Fig. 1
From: Limited Plasmodium sporozoite gliding motility in the absence of TRAP family adhesins
Generation of parasite lines lacking multiple TRAP family adhesins. A Overview cartoon showing the effect of single knockouts of TRAP, TLP or TREP on Plasmodium sporozoite live cycle progression. trap(-) parasites are nearly completely blocked in salivary gland colonization. trep(-) parasites show a severe reduction in salivary gland colonization, but those that get in can progress normally. tlp(-) show no defect in salivary gland colonization but a small defect in migration in the skin. trap(-) parasites isolated from oocysts also cannot enter into the liver. Bars show expression of the different genes. B Flow chart illustrating the transgenesis strategy used to generate double and triple knockout parasites