From: Human malarial disease: a consequence of inflammatory cytokine release
 | Influenza encephalopathy | Cerebral malaria |
---|---|---|
seizures/coma after high grade fever | + | + |
metabolic acidosis | + | + |
hyperlactataemia | + | + |
serum TNF, IL-6, sTNFRI up | + | + |
serum nitrite/nitrate up | + | + |
CSF TNF, IL-6, sTNFRI up | + | + |
multiple organ failure, sequelae | + | + |
thrombocytopaenia | + | + |
damage to vascular endothelial cells | + | + |
brain oedema/damage to BBB | + | + |
apoptosis in neurons/glial cells | + | + |
evidence of active caspase-3 (brain) | + | + |
caspase-cleaved PARP (brain) | + | + |