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Table 2 Clinical details on patient B (Isolate MAL-1) throughout his hospital stay

From: Acute respiratory distress syndrome and acute renal failure from Plasmodium ovale infection with fatal outcome

Day BP (mmHg) Hb (g/dL) Plt (×103/μl) TSB (μmol/L) AST (IU/L) ALT (IU/L) SCr (μmol/L) Blood bacteriological & fungal culture Anti-malarials Antibiotics Additional notes
1 102/55 12.4 65 16 47 39 100 N/A N/A N/A PR 60 BPM; SPO2 97% RA; loss of appetite; Lungs: clear
2 92/52 N/A N/A N/A N/A N/A 107 N/A Chloroquine N/A PR 70 BPM; Lungs: clear;
Primaquine Dengue IgM negative
3 118/66 N/A 107 13 88 71 112 N/A Chloroquine N/A PR 70 BPM; SPO2 98% RA;
Primaquine Lungs: minimal basal crepitations
4 106/60 10.5 120 13 50 90 101 Negative Artesunate Ceftriaxone PR 66 BPM; Haemoptysis, epistaxis, shortness of breath; CXR: bilateral haziness
Quinine
5 115/56 11.2 170 8 56 62 114 N/A Artesunate Ceftriaxone Blood smear: negative for malaria parasites; Transferred to ICU
6 104/50 9.4 183 6 58 43 139 Negative Artesunate Tazocin® Blood smear: negative for malaria
7 95/56 10.3 197 9 46 42 215 Negative Artesunate Tazocin® Blood smear: negative for malaria
8 102/70 9.4 178 8 88 43 291   Artesunate Tazocin® Blood smear: negative for malaria; respiratory acidosis
Primaquine
9 143/64 9.0 184 7 49 39 297 Negative Artesunate Tazocin® Blood smear: negative for malaria
10 170/60 8.5 199 10 54 48 316 N/A Artesunate Tazocin® Blood smear: negative for malaria
11 165/68 8.1 231 8 99 81 301 N/A N/A Tazocin® Ferritin blood test: 2,118 ng/ml
12 200/78 8.1 288 13 128 148 309 Negative N/A Vancomycin  
Imipenem
13 160/60 6.8 311 16 137 190 392 N/A N/A Vancomycin Hemolysis screening: negative;
Imipenem CXR: worsening
14 170/63 9.1 265 13 47 106 408 N/A N/A Vancomycin  
Imipenem
15 135/51 9.5 270 22 65 74 472 Positive for Enterobacter cloacae N/A Vancomycin Rigours; acidosis (resp. & met.)
Imipenem ABG: pH 7.128; pCO2 59.5 mmHg;
SLED 4 hours
16 111/45 9.1 225 19 43 51 413 N/A N/A Vancomycin CVVHD
Imipenem
17 134/57 7.5 179 29 109 65 424 N/A N/A Vancomycin Seizures; SLED 8 hours
Meropenem
18 135/55 7.3 178 30 38 40 320 N/A N/A Meropenem Gentle HD 4 hours
19 130/56 9.0 204 34 40 30 404 N/A N/A Meropenem Gentle HD 4 hours
20 147/61 8.6 207 25 43 26 403 N/A N/A Meropenem Severe resp. acidosis; met. acidosis; gentle HD 4 hours
21 140/54 N/A N/A N/A N/A N/A 427 N/A N/A Meropenem Gentle HD 3 hours
22 102/48 9.3 166 39 296 119 401 N/A N/A Meropenem Worsening hypoxia; hypotensive; Gentle HD 6 hours
23 N/A N/A N/A 22 136 109 314 N/A N/A N/A Asystole; death
  1. N/A = not available; BP = blood pressure; Hb = haemoglobin; Plt = platelet; TSB = total serum bilirubin; AST = aspartate aminotransferase; ALT = alanine aminotransferase; SCr = serum creatinine; BP = blood pressure; BPM = beats per minute; PR = pulse rate; SPO2 = blood oxygen saturation; RA = room air; IgM = immunoglobulin M; CXR = chest X-ray; ICU = intensive care unit; resp. = respiratory; met. = metabolic; ABG = arterial blood gas; pCO2 = partial pressure of carbon dioxide; SLED = sustained low efficiency dialysis; CVVHD = continuous veno-venous haemodialysis; HD = haemodialysis.