Skip to main content

Table 2 Overview of clinical and parasitological parameters assessed for volunteer 2

From: Two cases of long-lasting, sub-microscopic Plasmodium malariae infections in adults from coastal Tanzania

 

Study enrolment

Routine visit 1

Routine visit 2

qPCR results reported

Post-treatment visit 1

Post-treatment visit 2

Timeline

 Date

22/12/2015

13/02/2016

13/04/2016

28/04/2016

06/05/2016

01/07/2016

 Days respective to enrolment into clinical trial

0

53

113

128

136

192

Clinical evaluation

 Body temperature

36.5 °C

36.8 °C

36.7 °C

36.6 °C

–

36.4 °C

 Vital signs including pulse, blood pressure and respiration rate

NAD

NAD

NAD

NAD

–

NAD

Laboratory evaluation

 Biochemistry including ALT, AST

NAD, also included BIL and CRE at enrolment

NAD

NAD

NAD

–

NAD

 Complete blood count includes RBC, HGB, HCT, MCV, MCH, MCHC, PLT, WBC with differential

EO ↑ (1.19 × 103/µL, 18.1%)

EO ↑ (1.04 × 103/µL, 17.2%)

EO ↑ (1.06 × 103/µL, 12.0%) RDW-SD ↓ (34.4 fL)

EO ↑ (0.63 × 103/µL, 6.5%)

WBC ↑ (9.65 × 103/µL) NEUT ↑ (6.07 × 103/µL, 62.9%)

–

EO ↑ (0.77 × 103/µL, 12.0%) RDW-SD ↓ (33.6 fL)

 Urine analysis using dipstick that includes bilirubin, ketone, creatinine, hematuria, proteinuria, albumin, nitrite, leucocytes, glucose, specific gravity, pH, vitamin C

NAD

NAD

NAD

NAD

–

Proteinuria (trace)

 Serology (HIV, HBV, HCV)

Negative

–

–

–

–

–

 Screening for intestinal helminths and schistosomiasis

Negative

–

–

–

–

–

Malaria diagnostics

 Thick blood smear microscopy

Negative

Negative

Negative

Negative

Negative

Negative

 Screening and species identification qPCR assays

Screening qPCR: Cq of 31.62 ID-qPCR: P. malariae

Screening qPCR: Cq of 32.78 ID-qPCR: P. malariae

Screening qPCR: Cq of 33.44 ID-qPCR: P. malariae

Screening qPCR: Cq of 34.47 ID-qPCR: P. malariae

Screening qPCR: neg

Screening qPCR: neg

Drug treatment

 Prescription of drugs throughout the clinical trial

–

–

–

Start of artesunate-amodiaquine based treatment on 02/05/2016

–

–

  1. NAD no abnormalities detected