- Poster presentations
- Open Access
Evaluation of in vivo Antiplasmodial Activities of extracts of Morinda morindiodes (Bak.) in the treatment of malaria in Ogun State
Malaria Journalvolume 9, Article number: P51 (2010)
In vivo study of various plant parts extracts of Morinda morindiodes (Bak.) was conducted to evaluate their antiplasmodial properties and effects on the liver using chloroquine sensitive Plasmodium berghei in mice. Water extract of the root was observed to significantly reduce parasitaemia (70%, P<0.05) compared to the activities of other plant parts and the untreated control. A mean survival time of 19 days observed in the root extract supported its antiplasmodial activities compared with other plant parts. The antiplasmodial activities of the plant extracts when administered twice daily were not significantly different (P > 0.05) compared with those treated once daily. The chemosuppression produced by the extracts were significantly different compared to untreated control. Liver function tests (LFT) of uninfected mice administered with the plant extracts showed that extracts of the leaf and stem in 'fermented maize starch extract' altered the function of the liver significantly compared to normal mice. This study shows that Morinda morindiodes possess antimalarial properties and the root may be used as a prophylaxis where western medicine is not easily accessible and affordable. Tables 1, 2, 3, 4
Abosi AO, Raseroka BH: In vivo antimalarial activity of Vernonia amygdalina. British Journal of Biomedical Science. 2003, 60 (22): 89-91.
Ajaiyeoba EO, Oladepo O, Fawole OI, Bolaji OM, Akinboye DO, Ogundahunsi OAT, Falade CO, Gbotosho GO, Itiola OA, Happi TC, Ebong OO, Ononimu IM, Osowole OS, Oduola OO, Ashidi JS, Oduola AMJ: Cultural categorization of febril illnesses in correlation with herbal remedies used for treatment in Southwestern Nigeria. Journal of Ethnopharmacology. 2003, 85: 179-185. 10.1016/S0378-8741(02)00357-4.
Andrade-Neto VF, Brandao MG, Stehman JR, Oliveira LA, Krettli AU: Antimalarial activity of Cinchona-like plants used to treat fever and malaria in Brazil. Journal of Ethnopharmacology. 2003, 87: 253-256. 10.1016/S0378-8741(03)00141-7.
Harborne JB: Phytochemical Methods. A Guide to Modern Techniques to Plant Analysis. 1987, London, Chapman and Hall, 56-79. 3rd edn
Idowu OA, Soniran OT, Ajana O, Aworinde DO: Ethnobotanical Survey of antimalarial plants used in Ogun State, Southwest Nigeria. African Journal of Pharmacy and Pharmacology. 2010, 4: 55-60.