Natural infection of Plasmodium falciparum induces inhibitory antibodies to gametocyte development in human hosts
© Tonwong et al; licensee BioMed Central Ltd. 2010
Published: 20 October 2010
Anti-gametocyte antibodies were elicited during natural malaria infection. The oocyst inhibitory antibodies diffused to and interacted with developing intraerythrocytic gametocytes and reduced number of stage II to V gametocytes, and hampered their maturation. Therefore the alternative development of transmission blocking vaccine in the high transmission area should focus on the identification of the gametocyte antigens inducing inhibitory antibodies to reduce gametocytemia.
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