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Table 2 P. knowlesi drug sensitivity data

From: Susceptibility of human Plasmodium knowlesi infections to anti-malarials

Drug IC50values (nM) for P. knowlesi isolates (maturation assay)a IC50values (nM) for P. knowlesi H strain ( p LDH assay)b
Mefloquine 26 (± 3.1) 25 (7.4 to 81)c
Chloroquine 23 (± 4.8) 3.2 (2.2 to 4.7)
Artemisinin 2.1 (± 0.99) 0.80 (0.35 to 1.9)c
Artemether 0.90 (± 0.19) 0.84 (0.34 to 2.1)c
Artesunate 0.90 (± 0.12) 2.0 (0.93 to 4.2)c
DHA 1.6 (± 0.92) 0.79 (0.62 to 1.0)
  1. aMean (± SEM), from 6 independent experiments (each of which was performed in triplicate).
  2. bMean (95% CIs), from a single experiment repeated in quintuplicate.
  3. cR2 < 0.8.
  4. IC50 values are presented for six anti-malarials on P. knowlesi field isolates and laboratory H strain.