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  1. The variant surface antigen family Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) is an important target for protective immunity and is implicated in the pathology of malaria through its ability to...

    Authors: Thomas Lavstsen, Ali Salanti, Anja TR Jensen, David E Arnot and Thor G Theander
    Citation: Malaria Journal 2003 2:27
  2. The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo. From the X-ray structures a 90° difference in torsion angle between...

    Authors: David C Warhurst, John C Craig, Ipemida S Adagu, David J Meyer and Sylvia Y Lee
    Citation: Malaria Journal 2003 2:26
  3. Malaria is known as tazo or tazomoka in local terminology in Madagascar. Within the context of traditional practice, malaria (and/or malaria symptoms) is commonly treated by decoctions or infusions from bitter...

    Authors: Milijaona Randrianarivelojosia, Valérie T Rasidimanana, Harison Rabarison, Peter K Cheplogoi, Michel Ratsimbason, Dulcie A Mulholland and Philippe Mauclère
    Citation: Malaria Journal 2003 2:25
  4. Despite the extensive polymorphism at the merozoite surface protein-1 (MSP-1) locus of Plasmodium falciparum, that encodes a major repetitive malaria vaccine candidate antigen, identical and nearly identical alle...

    Authors: Erika HE Hoffmann, Paulo EM Ribolla and Marcelo U Ferreira
    Citation: Malaria Journal 2003 2:24
  5. The erythrocyte binding antigen 175 (EBA-175) is a 175 kDa antigen of Plasmodium falciparum and plays a major role in erythrocyte recognition by the parasite. The antigen is also supposed to be partly responsible...

    Authors: Sabine Dittrich, Babett Schwöbel, Sabine Jordan, Vienxay Vanisaveth, Phetsouvanh Rattanaxay, Eva M Christophel, Samlane Phompida and Tomas Jelinek
    Citation: Malaria Journal 2003 2:23
  6. Despite a relatively good national case reporting system in Sri Lanka, detailed maps of malaria distribution have not been publicly available.

    Authors: Olivier JT Briët, Dissanayake M Gunawardena, Wim van der Hoek and Felix P Amerasinghe
    Citation: Malaria Journal 2003 2:22
  7. Plasmodium vivax is the most widely distributed human malaria, responsible for 70–80 million clinical cases each year and large socio-economical burdens for countries such as Brazil where it is the most prevalent...

    Authors: Emilio F Merino, Carmen Fernandez-Becerra, Alda MBN Madeira, Ariane L Machado, Alan Durham, Arthur Gruber, Neil Hall and Hernando A del Portillo
    Citation: Malaria Journal 2003 2:21
  8. Although the effects of rainfall on the population dynamics of the malaria vector Anopheles gambiae have been studied in great detail, the effects of dry periods on its survival remain less clear.

    Authors: Constantianus JM Koenraadt, Krijn P Paaijmans, Andrew K Githeko, Bart GJ Knols and Willem Takken
    Citation: Malaria Journal 2003 2:20
  9. The development of an electroporation based transfection method for Plasmodium falciparum has been very successful for the study of some genes but its efficiency remains very low. While alternative approaches hav...

    Authors: Tina S Skinner-Adams, Paula M Lawrie, Paula L Hawthorne, Donald L Gardiner and Katharine R Trenholme
    Citation: Malaria Journal 2003 2:19
  10. In areas where malaria is endemic, pregnancy is associated with increased susceptibility to malaria. It is generally agreed that this risk ends with delivery and decreases with the number of pregnancies. Our s...

    Authors: Marielle K Bouyou-Akotet, Denisa E Ionete-Collard, Modeste Mabika-Manfoumbi, Eric Kendjo, Pierre-Blaise Matsiegui, Elie Mavoungou and Maryvonne Kombila
    Citation: Malaria Journal 2003 2:18
  11. Malaria parasites that carry the DHFR-mutation I164L are not only highly resistant to sulfadoxine-pyrimethamine but also to the new antimalarial drug chlorproguanil-dapsone. The spread of this mutation in Afri...

    Authors: Ole Wichmann, Tomas Jelinek, Gabriele Peyerl-Hoffmann, Nikolai Mühlberger, Martin P Grobusch, Joaquim Gascon, Alberto Matteelli, Christoph Hatz, Hermann Laferl, Marco Schulze, Gerd Burchard, Saraiva da Cunha, Jiøi Beran, Paul McWhinney, Herwig Kollaritsch, Peter Kern…
    Citation: Malaria Journal 2003 2:17
  12. Malaria can be eradicated from islands. To assess the prospects for eradication of malaria from the island of Príncipe in the Gulf of Guinea, we fitted a mathematical model to age-prevalence curves and thus ob...

    Authors: Reto Hagmann, J Derek Charlwood, Vilfrido Gil, Conceição Ferreira, Virgíllo do Rosário and Tom A Smith
    Citation: Malaria Journal 2003 2:15
  13. There is no established biochemical basis for the neurotoxicity of mefloquine. We investigated the possibility that the acute in vitro neurotoxicity of mefloquine might be mediated through a disruptive effect of ...

    Authors: Geoffrey S Dow, Thomas H Hudson, Maryanne Vahey and Michael L Koenig
    Citation: Malaria Journal 2003 2:14
  14. Malaria control programmes utilising indoor residual spraying are only effective if a high coverage of targeted structures is achieved and an insecticide that is effective against the specific mosquito vector ...

    Authors: Marlize Booman, Brian L Sharp, Carrin L Martin, Bonifacio Manjate, Jacobus J la Grange and David N Durrheim
    Citation: Malaria Journal 2003 2:13
  15. Malaria prevalence differs between the two islands that comprise the archipelago of São Tomé and Príncipe. This may be due to differences in the biology of local Anopheles gambiae, the only vector on the islands....

    Authors: J Derek Charlwood, Joao Pinto, Carla A Sousa, Conceicao Ferreira, Vincenso Petrarca and Virgilio do E Rosario
    Citation: Malaria Journal 2003 2:9
  16. The inflammatory nature of falciparum malaria has been acknowledged since increased circulating levels of tumour necrosis factor (TNF) were first measured, but precisely where the mediators downstream from thi...

    Authors: Ian A Clark, Melissa M Awburn, Richard O Whitten, Clive G Harper, N George Liomba, Malcolm E Molyneux and Terrie E Taylor
    Citation: Malaria Journal 2003 2:6
  17. Resistance of Plasmodium falciparum to atovaquone in vitro and in vivo has been associated to mutations in the parasite cytochrome b gene.

    Authors: Babett Schwöbel, Michael Alifrangis, Ali Salanti and Tomas Jelinek
    Citation: Malaria Journal 2003 2:5
  18. There is no known biochemical basis for the adverse neurological events attributed to mefloquine. Identification of genes modulated by toxic agents using microarrays may provide sufficient information to gener...

    Authors: Geoffrey S Dow
    Citation: Malaria Journal 2003 2:4
  19. Anopheles gambiae is the main vector of Plasmodium falciparum in Africa. The mosquito midgut constitutes a barrier that the parasite must cross if it is to develop and be transmitted. Despite the central role of ...

    Authors: GI Prévot, C Laurent-Winter, F Rodhain and C Bourgouin
    Citation: Malaria Journal 2003 2:1
  20. The development and implementation of innovative vector control strategies for malaria control in Africa requires in-depth ecological studies in contained semi-field environments. This particularly applies to ...

    Authors: Bart GJ Knols, Basilio N Njiru, Evan M Mathenge, Wolfgang R Mukabana, John C Beier and Gerry F Killeen
    Citation: Malaria Journal 2002 1:19
  21. Many studies have suggested that variability in the attractiveness of humans to host-seeking mosquitoes is caused by differences in the make-up of body emanations, and olfactory signals in particular. Most inv...

    Authors: Wolfgang R Mukabana, Willem Takken, Richard Coe and Bart GJ Knols
    Citation: Malaria Journal 2002 1:17
  22. Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to c...

    Authors: Nadine Fievet, Germaine Tami, Bertrand Maubert, Marlène Moussa, Ian K Shaw, Michel Cot, Anthony A Holder, Gérard Chaouat and Philippe Deloron
    Citation: Malaria Journal 2002 1:16
  23. Insecticide-treated materials (ITMs) are effective in substantially reducing the burden of malaria and other vector-borne diseases; but how can high coverage rates of ITMs be achieved and maintained? In south ...

    Authors: Axel Kroeger, Ana Aviñna, José Ordoñnez-Gonzalez and Celia Escandon
    Citation: Malaria Journal 2002 1:15
  24. Sequential analysis enables repeated statistical analyses to be performed throughout a trial recruitment period, while maintaining a pre-specified power and type I error. Thus the trial can be stopped as soon ...

    Authors: Stéphane Ranque, Sékéné Badiaga, Jean Delmont and Philippe Brouqui
    Citation: Malaria Journal 2002 1:13
  25. The increasing levels of Plasmodium falciparum resistance to chloroquine (CQ) in Thailand have led to the use of alternative antimalarials, which are at present also becoming ineffective. In this context, any str...

    Authors: Dinora Lopes, Kanchana Rungsihirunrat, Fátima Nogueira, Aree Seugorn, José Pedro Gil, Virgilio E do Rosário and Pedro Cravo
    Citation: Malaria Journal 2002 1:12
  26. Results from numerous studies point convincingly to correlations between mutations at selected genes and phenotypic resistance to antimalarials in Plasmodium falciparum isolates. In order to move molecular assays...

    Authors: Tomas Jelinek, Gabriele Peyerl-Hoffmann, Nikolai Mühlberger, Ole Wichmann, Michael Wilhelm, Nadja Schmider, Martin P Grobusch, Frank von Sonnenburg, Joaquim Gascon, Hermann Laferl, Christoph Hatz, Michael Alifrangis, Gerd Burchard, Paul McWhinney, Marco Schulze, Herwig Kollaritsch…
    Citation: Malaria Journal 2002 1:11
  27. Plasmodium-refractory mosquitoes are being rapidly developed for malaria control but will only succeed if they can successfully compete for mates when released into the wild. Pre-copulatory behavioural traits mai...

    Authors: FM Okanda, A Dao, BN Njiru, J Arija, HA Akelo, Y Touré, A Odulaja, JC Beier, JI Githure, G Yan, LC Gouagna, BGJ Knols and GF Killeen
    Citation: Malaria Journal 2002 1:10
  28. Much communicable disease control research has had little impact on local control programme policy and practice for want of an operational component. The operational research model – the systematic search for ...

    Authors: David N Durrheim, Richard Speare and Anthony D Harries
    Citation: Malaria Journal 2002 1:9
  29. Based on sensitivity analysis of the MacDonald-Ross model, it has long been argued that the best way to reduce malaria transmission is to target adult female mosquitoes with insecticides that can reduce the lo...

    Authors: Gerry F Killeen, Ulrike Fillinger and Bart GJ Knols
    Citation: Malaria Journal 2002 1:8
  30. Plasmodium falciparum erythrocyte membrane protein-1, a variant antigen of the malaria parasite, is potentially a target for the immune response. It would be important to determine whether there are CD4 T cells t...

    Authors: Latifu A Sanni, Catherine EM Allsopp, Lieke Reubsaet, Ambaliou Sanni, Chris Newbold, Virander S Chauhan and Jean Langhorne
    Citation: Malaria Journal 2002 1:7
  31. In host erythrocytes, the malaria parasite must contend with ion and drug transport across three membranes; its own plasma membrane, the parasitophorous membrane and the host plasma membrane. Isolation of pure...

    Authors: Laurence M Elandalloussi and Pete J Smith
    Citation: Malaria Journal 2002 1:6
  32. Reversible protein phosphorylation is relatively unexplored in the intracellular protozoa of the Apicomplexa family that includes the genus Plasmodium, to which belong the causative agents of malaria. Members of ...

    Authors: Rajinder Kumar, Brian Adams, Anja Oldenburg, Alla Musiyenko and Sailen Barik
    Citation: Malaria Journal 2002 1:5
  33. We report the first in vitro and genetic confirmation of Malarone® (GlaxoSmithKline; atovaquone and proguanil hydrochloride) resistance in Plasmodium falciparum acquired in Africa. On presenting with malaria two ...

    Authors: Quinton L Fivelman, Geoffrey A Butcher, Ipemida S Adagu, David C Warhurst and Geoffrey Pasvol
    Citation: Malaria Journal 2002 1:1

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