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Evaluation of in vivo Antiplasmodial Activities of extracts of Morinda morindiodes (Bak.) in the treatment of malaria in Ogun State

In vivo study of various plant parts extracts of Morinda morindiodes (Bak.) was conducted to evaluate their antiplasmodial properties and effects on the liver using chloroquine sensitive Plasmodium berghei in mice. Water extract of the root was observed to significantly reduce parasitaemia (70%, P<0.05) compared to the activities of other plant parts and the untreated control. A mean survival time of 19 days observed in the root extract supported its antiplasmodial activities compared with other plant parts. The antiplasmodial activities of the plant extracts when administered twice daily were not significantly different (P > 0.05) compared with those treated once daily. The chemosuppression produced by the extracts were significantly different compared to untreated control. Liver function tests (LFT) of uninfected mice administered with the plant extracts showed that extracts of the leaf and stem in 'fermented maize starch extract' altered the function of the liver significantly compared to normal mice. This study shows that Morinda morindiodes possess antimalarial properties and the root may be used as a prophylaxis where western medicine is not easily accessible and affordable. Tables 1, 2, 3, 4

Table 1 Chemosuppression and survival time of P. berghei infected mice treated orally with Morinda morindiodes extracts at a dose of 100mg/kg body weight once a day for 5 days
Table 2 Chemosuppression and survival time of P. berghei infected mice treated orally with Morinda morindiodes extracts at a dose of 100mg/kg body weight twice a day for 5 days
Table 3 Comparison between the liver function tests in mice treated with extracts and control group (untreated)
Table 4 Phytochemical analysis of the various plant parts of Morinda morindiodes

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Temidayo, S.O., Olufunmilayo, I., Babatunde, I.A. et al. Evaluation of in vivo Antiplasmodial Activities of extracts of Morinda morindiodes (Bak.) in the treatment of malaria in Ogun State. Malar J 9, P51 (2010). https://doi.org/10.1186/1475-2875-9-S2-P51

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  • DOI: https://doi.org/10.1186/1475-2875-9-S2-P51

Keywords

  • Starch
  • Malaria
  • Untreated Control
  • Plant Extract
  • Plasmodium