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Figure 1 | Malaria Journal

Figure 1

From: Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics

Figure 1

FK506 in complex with PvFKBD and ternary complex of FK506/PfFKBD/Calcineurin. (A) The electron density map of FK506 at the ligand binding site in PvFKBD. The residues near the FK506 are labeled and displayed as stick model in element colors. (B) Electrostatic surface representation of the residues near the FK506 binding sites in PvFKBD. Positive and negative charges are in blue and red, respectively. (C) Ternary complex model of FK506-bound PfFKBD and calcineurin. PfFKBD (yellow) was overlaid onto FKBP12 (pale cyan) of the FKBP12-FK506-calcineurin ternary complex in order to construct the ternary complex. FK506 is shown in sticks and calcineurin is shown in blue and cyan with its subunits A and B, respectively.

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