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Artemisinin combination therapy mass drug administration in a setting of low malaria endemicity: programmatic coverage and adherence during an observational study in Zanzibar



Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therapy (ACT) in four shehias (smallest administration unit) that had been identified as hotspots through Zanzibar’s malaria case notification surveillance system.


Mass drug administration was done in four shehias selected on the basis of: being an established malaria hot spot; having had mass screening and treatment (MSaT) 2–6 weeks previously; and exceeding the epidemic alert threshold of 5 cases within a week even after MSaT. Communities were sensitized and MDA was conducted using a house-to-house approach. All household members, except pregnant women and children aged less than 2 months, were provided with ACT medicine. Two weeks after the MDA campaign, a survey was undertaken to investigate completion of ACT doses.


A total of 8816 [97.1% of eligible; 95% confidence interval (CI) 96.8–97.5] people received ACT. During post MDA surveys, 2009 people were interviewed: 90.2% reported having completed MDA doses; 1.9% started treatment but did not complete dosage; 4.7% did not take treatment; 2.0% were absent during MDA and 1.2% were ineligible (i.e. infants <2 months and pregnant women). Main reasons for failure to complete treatment were experience of side-effects and forgetting to take subsequent doses. Failure to take treatment was mainly due to fear of side-effects, reluctance due to lack of malaria symptoms and caregivers forgetting to give medication to children.


Mass drug administration for malaria was well accepted by communities at high risk of malaria in Zanzibar, with high participation and completion rates. Further work to investigate the potential of MDA in accelerating Zanzibar’s efforts towards malaria elimination should be pursued.


Malaria was the leading cause of morbidity and mortality in Zanzibar prior to 2003, with malaria endemicity being classified as moderate to high (i.e. parasitaemia among symptomatic patients tested was 35–40%) [1]. In response to the malaria burden, the Zanzibar Malaria Control Programme—in collaboration with bilateral, multilateral and non-governmental partners—scaled up prevention and control efforts, including: artemisinin-based combination therapy (ACT); insecticide-treated nets (ITNs); indoor residual spraying of households with insecticide (IRS); and intermittent preventive treatment for pregnant women (IPTp) with sulfadoxine–pyrimethamine (SP) [2,3,4]. Over the past decade these efforts changed malaria endemicity in Zanzibar from hyper- to hypo-endemic, with parasite prevalence dropping to and being maintained at <1% for the previous 3 years [1, 4].

Building on the success of these efforts and in alignment with global guidance [5], Zanzibar is now targeting malaria elimination on both Unguja and Pemba islands: the goal is to achieve zero locally acquired cases by 2018 by achieving and maintaining 100% coverage with appropriate prevention measures [6]. While malaria elimination relies upon a similar mix of interventions as during the malaria control phase (i.e. case management, vector control, and surveillance), it requires more intensified, rapid, and targeted responses, especially for targeting transmission hotspots and specific high-risk populations [7,8,9]. The Zanzibar Malaria Elimination Programme (ZAMEP) is able to identify hotspots through its malaria case notification (MCN) (“Coconut”) surveillance system, which tracks daily facility-based malaria cases for real-time decision-making and active case detection through household screening and treatment (HSaT).

One potential strategy for targeted interventions in a malaria elimination setting is focal mass drug administration (MDA) in high-risk populations. Although falling out of favour due to efficacy concerns during the eradication era in the 1960s, MDA has re-emerged as a potential strategy for malaria elimination and eradication [10, 11]. Use of MDA since the eradication era has mainly been preventative therapy and seasonal chemoprevention; however, an argument for MDA is that diagnosis can be hampered by lack of biomarkers of the liver stage of malaria and limitations of currently available detection methods for lower density blood stage infections [12, 13]. A recent systematic literature review found that: (1) MDA has been used in large-scale malaria control, elimination and outbreak response efforts, with community participation and at least 80% coverage of the target population being important factors for a successful MDA campaign; (2) MDA and mass chemoprophylaxis probably contributed to reducing parasite prevalence in certain intervention settings; and (3) select MDA programmes have been considered successful based on qualitative assessments other than efficacy [14]. Renewed interest in MDA as an approach for interrupting transmission is based on the availability of effective anti-malarial drugs with transmission reducing characteristics as well as mathematic modeling studies showing the epidemiological impact of the intervention in settings with low transmission intensity and during periods of low vector densities [15]. However, there is evidence to suggest that effectiveness of MDA is often not sustained beyond 6 months [16].

Taking into account the current pre-elimination setting of Zanzibar, MDA might have a significant effect when used focally in areas at risk of high-transmission, especially before the peak malaria transmission season. This study reports on programmatic coverage and compliance of MDA using ACT in four shehias (the smallest administrative unit in Zanzibar comprising of 2000–5000 population) that had been identified as hotspots through Zanzibar’s MCN surveillance system.


Study settings

There are 331 shehias in Zanzibar, of which four were purposively selected for the MDA intervention, because they: (1) were established malaria transmission hotspots with annual malaria incidence >20/1000 population; (2) had received mass screening and treatment (MSaT) 2–6 weeks earlier; and (3) had exceeded the epidemic alert threshold of 5 cases or more reported within a week even after MSaT intervention, with MDA considered as an additional intervention [17]. Figure 1 shows the location of the shehias where the MDA was undertaken in June 2013: Finya and Chimba are located in Micheweni District of Pemba, while Uzi and Ng’ambwa is a peninsula in the South District of Unguja.

Fig. 1
figure 1

Map of Zanzibar showing the MDA shehias

MDA implementation

Drug used for MDA

Table 1 shows the ACT preparations and dosages used during the MDA. The main ACT used was dihydroartemisinin/piperaquine phosphate (Duo-Cotecxin®, Beijing Holley-Cotec Pharmaceutical Co Ltd, China). In Uzi and Ng’ambwa, artemisinin and piperaquine (Artequick®, Artepharm, China) was also dispensed due to shortages of Duo-Cotecxin. Duo-cotecxin and Artequick® were considered appropriate for the MDA pilot, because both are not used in the routine treatment of malaria in Zanzibar. However, based on the manufacturers recommendations, Duo-Cotecxin® 40/320 mg tablets is not suitable for children aged <6 months while Artequick® 62.5/375 mg tablets is not suitable for children age <7 years [18, 19]; therefore, artesunate–amodiaquine (ASAQ) Winthrop® was dispensed instead.

Table 1 List of ACT preparations and dosages used during the MDA

Population eligible for MDA

All people living in the MDA pilot areas were eligible for treatment, except infants <2 months of age, and pregnant women in the first trimester of pregnancy.


In each shehia, ten teams comprising of a healthcare worker (i.e. drug dispenser), an administration leader (i.e. local guide) and a recorder (to complete MDA monitoring forms) were trained to conduct MDA. In addition to the drug distribution team, a team comprising a health promotion specialist and a local guide were allocated to each shehia to conduct community mobilization and top-up ITN distribution on the day of the MDA. A days’ training was conducted to drug distribution teams with the objective of explaining the rationale and importance of MDA, filling MDA forms and dispensing of ACT.

Community mobilization

Two days prior to MDA implementation, a series of community mobilization events were undertaken in each shehia, including radio programmes on malaria prevention and response activities, house-to-house communication through local leaders, and public announcements through town criers. The information focused on what, why, when and how MDA would be carried out. Information leaflets on the MDA activity and malaria prevention in Swahili language were also distributed in the target shehias. After the MDA, public announcements continued on the second and the third day with messages targeted at reminding communities to take the second and the thirds ACT doses. Information on malaria prevention through consistent use of bed nets was also delivered.

Drug distribution

The MDA was undertaken from house-to-house. In each household, all members were enumerated. Women of child-bearing age were asked if they were in the first trimester of pregnancy to determine eligibility for treatment. All eligible persons present were offered ACT, with the first dose being taken as a directly observed treatment (DOT). Dosage for subsequent days (day 2 and 3) was dispensed in packets labeled with the name for each eligible recipient. For those that were not present during the household visit, drugs were dispensed in a labeled packet and left with the head of the household. Instructions on when the subsequent doses would be taken were provided to all MDA adult participants. Parents and guardians were provided with information on dosing of children. After the MDA, public announcements were done in the community on days 2 and 3 post-MDA reminding participants to take the dose for the respective day.

Post MDA survey

Two weeks after the MDA, a survey was done to estimate completion of ACT doses distributed; investigate reasons for not completing MDA doses; investigate side-effects following MDA; and explore willingness of participants to take part in MDAs in the future.

Using an internet-based sample size calculator (, sample size was calculated to estimate 50% completion of all three MDA doses within a 5% error margin, given a 5% level of significance and 95% confidence level. Calculations were adjusted for a design effect of 2.0 to allow for household clustering of observations, as well as a 10% non-response rate, yielding a minimum sample size of 750 individuals required per shehia. Assuming—based on operational programme implementation experience—a household size of 5, at least 150 households were required to be surveyed in each shehia. A list of all households that would be eligible to participate in the MDA was obtained for each shehia. To ensure the sample’s uniform distribution across the shehia, household lists were ordered by sub-shehia prior to 150 households being selected using systematic random sampling.

Data collection and analysis

Customized forms were designed to collect data during the MDA distribution and post-MDA survey. MDA monitoring forms included a household census, eligibility for participation in MDA and ACT dosage. Post MDA forms included a household census, questions on MDA participation, reasons for MDA non-completion, side-effects and willingness to participate in MDA in the future. Data were completed by health care workers who were experienced in undertaking household surveys and who had received a day’s training on the survey protocol. Data from the MDA monitoring form and post-MDA survey were entered using Microsoft Excel® (Microsoft Corporation, Redmond, WA) spreadsheets. Statistical analysis was conducted using Stata 12.0 (Stata Corporation, College Station, TX). Data for Uzi and Ng’ambwa were combined together for analysis, because the two shehia comprise a peninsula on Unguja. Descriptive statistics were used to summarize the age and gender distribution of the MDA populations and post-MDA sample, MDA treatment coverage and MDA completion. Differences in proportions were compared using the χ2 test.


Age and gender characteristics of study population

A total of 9076 participants in 2001 households were enumerated in the four districts targeted for MDA; a total of 2009 participants were enumerated in 413 households during the post MDA survey. Compared to Chimba and Finya, the mean age of the population of Uzi and Ng’ambwa was slightly higher; however, there was no statistically significant difference in the gender distribution across shehias (Table 2).

Table 2 Age and gender characteristics of population participating in MDA and sample of post MDA participants

MDA treatment coverage

Overall, a total of 8816 out 9076 [97.1%; 95% confidence interval (CI) 96.8–97.5] people enumerated received treatment, with MDA coverage between districts not significantly different, ranging from 95.7%; (95% CI 94.0–96.4) in Uzi and Ng’ambwa to 98.0% (95% CI 97.4–98.4) in Chimba. Of the 260 people that did not receive treatment, the majority (65.8%) were absent from the household at the time of the MDA; the remainder were not eligible to receive treatment [i.e. infants under 2 months of age (14.6%) and pregnant women in the first trimester (19.6%)] (Table 3; Fig. 2).

Table 3 MDA treatment coverage by shehia
Fig. 2
figure 2

Consort chart of study

MDA treatment completion

A sample of 2009 people were interviewed during post-MDA survey, of whom: 90.2% reported having completed MDA doses; 1.9% started treatment but did not complete dosage; 4.7% received medicine but did not take treatment; 2.0% did not receive medicine, because they were absent during MDA; and 1.2% were not eligible to receive treatment (infants and first trimester pregnant women) (Table 4; Fig. 2). Of the 38 people not completing treatment, two fifths did not provide any reason; the remainder provided a range of reasons for non-compliance, including experienced side-effects, fear of side-effects, and forgetting to take treatment. Reasons for failure to take treatment were: fear of side-effects; did not have fever; forgot to take treatment or forgot give treatment to children; fasting; busy with daily chores; and insufficient information about MDA. A total of 94 (i.e. 5.2% of those taking treatment) reported side-effects including: muscular aches (22.3%); dizziness (21.3%); abdominal pain (16.0%); vomiting (11.7%); headache (9.6%); fever (5.3%); sneezing (4.3%); diarrhoea (3.2%); nausea (3.2%); other (3.2%). The majority (94.2%) of 2009 survey participants reported that they would take part in MDA in the future.

Table 4 MDA completion of ACT doses in Chimba, Finya, Uzi and Ng’ambwa shehias


This study presents findings on the community’s acceptability, completion and perceptions after focal MDA with ACT intended to mitigate increased seasonal malaria transmission in Zanzibar. MDA was conducted within communities as a response to an increase in malaria cases in the four shehias defined as hotspots where MDA was recommended because—although MSaT had been done a few weeks prior—the number of malaria cases in these shehias continued to increase. The rationale for MDA was to provide appropriate treatment to clear malaria parasites in the population so as to prevent on-going transmission in malaria hotspots with intense transmission. The findings of the pilot presented here showed high MDA participation (97.1%) and acceptance by the communities targeted, with high completion of ACT doses (90.2%) among participants who received the medication. This finding was most likely attributed to the intensive community sensitization and mobilization activities that took place prior to the MDA, including the house-to-house approach as well as the post-MDA public announcements to remind people to complete subsequent doses. The findings also suggest that community sensitization was effective, as the majority (94.2%) of survey participants reporting that they would take part in future MDAs. This suggests that MDA can be considered as a practical intervention in persisting malaria hotspots, particularly if active case detection efforts such as MSaT and HSaT fail to adequately curb transmission.

The post-MDA survey findings showed that the reasons for failure to complete the ACT doses were fear of side-effects such as abdominal pain, headaches, vomiting, dizziness, sneezing, muscular aches, fever, nausea and body malaise. Similar findings were observed in studies conducted in The Gambia where barriers of the MDA campaign included the perception and fear of the community members on the side-effects of the drugs and procedures [20, 21]. These misconceptions by the participants and misunderstandings about the medication can contribute greatly to the lack of adherence to an MDA [22]. Similarly, fear of side-effects from the drugs leading to decreased MDA coverage has also been reported in MDA for other parasitic diseases, e.g. lymphatic filariasis [23,24,25,26,27]. Other reasons for non-compliance reported by participants in Zanzibar included: forgetting to take treatment; insufficient information about MDA; reluctance to take drugs without malaria symptoms; fasting; and busy with daily chores. The number of pills required for a full ACT regimen has also been shown to discourage adherence to the MDA programme [28]. Single dose treatment, possibly under DOT, could enhance compliance for malaria MDA.

As neglected tropical disease MDAs have shown in multiple countries [29,30,31], in order to maximize MDA participation, misconception and fears of side-effects within the target population need to be addressed at the start of the activity and frequent communication should be maintained throughout the MDA period through community education and training of health care workers [14, 26, 32]. This is particularly salient if several rounds of MDA were to be conducted in order to have a more lasting impact on malaria transmission. In addition, community sensitization should involve village leaders to enhance participation from community members [20]. The importance of educating the target community with correct information regarding the drug, procedures to be taken and the possible side-effects helps to enhance adherence. The results of this study show that MDA is a practical response intervention in low transmission settings; however, further research is needed to investigate the effectiveness of MDA in the four shehias.

This is the first study to pilot MDA as an intervention for malaria elimination in Zanzibar. The study has several potential limitations. Firstly, the pilot was done in a few shehias selected purposively and, therefore, may not be generalizable to the whole of Zanzibar. Secondly, compliance for treatment was measured based on self-reports by the participants, which may be subject to recall bias or over-reporting. Finally, the study was designed as a feasibility study embedded in a larger operational program, and not as an efficacy study to measure the impact of MDA on malaria morbidity and/or transmission. If MDA does become part of the intervention package to ensure malaria transmission remains low, particularly in hotspots, then a robust monitoring and evaluation framework and protocol to measure the intervention’s efficacy will have to be designed.


This study demonstrates that MDA for malaria was feasible and highly accepted by communities at high risk of malaria in Zanzibar, with high participation and completion rates, even though they had recently been targeted for MSaT. Together with other preventative measures, MDA has the potential to contribute to interrupting transmission of malaria and accelerate ZAMEP’s efforts towards malaria elimination.



artemisinin-based combination therapy


mass drug administration


  1. Bhattarai A, Ali AS, Kachur SP, Mårtensson A, Abbas AK, Khatib R, et al. Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar. PLoS Med. 2007;4:e309.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Aregawi MW, Ali AS, Al-mafazy A, Molteni F, Katikiti S, Warsame M, et al. Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999–2008. Malar J. 2011;10:46.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Programme Zanzibar Malaria Control. Malaria elimination in Zanzibar: a feasibility assessment. Zanzibar: Zanzibar Malaria Control Programme; 2009.

    Google Scholar 

  4. Tanzania Commission for AIDS (TACAIDS), Zanzibar AIDS Commission (ZAC), National Bureau of, Statistics (NBS), Office of the Chief Government Statistician (OCGS), and ICF International. Tanzania HIV/AIDS and Malaria Indicator Survey 2011–12. Dar es Salaam, Tanzania: TACAIDS, ZAC, NBS, OCGS, and ICF International; 2013.

  5. WHO, Global Malaria Programme. Disease surveillance for malaria elimination: an operational manual. Geneva: World Health Organization; 2012.

    Google Scholar 

  6. Zanzibar Malaria Control Programme, Ministry of Health and Social Welfare. Roll back malaria indicator survey, 2007: main report. Zanzibar: Zanzibar Malaria Control Programme; 2008.

    Google Scholar 

  7. Moonen B, Cohen JM, Snow RW, Slutsker L, Drakeley C, Smith DL, et al. Operational strategies to achieve and maintain malaria elimination. Lancet. 2010;376:1592–603.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Bousema T, Griffin JT, Sauerwein RW, Smith DL, Churcher TS, Takken W, et al. Hitting hotspots: spatial targeting of malaria for control and elimination. PLoS Med. 2012;9:e1001165.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Sturrock HJW, Hsiang MS, Cohen JM, Smith DL, Greenhouse B, Bousema T, et al. Targeting asymptomatic malaria infections: active surveillance in control and elimination. PLoS Med. 2013;10:e1001467.

    Article  PubMed  PubMed Central  Google Scholar 

  10. malERA Consultative Group on Drugs. A research agenda for malaria eradication: drugs. PLoS Med. 2011;8:e1000402.

    Article  Google Scholar 

  11. Cotter C, Sturrock HJW, Hsiang MS, Liu J, Phillips AA, Hwang J, et al. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet. 2013;382:900–11.

    Article  PubMed  Google Scholar 

  12. Bardají A, Bassat Q, Alonso PL, Menéndez C. Intermittent preventive treatment of malaria in pregnant women and infants: making best use of the available evidence. Expert Opin Pharmacother. 2012;13:1719–36.

    Article  PubMed  Google Scholar 

  13. Douglas NM, John GK, von Seidlein L, Anstey NM, Price RN. Chemotherapeutic strategies for reducing transmission of Plasmodium vivax malaria. Adv Parasitol. 2012;80:271–300.

    Article  PubMed  Google Scholar 

  14. Newby G, Hwang J, Koita K, Chen I, Greenwood B, von Seidlein L, et al. Review of mass drug administration for malaria and its operational challenges. Am J Trop Med Hyg. 2015;93:125–34.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Okell LC, Griffin JT, Kleinschmidt I, Hollingsworth TD, Churcher TS, White MJ, et al. The Potential contribution of mass treatment to the control of Plasmodium falciparum malaria. PLoS ONE. 2011;6:e20179.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. Cochrane Database Syst Rev. 2013; CD008846.

  17. Programme Zanzibar Malaria Control. MEEDS & MCN Quarterly report: Quarter 2, April to June 2013. Zanzibar: Zanzibar Malaria Control Programme; 2013.

    Google Scholar 

  18. Beijing Holley-Cotec Pharmaceuticals. Duo-cotecxin®: Dihydroartemisinin and Piperaquine Phosphate (40/320 mg). Accessed on 29 July 2017.

  19. Artepharm Co Ltd. Artequick®: A new generation of artemisinin combination. Accessed on 29 July 2017.

  20. Dial NJ, Ceesay SJ, Gosling RD, D’Alessandro U, Baltzell KA. A qualitative study to assess community barriers to malaria mass drug administration trials in The Gambia. Malar J. 2014;13:47.

    Article  PubMed  PubMed Central  Google Scholar 

  21. De Martin S, von Seidlein L, Deen JL, Pinder M, Walraven G, Greenwood B. Community perceptions of a mass administration of an antimalarial drug combination in The Gambia. Trop Med Int Health. 2001;6:442–8.

    Article  PubMed  Google Scholar 

  22. Kaneko A. A community-directed strategy for sustainable malaria elimination on islands: short-term MDA integrated with ITNs and robust surveillance. Acta Trop. 2010;114:177–83.

    Article  PubMed  Google Scholar 

  23. Roy RN, Sarkar AP, Misra R, Chakroborty A, Mondal TK, Bag K. Coverage and awareness of and compliance with mass drug administration for elimination of lymphatic filariasis in Burdwan District, West Bengal, India. J Health Popul Nutr. 2013;31:171–7.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Ghosh S, Kole S, Samanta A. Mass drug administration for elimination of lymphatic filariasis: recent experiences from a district of West Bengal. India. Trop Parasitol. 2013;3:67.

    Article  PubMed  Google Scholar 

  25. Bhullar N, Maikere J. Challenges in mass drug administration for treating lymphatic filariasis in Papua, Indonesia. Parasit Vectors. 2010;3:70.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Cantey PT, Rout J, Rao G, Williamson J, Fox LM. Increasing compliance with mass drug administration programs for lymphatic filariasis in India through education and lymphedema management programs. PLoS Negl Trop Dis. 2010;4:e728.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Njomo DW, Amuyunzu-Nyamongo M, Magambo JK, Njenga SM. The role of personal opinions and experiences in compliance with mass drug administration for lymphatic filariasis elimination in Kenya. PLoS ONE. 2012;7:e48395.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Lemma H, Löfgren C, San Sebastian M. Adherence to a six-dose regimen of artemether-lumefantrine among uncomplicated Plasmodium falciparum patients in the Tigray Region,Ethiopia. Malar J. 2011;10:349.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Narain JP, Dash AP, Parnell B, Bhattacharya SK, Barua S, Bhatia R, et al. Elimination of neglected tropical diseases in the South-East Asia Region of the World Health Organization. Bull World Health Organ. 2010;88:206–10.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Dembélé M, Bamani S, Dembélé R, Traoré MO, Goita S, Traoré MN, et al. Implementing preventive chemotherapy through an integrated National Neglected Tropical Disease Control Program in Mali. PLoS Negl Trop Dis. 2012;6:e1574.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Lemoine JF, Desormeaux AM, Monestime F, Fayette CR, Desir L, Direny AN, et al. Controlling neglected tropical diseases (NTDs) in Haiti: implementation strategies and evidence of their success. PLoS Negl Trop Dis. 2016;10:e0004954.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Garfield RM, Vermund SH. Health education and community participation in mass drug administration for malaria in Nicaragua. Soc Sci Med. 1982;1986(22):869–77.

    Google Scholar 

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Authors’ contributions

ASA, BK, HHA, JS, MM, AWAM, IAG, JMK, LAP and JMN designed study and supervised data collection during MDA and post-MDA survey. NGT, MMR, HM, RR and JMN undertook data analysis and drafted manuscript, which all authors reviewed and approved. All authors read and approved the final manuscript.


We are grateful to the health care workers and the administration in the shehias targeted for MDA.

Competing interests

The authors declare that they have no competing interests.

Availability of data and materials

The datasets generated during the current study are available from the corresponding author on reasonable request.

Consent for publication

Not applicable.


The findings and conclusions presented in this manuscript are those of the authors and do not necessarily reflect the official position of the US President’s Malaria Initiative, US Agency for International Development, or US Centers for Disease Control and Prevention.

Ethical approval and consent to participate

This MDA was undertaken as part of a larger public health programmatic activity—therefore, it was not submitted for ethical clearance a priori. Permission to publish the data was granted by the Zanzibar Medical Research Ethical Committee (ZAMREC). All personal identifiers were removed from the data before analyses were undertaken.


This study was made possible through support provided to the Tanzania Vector Control Scale-up Project [Cooperative Agreement 621-A-00-10-00015-00] by the President’s Malaria Initiative (PMI) via the U.S. Agency for International Development (USAID) and an inter-agency agreement with the U.S. Centers for Disease Control and Prevention (CDC). The opinions expressed herein are those of the author(s) and do not necessarily reflect the views of USAID, CDC, or other employing organizations or sources of funding.

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Ali, A.S., Thawer, N.G., Khatib, B. et al. Artemisinin combination therapy mass drug administration in a setting of low malaria endemicity: programmatic coverage and adherence during an observational study in Zanzibar. Malar J 16, 332 (2017).

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