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Table 2

From: Human malarial disease: a consequence of inflammatory cytokine release

  Influenza encephalopathy Cerebral malaria
seizures/coma after high grade fever + +
metabolic acidosis + +
hyperlactataemia + +
serum TNF, IL-6, sTNFRI up + +
serum nitrite/nitrate up + +
CSF TNF, IL-6, sTNFRI up + +
multiple organ failure, sequelae + +
thrombocytopaenia + +
damage to vascular endothelial cells + +
brain oedema/damage to BBB + +
apoptosis in neurons/glial cells + +
evidence of active caspase-3 (brain) + +
caspase-cleaved PARP (brain) + +