Skip to main content
Download PDF

Volume 9 Supplement 2

Parasite to Prevention: Advances in the understanding of malaria

Evaluation of in vivo Antiplasmodial Activities of extracts of Morinda morindiodes (Bak.) in the treatment of malaria in Ogun State

Malaria Journal volume 9, Article number: P51 (2010) Cite this article

In vivo study of various plant parts extracts of Morinda morindiodes (Bak.) was conducted to evaluate their antiplasmodial properties and effects on the liver using chloroquine sensitive Plasmodium berghei in mice. Water extract of the root was observed to significantly reduce parasitaemia (70%, P<0.05) compared to the activities of other plant parts and the untreated control. A mean survival time of 19 days observed in the root extract supported its antiplasmodial activities compared with other plant parts. The antiplasmodial activities of the plant extracts when administered twice daily were not significantly different (P > 0.05) compared with those treated once daily. The chemosuppression produced by the extracts were significantly different compared to untreated control. Liver function tests (LFT) of uninfected mice administered with the plant extracts showed that extracts of the leaf and stem in 'fermented maize starch extract' altered the function of the liver significantly compared to normal mice. This study shows that Morinda morindiodes possess antimalarial properties and the root may be used as a prophylaxis where western medicine is not easily accessible and affordable. Tables 1, 2, 3, 4

Table 1 Chemosuppression and survival time of P. berghei infected mice treated orally with Morinda morindiodes extracts at a dose of 100mg/kg body weight once a day for 5 days
Full size table
Table 2 Chemosuppression and survival time of P. berghei infected mice treated orally with Morinda morindiodes extracts at a dose of 100mg/kg body weight twice a day for 5 days
Full size table
Table 3 Comparison between the liver function tests in mice treated with extracts and control group (untreated)
Full size table
Table 4 Phytochemical analysis of the various plant parts of Morinda morindiodes
Full size table

References

  1. Abosi AO, Raseroka BH: In vivo antimalarial activity of Vernonia amygdalina. British Journal of Biomedical Science. 2003, 60 (22): 89-91.

    PubMed  Google Scholar 

  2. Ajaiyeoba EO, Oladepo O, Fawole OI, Bolaji OM, Akinboye DO, Ogundahunsi OAT, Falade CO, Gbotosho GO, Itiola OA, Happi TC, Ebong OO, Ononimu IM, Osowole OS, Oduola OO, Ashidi JS, Oduola AMJ: Cultural categorization of febril illnesses in correlation with herbal remedies used for treatment in Southwestern Nigeria. Journal of Ethnopharmacology. 2003, 85: 179-185. 10.1016/S0378-8741(02)00357-4.

    Article  CAS  PubMed  Google Scholar 

  3. Andrade-Neto VF, Brandao MG, Stehman JR, Oliveira LA, Krettli AU: Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil. Journal of Ethnopharmacology. 2003, 87: 253-256. 10.1016/S0378-8741(03)00141-7.

    Article  CAS  PubMed  Google Scholar 

  4. Harborne JB: Phytochemical Methods. A Guide to Modern Techniques to Plant Analysis. 1987, London, Chapman and Hall, 56-79. 3rd edn

    Google Scholar 

  5. Idowu OA, Soniran OT, Ajana O, Aworinde DO: Ethnobotanical Survey of antimalarial plants used in Ogun State, Southwest Nigeria. African Journal of Pharmacy and Pharmacology. 2010, 4: 55-60.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Sciences, University of Agriculture, Abeokuta

    Soniran O Temidayo, Idowu Olufunmilayo, Idowu A Babatunde & Ajana Olusegun

Authors
  1. Soniran O Temidayo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Idowu Olufunmilayo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Idowu A Babatunde
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ajana Olusegun
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and Permissions

About this article

Cite this article

Temidayo, S.O., Olufunmilayo, I., Babatunde, I.A. et al. Evaluation of in vivo Antiplasmodial Activities of extracts of Morinda morindiodes (Bak.) in the treatment of malaria in Ogun State. Malar J 9 (Suppl 2), P51 (2010). https://doi.org/10.1186/1475-2875-9-S2-P51

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/1475-2875-9-S2-P51

Keywords

  • Starch
  • Malaria
  • Untreated Control
  • Plant Extract
  • Plasmodium

Malaria Journal

ISSN: 1475-2875

Contact us