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  1. Malaria remains a leading cause of morbidity, mortality and non-fatal disability in Zambia, especially among children, pregnant women and the poor. Data gathered by the National Malaria Control Centre has show...

    Authors: Pascalina Chanda, Felix Masiye, Bona M Chitah, Naawa Sipilanyambe, Moonga Hawela, Patrick Banda and Tuoyo Okorosobo

    Citation: Malaria Journal 2007 6:21

    Content type: Research

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  2. Open access to databases of information generated by the research community can synergize individual efforts and are epitomized by the genome mapping projects. Open source models for outputs of scientific rese...

    Authors: Carlos A Guerra, Simon I Hay, Lorena S Lucioparedes, Priscilla W Gikandi, Andrew J Tatem, Abdisalan M Noor and Robert W Snow

    Citation: Malaria Journal 2007 6:17

    Content type: Review

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  3. Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP...

    Authors: Andrew Vallely, Lisa Vallely, John Changalucha, Brian Greenwood and Daniel Chandramohan

    Citation: Malaria Journal 2007 6:16

    Content type: Review

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  4. An increasing number of countries in sub-Saharan Africa are changing to artemisinins combination therapy (ACT) as first or second line treatment for malaria. There is an urgent need to assess the safety of the...

    Authors: Stephanie Dellicour, Susan Hall, Daniel Chandramohan and Brian Greenwood

    Citation: Malaria Journal 2007 6:15

    Content type: Review

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  5. Coverage of vulnerable groups with insecticide-treated nets (ITNs) in Ghana, as in the majority of countries of sub-Saharan Africa is currently low. A voucher scheme was introduced in Volta Region as a possibl...

    Authors: Margaret Kweku, Jayne Webster, Ian Taylor, Susan Burns and McDamien Dedzo

    Citation: Malaria Journal 2007 6:14

    Content type: Research

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  6. An ITN intervention was initiated in three predominantly rural districts of Eastern Province, Zambia, that lacked commercial distribution and communication infrastructures. Social marketing techniques were use...

    Authors: Sohail Agha, Ronan Van Rossem, Guy Stallworthy and Thankian Kusanthan

    Citation: Malaria Journal 2007 6:13

    Content type: Research

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  7. Artemisinin-derivative formulations are now widely used to treat falciparum malaria. However, the dry powder suspensions developed for children are few and/or are of poor quality. In addition to the active com...

    Authors: Magnus A Atemnkeng, Katelijne De Cock and Jacqueline Plaizier-Vercammen

    Citation: Malaria Journal 2007 6:12

    Content type: Research

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  8. Uganda was the first country to scale up Home Based Management of Fever/Malaria (HBM) in 2002. Under HBM pre-packaged unit doses with a combination Sulphadoxine/Pyrimethamin (SP) and Chloroquine (CQ) called "H...

    Authors: Xavier Nsabagasani, Jesca-Nsungwa-Sabiiti, Karin Källander, Stefan Peterson, George Pariyo and Göran Tomson

    Citation: Malaria Journal 2007 6:11

    Content type: Research

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  9. Insecticide Treated Nets (ITNs) are an important tool for malaria control. ITNs are effective because they work on several parts of the mosquito feeding cycle, including both adult killing and repelling effects.

    Authors: Arnaud Le Menach, Shannon Takala, F Ellis McKenzie, Andre Perisse, Anthony Harris, Antoine Flahault and David L Smith

    Citation: Malaria Journal 2007 6:10

    Content type: Research

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  10. The Human Blood Index (HBI, proportion of bloodmeals of a mosquito population obtained from man) is relevant to epidemiological assessment and to the modification of measures to interrupt malaria transmission ...

    Authors: Frédéric Lardeux, Paola Loayza, Bernard Bouchité and Tamara Chavez

    Citation: Malaria Journal 2007 6:8

    Content type: Research

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  11. Presumptive treatment of malaria in febrile children is widely advocated in Africa. This may occur in the absence of diagnostic testing or even when diagnostic testing is performed but fails to detect malaria ...

    Authors: Denise Njama-Meya, Tamara D Clark, Bridget Nzarubara, Sarah Staedke, Moses R Kamya and Grant Dorsey

    Citation: Malaria Journal 2007 6:7

    Content type: Research

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  12. Members of Anopheles maculipennis complex are effective malaria vectors in Europe and the Caspian Sea region in northern Iran, where malaria has been re-introduced since 1994. The current study has been designed ...

    Authors: Navid D Djadid, Saber Gholizadeh, Elham Tafsiri, Roberto Romi, Mikhail Gordeev and Sedigheh Zakeri

    Citation: Malaria Journal 2007 6:6

    Content type: Research

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  13. Conventional methods of assessing in-vitro antimalarial drug-concentration effect relationships in field testing of fresh isolates assess each parasite isolate individually. This leads to systematic overestima...

    Authors: Kasia Stepniewska, Kesinee Chotivanich, Alan Brockman, Nicholas PJ Day and Nicholas J White

    Citation: Malaria Journal 2007 6:4

    Content type: Review

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  14. Epidemiological studies of malaria in adults who live in malaria endemic areas are scarce. More attention to the natural history of malaria affecting adults is needed to understand the dynamics of malaria infe...

    Authors: Alfredo Mayor, John J Aponte, Carole Fogg, Francisco Saúte, Brian Greenwood, Martinho Dgedge, Clara Menendez and Pedro L Alonso

    Citation: Malaria Journal 2007 6:3

    Content type: Research

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  15. In Tanzania, drug-resistant malaria parasites are an increasing public health concern. Because of widespread chloroquine (CQ) resistance Tanzania changed its first line treatment recommendations for uncomplica...

    Authors: Mirjam Schönfeld, Isabel Barreto Miranda, Mirjam Schunk, Ibrahim Maduhu, Leonard Maboko, Michael Hoelscher, Nicole Berens-Riha, Andrew Kitua and Thomas Löscher

    Citation: Malaria Journal 2007 6:2

    Content type: Research

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  16. There is an increase of serum levels of IgE during Plasmodium falciparum infections in individuals living in endemic areas. These IgEs either protect against malaria or increase malaria pathogenesis. To get an in...

    Authors: Joana Duarte, Prakash Deshpande, Vincent Guiyedi, Salah Mécheri, Constantin Fesel, Pierre-André Cazenave, Gyan C Mishra, Maryvonne Kombila and Sylviane Pied

    Citation: Malaria Journal 2007 6:1

    Content type: Research

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  17. Polymerase chain reactions to distinguish single-nucleotide polymorphisms are commonly used for mosquito identification and identifying insecticide resistance alleles. However, the existing methods used for pr...

    Authors: Elien E Wilkins, Paul I Howell and Mark Q Benedict

    Citation: Malaria Journal 2006 5:125

    Content type: Methodology

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  18. Home-based management of fever (HBMF) could improve prompt access to antimalarial medicines for African children. However, the perception of treatment failure by caregivers has not been assessed.

    Authors: Mugagga Malimbo, Erieza Mugisha, Fred Kato, Charles Karamagi and Ambrose O Talisuna

    Citation: Malaria Journal 2006 5:124

    Content type: Research

    Published on:

  19. Health education is an important component in disease control programme. Kalajatha is a popular, traditional art form of folk theatre depicting various life processes of a local socio-cultural setting. It is an e...

    Authors: Susanta K Ghosh, Rajan R Patil, Satyanarayan Tiwari and Aditya P Dash

    Citation: Malaria Journal 2006 5:123

    Content type: Case study

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  20. The use of genotyping to distinguish recrudescent from new infections is currently recommended for all clinical antimalarial efficacy trials by the World Health Organization. However, genotyping-adjusted drug ...

    Authors: William J Collins, Bryan Greenhouse, Philip J Rosenthal and Grant Dorsey

    Citation: Malaria Journal 2006 5:122

    Content type: Research

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  21. The main objective of this study was to compare the performance of nested PCR with expert microscopy as a means of detecting Plasmodium parasites during active malaria surveillance in western Thailand.

    Authors: Russell E Coleman, Jetsumon Sattabongkot, Sommai Promstaporm, Nongnuj Maneechai, Bousaraporn Tippayachai, Ampornpan Kengluecha, Nattawan Rachapaew, Gabriela Zollner, Robert Scott Miller, Jefferson A Vaughan, Krongtong Thimasarn and Benjawan Khuntirat

    Citation: Malaria Journal 2006 5:121

    Content type: Research

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  22. Recent studies have highlighted the over-diagnosis of malaria in clinical settings in Africa. This study assessed the impact of a training programme implemented as part of an intervention trial on diagnostic b...

    Authors: Paul M Masika, Waziri J Semarundu, Raymond Urassa, Jackline Mosha, Daniel Chandramohan and Roly D Gosling

    Citation: Malaria Journal 2006 5:120

    Content type: Case study

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  23. Plasmodium falciparum can be detected by microscopy, histidine-rich-protein-2 (HRP2) capture test or PCR but the respective clinical relevance of the thereby diagnosed infections in pregnant women is not well est...

    Authors: Frank P Mockenhaupt, George Bedu-Addo, Christiane von Gaertner, Renate Boyé, Katrin Fricke, Iris Hannibal, Filiz Karakaya, Marieke Schaller, Ulrike Ulmen, Patrick A Acquah, Ekkehart Dietz, Teunis A Eggelte and Ulrich Bienzle

    Citation: Malaria Journal 2006 5:119

    Content type: Research

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  24. Accurate identification and quantification of malaria parasites are critical for measuring clinical trial outcomes. Positive and negative diagnosis is usually sufficient for the assessment of therapeutic outco...

    Authors: Wendy Prudhomme O'Meara, Mazie Barcus, Chansuda Wongsrichanalai, Sinuon Muth, Jason D Maguire, Robert G Jordan, William R Prescott and F Ellis McKenzie

    Citation: Malaria Journal 2006 5:118

    Content type: Research

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  25. The African Heads of State meeting in Abuja, Nigeria on Roll Back Malaria adopted effective treatment of malaria nearer the home as one of the strategies for malaria control in Africa. A potentially effective ...

    Authors: Obinna Onwujekwe, Nkem Dike, Juliana Ojukwu, Benjamin Uzochukwu, Nkoli Ezumah, Elvis Shu and Paul Okonkwo

    Citation: Malaria Journal 2006 5:117

    Content type: Research

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  26. The mechanisms leading to death and functional impairments due to cerebral malaria (CM) are yet not fully understood. Most of the knowledge about the pathomechanisms of CM originates from studies in animal mod...

    Authors: Peter Lackner, Ronny Beer, Raimund Helbok, Gregor Broessner, Klaus Engelhardt, Christian Brenneis, Erich Schmutzhard and Kristian Pfaller

    Citation: Malaria Journal 2006 5:116

    Content type: Research

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  27. As Anopheles funestus is one of the principal Afro-tropical malaria vectors, a more complete understanding of its population structure is desirable. In West and Central Africa, An. funestus population structure i...

    Authors: Andrew P Michel, Olga Grushko, Wamdaogo M Guelbeogo, N'Fale Sagnon, Carlo Costantini and Nora J Besansky

    Citation: Malaria Journal 2006 5:115

    Content type: Research

    Published on:

  28. The survivorship and distribution of Anopheles arabiensis larvae and pupae was examined in a rice agro-ecosystem in Mwea Irrigation Scheme, central Kenya, from August 2005 to April 2006, prior to implementation o...

    Authors: Joseph M Mwangangi, Ephantus J Muturi, Josephat Shililu, Simon M Muriu, Benjamin Jacob, Ephantus W Kabiru, Charles M Mbogo, John Githure and Robert Novak

    Citation: Malaria Journal 2006 5:114

    Content type: Research

    Published on:

  29. Presented here are the results of a comparative trial on the efficacy of three artemisinin-based combinations conducted from May to October 2004, in Pool Province, Republic of Congo.

    Authors: Ingrid van den Broek, Christa Kitz, Sarwatt Al Attas, François Libama, Manica Balasegaram and Jean-Paul Guthmann

    Citation: Malaria Journal 2006 5:113

    Content type: Research

    Published on:

  30. Atovaquone is part of the antimalarial drug combination atovaquone-proguanil (Malarone®) and inhibits the cytochrome bc1 complex of the electron transport chain in Plasmodium spp. Molecular modelling showed that ...

    Authors: Tamirat Gebru, Asrat Hailu, Peter G Kremsner, Jürgen FJ Kun and Martin P Grobusch

    Citation: Malaria Journal 2006 5:112

    Content type: Research

    Published on:

  31. Ethnographic studies from East Africa suggest that cerebral malaria and anaemia are not classified in local knowledge as malaria complications, but as illnesses in their own right. Cerebral malaria 'degedege' has...

    Authors: Frank M Ringsted, Ib C Bygbjerg and Helle Samuelsen

    Citation: Malaria Journal 2006 5:111

    Content type: Research

    Published on:

  32. The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the nece...

    Authors: Lyn-Marie Birkholtz, Olivier Bastien, Gordon Wells, Delphine Grando, Fourie Joubert, Vinod Kasam, Marc Zimmermann, Philippe Ortet, Nicolas Jacq, Nadia Saïdani, Sylvaine Roy, Martin Hofmann-Apitius, Vincent Breton, Abraham I Louw and Eric Maréchal

    Citation: Malaria Journal 2006 5:110

    Content type: Review

    Published on:

  33. Malaria control strategies emphasize the need for prompt and effective treatment of malaria episodes. To increase treatment efficacy, Tanzania changed its first-line treatment from chloroquine to sulphadoxine-...

    Authors: Manuel W Hetzel, June J Msechu, Catherine Goodman, Christian Lengeler, Brigit Obrist, S Patrick Kachur, Ahmed Makemba, Rose Nathan, Alexander Schulze and Hassan Mshinda

    Citation: Malaria Journal 2006 5:109

    Content type: Research

    Published on:

  34. Chloroquine (CQ) or sulfadoxine-pyrimethamine (SP) monotherapy for Plasmodium falciparum often leads to therapeutic failure in Indonesia. Combining CQ with other drugs, like SP, may provide an affordable, availab...

    Authors: Edith R Lederman, Jason D Maguire, Iwa W Sumawinata, Krisin Chand, Iqbal Elyazar, Lusi Estiana, Priyanto Sismadi, Michael J Bangs and J Kevin Baird

    Citation: Malaria Journal 2006 5:108

    Content type: Research

    Published on:

  35. Recent resurgence of malaria in the highlands of Western Kenya has called for a more comprehensive understanding of the previously neglected complex highland vector ecology. Besides other drivers of malaria ep...

    Authors: Andrew K Githeko, John M Ayisi, Peter K Odada, Francis K Atieli, Bryson A Ndenga, John I Githure and Guiyun Yan

    Citation: Malaria Journal 2006 5:107

    Content type: Research

    Published on:

  36. Antananarivo, the capital of Madagascar, is located at an altitude of over 1,200 m. The environment at this altitude is not particularly favourable to malaria transmission, but malaria nonetheless remains a ma...

    Authors: Olivier Domarle, Romy Razakandrainibe, Emma Rakotomalala, Laurence Jolivet, Rindra Vatosoa Randremanana, Fanjasoa Rakotomanana, Charles Emile Ramarokoto, Jean-Louis Soares and Frédéric Ariey

    Citation: Malaria Journal 2006 5:106

    Content type: Research

    Published on:

  37. A survey in Kumasi, Ghana found a marked Plasmodium falciparum prevalence difference between two neighbouring communities (Moshie Zongo and Manhyia). The primary objective of this follow-up study was to determine...

    Authors: Lisa A Ronald, Sarah L Kenny, Eveline Klinkenberg, Alex O Akoto, Isaac Boakye, Guy Barnish and Martin J Donnelly

    Citation: Malaria Journal 2006 5:105

    Content type: Research

    Published on:

  38. Thick blood films are routinely used to diagnose Plasmodium falciparum malaria. Here, they were used to diagnose volunteers exposed to experimental malaria challenge.

    Authors: Philip Bejon, Laura Andrews, Angela Hunt-Cooke, Frances Sanderson, Sarah C Gilbert and Adrian VS Hill

    Citation: Malaria Journal 2006 5:104

    Content type: Research

    Published on:

  39. Current detection or screening for malaria infection necessitates drawing blood by fingerprick or venipuncture, which poses risks and limitations for repeated measurement. This study presents PCR detection of Pla...

    Authors: Sungano Mharakurwa, Christopher Simoloka, Philip E Thuma, Clive J Shiff and David J Sullivan

    Citation: Malaria Journal 2006 5:103

    Content type: Methodology

    Published on:

  40. Hyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite...

    Authors: Climent Casals-Pascual, Oscar Kai, Brett Lowe, Mike English, Thomas N Williams, Kathryn Maitland, Charles RCJ Newton, Norbert Peshu and David J Roberts

    Citation: Malaria Journal 2006 5:101

    Content type: Research

    Published on:

  41. Surprisingly little is known about the geographical overlap between malaria and other tropical diseases, including helminth infections. This is despite the potential public health importance of co-infection an...

    Authors: Simon Brooker, Archie CA Clements, Peter J Hotez, Simon I Hay, Andrew J Tatem, Donald AP Bundy and Robert W Snow

    Citation: Malaria Journal 2006 5:99

    Content type: Research

    Published on:

  42. Spatial and longitudinal monitoring of transmission intensity will allow better targeting of malaria interventions. In this study, data on meteorological, demographic, entomological and parasitological data ov...

    Authors: MJAM Oesterholt, JT Bousema, OK Mwerinde, C Harris, P Lushino, A Masokoto, H Mwerinde, FW Mosha and CJ Drakeley

    Citation: Malaria Journal 2006 5:98

    Content type: Research

    Published on:

  43. Malaria is one of the most serious health problems in Kenya. In 2004, the Kenya Medical Research Institute and the US Army Medical Research Unit – Kenya surveyed adults in Samburu, Malindi, and Busia districts...

    Authors: Rodney L Coldren, Trish Prosser, Fredrick Ogolla, Victor O Ofula and Nicholas Adungo

    Citation: Malaria Journal 2006 5:96

    Content type: Research

    Published on:

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