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Modeling the trade-off between effective case management and imported malaria cases in different settings of P. falciparum malaria transmission intensity
© Crowell et al; licensee BioMed Central Ltd. 2010
- Published: 20 October 2010
- Case Management
- Malaria Transmission
- Model Ensemble
- Entomological Inoculation Rate
In many settings, P. falciparum transmission has been greatly reduced due to scaled-up malaria control. Imported cases will continue to be a source of malaria infection when vector control operations are stopped. We investigate the level of surveillance and case management that must be achieved in order to maintain reduced transmission levels, considering a varying rate of importation of cases and initial entomological inoculation rate (EIR).
Simulations were carried out with a model ensemble based on a previously-published individual-based stochastic simulations of the natural history and epidemiology of P. falciparum malaria. As a reference we considered 1000 humans exposed to seasonal transmission based on a Tanzanian setting, with an initial EIR of two infectious bites per person per annum, and importation of infections at a rate of three per annum. Four annual rounds of indoor residual spraying were carried out at the beginning of the simulation and then stopped. Case management was simulated at varying coverages.
Initial results suggest that reductions in malaria transmission in many areas call for a strategy to deal with imported cases as a priority. In the absence of another transmission-blocking intervention, such as a vaccine, high coverage of case management will likely be critical to avoid resurgence of malaria.
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.