Table 2 The in vitro IC50 responses of the 65 isolates of Plasmodium falciparum to ferroquine, ferroquine metabolite, chloroquine, artesunate and quinine. Ferroquine cross-resistance with the other antimalarials was estimated by Pearson correlation coefficient (r), and coefficient of determination (r2)
Mean inhibitory concentration (nM) | ||||||
|---|---|---|---|---|---|---|
Drug | No. of isolates | Geometric mean | 95% confidence interval | r | r 2 | P |
Ferroquine | 65 | 9.30 | 8.69 – 9.96 | - | - | - |
FQ-Metabolite | 64 | 37.00 | 34.32 – 39.89 | 0.655 | 0.4288 | 0.0001 |
Chloroquine | 62 | 340.75 | 304.04 – 381.89 | 0.333 | 0.1107 | 0.0090 |
Artesunate | 56 | 4.02 | 3.06 – 6.28 | -0.169 | 0.0284 | 0.2190 |
Quinine | 49 | 1016.05 | 894.36 – 1154.29 | 0.338 | 0.1145 | 0.0200 |