Volume 9 Supplement 2
Modeling the effects of vector control interventions in reducing malaria transmission, morbidity and mortality
© Boutsika et al; licensee BioMed Central Ltd. 2010
Published: 20 October 2010
Malaria interventions are usually prioritized using efficacy estimates from intervention trials, without considering the context of existing intervention packages or long-term dynamics. We use numerical simulation of mathematical models of malaria in humans and mosquitoes to provide robust quantitative predictions of effectiveness of different strategies in reducing transmission, morbidity and mortality.
We can simulate indoor residual spraying (IRS) and insecticide-treated nets (ITNs), used singly and in combination with each other and with other interventions such as improved case management, intermittent preventive treatment (IPT). We can estimate reductions in entomological inoculation rate (EIR), clinical cases, prevalence and malaria deaths from simulations of different coverage levels ITNs and IRS with different properties, and at different transmission and health system settings.
- Smith T, Killeen DF, Maire N, Ross A, Molineaux L, Tediosi F, Hutton G, Utzinger J, Dietz K, Tanner M: Mathematical modeling of the impact of malaria vaccines on the clinical epidemiology and natural history of Plasmodium falciparum malaria: overview. Am J Trop Med Hyg. 2006, 75 (2 Suppl): 1-10.PubMedGoogle Scholar
- Chitnis N, Smith T, Steketee RW: A mathematical model for the dynamics of malaria in mosquitoes feeding on a heterogeneous host population. J Biol Dyn. 2008, 2: 259-285. 10.1080/17513750701769857.View ArticlePubMedGoogle Scholar
- Chitnis N, Schapira A, Smith T, Steketee R: Comparing the effectiveness of malaria vector control interventions through a mathematical model. Am J Trop Med Hyg. 2010, 83: 230-40. 10.4269/ajtmh.2010.09-0179.PubMed CentralView ArticlePubMedGoogle Scholar
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