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  • Oral presentation
  • Open Access

Wild chimpanzees are infected with homologous types of human malaria

  • 1, 2,
  • 3,
  • 4,
  • 5,
  • 6, 7,
  • 1 and
  • 8, 9
Malaria Journal20109 (Suppl 2) :O21

https://doi.org/10.1186/1475-2875-9-S2-O21

  • Published:

Keywords

  • Malaria
  • Plasmodium Species
  • Human Malaria
  • Wild Chimpanzee
  • Captive Chimpanzee

Background

Despite ongoing - and in some regions escalating - morbidity and mortality associated with malaria parasites, evolutionary epidemiology of Plasmodium is not well characterized. Recent studies using molecular approaches demonstrated that wild and captive gorillas and captive bonobos and chimpanzees are infected with P. falciparum and that these apes harbor parasites broadly related to P. falciparum[1]. Captive chimpanzees and bonobos had malaria parasites related to human P. ovale and P. malariae and various monkeys and one semi-wild chimpanzee had P. vivax[2]. It is not clear whether these apes harbor naturally these parasites or whether they are transmitted from humans. Most of the examined animals had close contact with humans, comparable studies in wild living apes are missing. We provide the first survey of Plasmodium diversity in wild chimpanzees living in an undisturbed tropical rainforest in Africa.

Methods

We examined tissue from 16 wild West African chimpanzees that lived in the Tai National Park, Ivory Coast, where human contact with animals is limited to researchers who access the territory only during the day. Samples were collected from animals that died primarily from anthrax or respiratory disease. Generic real time PCR assay was used to detect all known Plasmodium species.

Results

11/16 (68%) animals tested positive. Sequence analyses of cytB and 18S rRNA genes identified P. malariae, P. ovale, P. vivax, P. gaboni, P. reichenowi, P. billcollinsi and P. billbraii.

Discussion

Previous examination of the role of our closest phylogenetic relatives, the great apes, in the evolution and persistence of human malarias has been limited by a lack of data from wild ape populations. Interpretation of patterns of malaria infection in captive ape populations must consider ample opportunities for human to ape transmission, negating the opportunity to investigate the evolutionary origins and public health-related risks of these parasites. Our examination of malaria parasites in wild chimpanzees demonstrates that these apes are most likely naturally infected with Plasmodium species homologous to P. malariae, P. vivax and P. ovale as well as P. falciparum. Whether wild great apes are the origin of these malaria types requires further investigation but they may act as reservoir of infection. These results have important implications for global efforts underway to eradicate malaria in humans including vaccine development based on animal variants of human parasites.

Authors’ Affiliations

(1)
Centre for Biological Safety-1; Robert Koch-Institute, D-13353 Berlin-Wedding, Germany
(2)
GenExpress GmbH, D-1 2103 Berlin, Germany
(3)
ImmunoClin Ltd, London, N12 8PE, UK
(4)
Wildlife Conservation Research Unit, Recanati-Kaplan Centre, Department of Zoology, University of Oxford, Tubney, OX13 5QL, UK
(5)
LANADA/ LCPA, BP 206 Bingerville, Ivory Coast
(6)
Department of Environmental Studies and Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, 30322, Georgia, USA
(7)
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, 30322 Georgia, USA
(8)
Research Group Emerging Zoonoses; Robert Koch-Institute, D-13353 Berlin-Wedding, Germany
(9)
Department of Primatology, Max-Planck-Institute for Evolutionary Anthropology, 04103 Leipzig, Germany

References

  1. Prugnolle F, Durand P, Neel C, Ollomo B, Ayala FJ, Arnathau C, Etienne L, Mpoudi-Ngole E, Nkoghe D, Leroy E, Delaporte E, Peeters M, Renaud F: African great apes are natural hosts of multiple related malaria species, including Plasmodium falciparum. Proc Natl Acad Sci USA. 2010, 107: 1458-63. 10.1073/pnas.0914440107.PubMed CentralView ArticlePubMedGoogle Scholar
  2. Krief S, Escalante AA, Pacheco MA, Mugisha L, André C, Halbwax M, Fischer A, Krief JM, Kasenene JM, Crandfield M, Cornejo OE, Chavatte JM, Lin C, Letourneur F, Grüner AC, McCutchan TF, Rénia L, Snounou G: On the diversity of malaria parasites in African apes and the origin of Plasmodium falciparum from Bonobos. PLoS Pathog. 2010, 6: e1000765-10.1371/journal.ppat.1000765.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© Kaiser et al; licensee BioMed Central Ltd. 2010

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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