W2) |
- | Uchôa et al.[61] | Cecropia pachystachya | Extracts | 66% 4 |
Isolated substances | 58% vii | |||
- | Loyola et al.[62] | Azorella compacta | Isolated substances | 60% viii |
- | Pabón et al.[63] | Solanum nudum | Isolated substances | 21 μM (FcB2) |
- | Céline et al.[64] | Siparuna aspera | Extracts | 6.4 μg/mL (FCR-3) |
- | Ruiz et al.[65] | Minquartia guianensis | Extracts | 4.2 μg/mL (FCR-3) |