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Comparing severity between Plasmodium falciparum malaria and sepsis


Malaria is the most important human parasitic disease, affecting about 40% worldwide population, most prevalent in tropical countries. Severe Plasmodium Falciparum Malaria is a cause of ICU in coming, appearing like in Sepsis with multi - organ failure, resulting in high mortality 10-50%. Non-immune patient are most susceptible.


Compare severity between severe Plasmodium falciparum Malaria and Sepsis.


Severity between the 18 patients admitted with Severe Plamodium falciparum Malaria and the first 18 patients admitted with Sepsis in ICU -Sagrada Esperança Clinic during 2007 was compared concerning to age, sex, severity ICU scores (SOFA and APACHE II), organ failure and mortality. We also compared mortality between immune and non-immune patients for Malaria.


See tables 1 and 2

Table 1 Comparing severity
Table 2 Mortality under immunity for Malaria
Table 3 Organ failure


There is no significant difference for severity comparing severe plasmodium falciparum malaria and Sepsis, there are similar organ failure rate.

Mortality among non-immune patients is high.


  1. Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI: The global distribuition of clinical episodes of Plasmodium Falciparum malaria. Nature. 2005, 434: 214-217. 10.1038/nature03342.

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Filipe, E.M., Antunes, L., Tomás, E.F. et al. Comparing severity between Plasmodium falciparum malaria and sepsis. Malar J 9 (Suppl 2), P10 (2010).

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