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Mechanistic insights into non-immunosuppressive immunophilin ligands as potential antimalarial therapeutics
© Yoon et al; licensee BioMed Central Ltd. 2010
- Published: 20 October 2010
- Antimalarial Drug
- Human Erythrocyte
- Mechanistic Insight
- Antimalarial Activity
Our structure-guided drug screening efforts resulted in an identification of novel adamantanyl-based-antimalarial compound named Supradamal (SRA). SRA exhibits a nanomolar inhibitory activity in both peptidylprolyl cis-trans isomerase (PPIase) assay and growth of P. falciparum cultured in human erythrocytes. In particular, SRA appears to inhibit the trophozoite development.
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