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Comparing severity between Plasmodium falciparum malaria and sepsis

  • 1,
  • 2,
  • 1,
  • 1,
  • and
  • 2
Malaria Journal20109 (Suppl 2) :P10

https://doi.org/10.1186/1475-2875-9-S2-P10

  • Published:

Keywords

  • Infectious Disease
  • Malaria
  • High Mortality
  • Failure Rate
  • Organ Failure

Introduction

Malaria is the most important human parasitic disease, affecting about 40% worldwide population, most prevalent in tropical countries. Severe Plasmodium Falciparum Malaria is a cause of ICU in coming, appearing like in Sepsis with multi - organ failure, resulting in high mortality 10-50%. Non-immune patient are most susceptible.

Objectives

Compare severity between severe Plasmodium falciparum Malaria and Sepsis.

Method

Severity between the 18 patients admitted with Severe Plamodium falciparum Malaria and the first 18 patients admitted with Sepsis in ICU -Sagrada Esperança Clinic during 2007 was compared concerning to age, sex, severity ICU scores (SOFA and APACHE II), organ failure and mortality. We also compared mortality between immune and non-immune patients for Malaria.

Results

See tables 1 and 2
Table 1

Comparing severity

 

Malaria n=18

Sepsls n=18

P

Age (X±SD)

39±12

41±13.24

ns

Sex

M: 61%

M: 64%

 

SOFA admission (X)

17

18

ns

SOFA 3rd Day(X)

19

15

ns

SOFA 7th Day(X)

17

9

ns

Apache II

10

12

ns

Mortality

27.8%

47.4%

 
Table 2

Mortality under immunity for Malaria

 

Immune n = 14

Non-immune n=4

Mortality

17%

50%

Table 3

Organ failure

 

Malaria n=18

Sepsis n=18

Neurologic

11.1%

16.7%

Respiratory

0%

16.7%

Hematologic

33.3%

3%

Hepatic

44.4%

33.3%

Hemodynamic

5.6%

27.7%

Renal

33%

33.3%

Conclusion

There is no significant difference for severity comparing severe plasmodium falciparum malaria and Sepsis, there are similar organ failure rate.

Mortality among non-immune patients is high.

Authors’ Affiliations

(1)
Sagrada Esperança Clinic ICU resident, Angola
(2)
Sagrada Esperança Clinic ICU specialist, Angola

References

  1. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI: The global distribuition of clinical episodes of Plasmodium Falciparum malaria. Nature. 2005, 434: 214-217. 10.1038/nature03342.PubMed CentralView ArticlePubMedGoogle Scholar

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