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Natural infection of Plasmodium falciparum induces inhibitory antibodies to gametocyte development in human hosts
https://doi.org/10.1186/1475-2875-9-S2-P53
© Tonwong et al; licensee BioMed Central Ltd. 2010
- Published: 20 October 2010
Keywords
- Malaria
- Plasmodium Falciparum
- Malaria Infection
- Malaria Patient
- Anopheles Mosquito
Background
The effects of human plasma from malaria patients on maturation of Plasmodium falciparum gametocytes. The data are shown in (A) mean percentages of gametocytes from stage I to V, (B) mean percentages of crisis form of gametocytes, and (C) number of asexual and sexual stage parasites in the cocultivation cultures. (a) malaria naive plasma, (b) oocyst non-inhibitory plasma, (c) oocyst inhibitory plasma, *P ≤ 0.05.
Conclusion
Anti-gametocyte antibodies were elicited during natural malaria infection. The oocyst inhibitory antibodies diffused to and interacted with developing intraerythrocytic gametocytes and reduced number of stage II to V gametocytes, and hampered their maturation. Therefore the alternative development of transmission blocking vaccine in the high transmission area should focus on the identification of the gametocyte antigens inducing inhibitory antibodies to reduce gametocytemia.
Authors’ Affiliations
References
- Bousema JT, Drakeley CJ, Sauerwein RW: Sexual stage antibody responses to P. falciparum in endemic populations. Curr Mol Med. 2006, 6: 223-229. 10.2174/156652406776055140.View ArticlePubMedGoogle Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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