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  1. Malaria epidemics cause substantial morbidity and mortality in highland areas of Africa. The costs of detecting and controlling these epidemics have not been explored adequately in the past. This study present...

    Authors: Dirk H Mueller, Tarekegn A Abeku, Michael Okia, Beth Rapuoda and Jonathan Cox
    Citation: Malaria Journal 2009 8:17
  2. While the protective effects of sickle cell trait (HbAS) against severe malaria and the resulting survival advantage are well known, the impact on the physical development in young children remains unclear. Th...

    Authors: Benno Kreuels, Stephan Ehrhardt, Christina Kreuzberg, Samuel Adjei, Robin Kobbe, Gerd D Burchard, Christa Ehmen, Matilda Ayim, Ohene Adjei and Jürgen May
    Citation: Malaria Journal 2009 8:16
  3. An increasing number of malaria-endemic African countries are rapidly scaling up malaria prevention and treatment. To have an initial estimate of the impact of these efforts, time trends in health facility rec...

    Authors: Mac Otten, Maru Aregawi, Wilson Were, Corine Karema, Ambachew Medin, Worku Bekele, Daddi Jima, Khoti Gausi, Ryuichi Komatsu, Eline Korenromp, Daniel Low-Beer and Mark Grabowsky
    Citation: Malaria Journal 2009 8:14
  4. Despite low endemicity, malaria remains a major health problem in urban areas where a high proportion of fevers are presumptively treated using anti-malarial drugs. Low acquired malaria immunity, behaviour of ...

    Authors: Meili Baragatti, Florence Fournet, Marie-Claire Henry, Serge Assi, Herman Ouedraogo, Christophe Rogier and Gérard Salem
    Citation: Malaria Journal 2009 8:13
  5. Malaria is one of the most important infectious diseases in the world. Although most cases are found distributed in the tropical regions of Africa, Asia, Central and South Americas, there is in Europe a signif...

    Authors: Marianna Marangi, Rocco Di Tullio, Pètra F Mens, Domenico Martinelli, Vincenzina Fazio, Gioacchino Angarano, Henk DFH Schallig, Annunziata Giangaspero and Gaetano Scotto
    Citation: Malaria Journal 2009 8:12
  6. The combination of artesunate and mefloquine was introduced as the national first-line treatment for Plasmodium falciparum malaria in Cambodia in 2000. However, recent clinical trials performed at the Thai-Cambod...

    Authors: Pharath Lim, Alisa P Alker, Nimol Khim, Naman K Shah, Sandra Incardona, Socheat Doung, Poravuth Yi, Denis Mey Bouth, Christiane Bouchier, Odile Mercereau Puijalon, Steven R Meshnick, Chansuda Wongsrichanalai, Thierry Fandeur, Jacques Le Bras, Pascal Ringwald and Frédéric Ariey
    Citation: Malaria Journal 2009 8:11
  7. Resistance to anti-malarial drugs hampers control efforts and increases the risk of morbidity and mortality from malaria. The efficacy of standard therapies for uncomplicated Plasmodium falciparum and Plasmodium ...

    Authors: William O Rogers, Rithy Sem, Thong Tero, Pheaktra Chim, Pharath Lim, Sinuon Muth, Duong Socheat, Frédéric Ariey and Chansuda Wongsrichanalai
    Citation: Malaria Journal 2009 8:10
  8. Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to ach...

    Authors: Alfredo Mayor, Elisa Serra-Casas, Azucena Bardají, Sergi Sanz, Laura Puyol, Pau Cisteró, Betuel Sigauque, Inacio Mandomando, John J Aponte, Pedro L Alonso and Clara Menéndez
    Citation: Malaria Journal 2009 8:9
  9. Accurate information about the burden of malaria infection at the district or provincial level is required both to plan and assess local malaria control efforts. Although many studies of malaria epidemiology, ...

    Authors: Din Syafruddin, Krisin, Puji Asih, Sekartuti, Rita M Dewi, Farah Coutrier, Ismail E Rozy, Augustina I Susanti, Iqbal RF Elyazar, Awalludin Sutamihardja, Agus Rahmat, Michael Kinzer and William O Rogers
    Citation: Malaria Journal 2009 8:8
  10. Because of the emergence of chloroquine resistance in Mali, artemether-lumefantrine (AL) or artesunate-amodiaquine (AS+AQ) are recommended as first-line therapy for uncomplicated malaria, but have not been ava...

    Authors: Kassoum Kayentao, Hamma Maiga, Robert D Newman, Meredith L McMorrow, Annett Hoppe, Oumar Yattara, Hamidou Traore, Younoussou Kone, Etienne A Guirou, Renion Saye, Boubacar Traore, Abdoulaye Djimde and Ogobara K Doumbo
    Citation: Malaria Journal 2009 8:5
  11. The understanding of the epidemiology of severe malaria in African children remains incomplete across the spectrum of Plasmodium falciparum transmission intensities through which communities might expect to trans...

    Authors: Emelda A Okiro, Abdullah Al-Taiar, Hugh Reyburn, Richard Idro, James A Berkley and Robert W Snow
    Citation: Malaria Journal 2009 8:4
  12. Despite a successful control programme, malaria has not completely disappeared in Vietnam; it remains endemic in remote areas of central Vietnam, where standard control activities seem to be less effective. Th...

    Authors: Ngo Duc Thang, Annette Erhart, Le Xuan Hung, Le Khanh Thuan, Nguyen Xuan Xa, Nguyen Ngoc Thanh, Pham Van Ky, Marc Coosemans, Nico Speybroeck and Umberto D'Alessandro
    Citation: Malaria Journal 2009 8:3
  13. Change of first-line treatment of uncomplicated malaria to artemisinin-combination therapy (ACT) is widespread in Africa. To expand knowledge of safety profiles of ACT, pharmacovigilance activities are include...

    Authors: Alexander NO Dodoo, Carole Fogg, Alex Asiimwe, Edmund T Nartey, Augustina Kodua, Ofori Tenkorang and David Ofori-Adjei
    Citation: Malaria Journal 2009 8:2
  14. The ATP-binding cassette (ABC) superfamily is one of the largest evolutionarily conserved families of proteins. ABC proteins play key roles in cellular detoxification of endobiotics and xenobiotics. Overexpres...

    Authors: María González-Pons, Ada C Szeto, Ricardo González-Méndez and Adelfa E Serrano
    Citation: Malaria Journal 2009 8:1
  15. Artemether/lumefantrine (AL) has been adopted as the treatment of choice for uncomplicated malaria in Kenya and other countries in the region. Six-dose artemether/lumefantrine tablets are highly effective and ...

    Authors: Elizabeth A Juma, Charles O Obonyo, Willis S Akhwale and Bernhards R Ogutu
    Citation: Malaria Journal 2008 7:262
  16. Numerous trials have demonstrated high efficacy and safety of artemisinin-based combination therapy (ACT) under supervised treatment. In contrast, effectiveness studies comparing different types of ACT applied...

    Authors: Robin Kobbe, Philipp Klein, Samuel Adjei, Solomon Amemasor, William Nana Thompson, Hanna Heidemann, Maja V Nielsen, Julia Vohwinkel, Benedikt Hogan, Benno Kreuels, Martina Bührlen, Wibke Loag, Daniel Ansong and Jürgen May
    Citation: Malaria Journal 2008 7:261
  17. Delivery of two doses of intermittent preventive treatment of malaria during pregnancy (IPTp) is a key strategy to reduce the burden of malaria in pregnancy in sub-Saharan Africa. However, different settings h...

    Authors: Tanya Marchant, Rose Nathan, Caroline Jones, Hadji Mponda, Jane Bruce, Yovitha Sedekia, Joanna Schellenberg, Hassan Mshinda and Kara Hanson
    Citation: Malaria Journal 2008 7:260
  18. There are limited data on the evolution of the leukocyte and platelet counts in malaria patients.

    Authors: Walter RJ Taylor, Hendra Widjaja, Hasan Basri, Colin Ohrt, Taufik Taufik, Emiliana Tjitra, Samuel Baso, David Fryauff, Stephen L Hoffman and Thomas L Richie
    Citation: Malaria Journal 2008 7:259
  19. Five large insecticide-treated net (ITN) programmes and two indoor residual spraying (IRS) programmes were compared using a standardized costing methodology.

    Authors: Joshua O Yukich, Christian Lengeler, Fabrizio Tediosi, Nick Brown, Jo-Ann Mulligan, Des Chavasse, Warren Stevens, John Justino, Lesong Conteh, Rajendra Maharaj, Marcy Erskine, Dirk H Mueller, Virginia Wiseman, Tewolde Ghebremeskel, Mehari Zerom, Catherine Goodman…
    Citation: Malaria Journal 2008 7:258
  20. Severe anaemia requiring emergency blood transfusion is a common complication of malaria in children. To ensure access for urgent blood transfusion, the World Health Organization has developed clear guidelines...

    Authors: Samuel O Akech, Oliver Hassall, Allan Pamba, Richard Idro, Thomas N Williams, Charles RJC Newton and Kathryn Maitland
    Citation: Malaria Journal 2008 7:256
  21. In the high malaria-transmission settings of sub-Saharan Africa, malaria in pregnancy is an important cause of maternal, perinatal and neonatal morbidity. Intermittent preventive treatment of malaria in pregna...

    Authors: R Matthew Chico, Rudiger Pittrof, Brian Greenwood and Daniel Chandramohan
    Citation: Malaria Journal 2008 7:255
  22. Infection with the protozoan parasite Plasmodium is the cause of malaria. Plasmodium infects host erythrocytes causing the pathology of the disease. Plasmodium-infected erythrocytes can modulate the maturation of...

    Authors: Jamie M Orengo, Kurt A Wong, Carlos Ocaña-Morgner and Ana Rodriguez
    Citation: Malaria Journal 2008 7:254
  23. Molecular mechanisms involved in the pathogenesis of severe Plasmodium falciparum malaria (SM), are not yet fully understood. Both endothelin-1 (ET-1) and C-type natriuretic peptide (CNP) are produced by vascular...

    Authors: Anelia Dietmann, Peter Lackner, Raimund Helbok, Katharina Spora, Saadou Issifou, Bertrand Lell, Markus Reindl, Peter G Kremsner and Erich Schmutzhard
    Citation: Malaria Journal 2008 7:253
  24. Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating formation of reactive oxygen intermediates (ROI) which play an important role in host defense and auto...

    Authors: Bernhard Greve, Peter Hoffmann, Reinhard Vonthein, Jürgen Kun, Bertrand Lell, Marcin P Mycko, Krysztof W Selmaj, Klaus Berger, Robert Weissert and Peter G Kremsner
    Citation: Malaria Journal 2008 7:251
  25. Malaria eradication raises many economic, financial and institutional challenges. This paper reviews these challenges, drawing on evidence from previous efforts to eradicate malaria, with a special focus on re...

    Authors: Anne Mills, Yoel Lubell and Kara Hanson
    Citation: Malaria Journal 2008 7(Suppl 1):S11

    This article is part of a Supplement: Volume 7 Supplement 1

  26. Research on malaria vaccines is currently directed primarily towards the development of vaccines that prevent clinical malaria. Malaria elimination, now being considered seriously in some epidemiological situa...

    Authors: Geoffrey A Targett and Brian M Greenwood
    Citation: Malaria Journal 2008 7(Suppl 1):S10

    This article is part of a Supplement: Volume 7 Supplement 1

  27. More attention is being focused on malaria today than any time since the world's last efforts to achieve eradication over 40 years ago. The global community is now discussing strategies aimed at dramatically r...

    Authors: Mary R Galinski and John W Barnwell
    Citation: Malaria Journal 2008 7(Suppl 1):S9

    This article is part of a Supplement: Volume 7 Supplement 1

  28. Following a long period when the effectiveness of existing mono-therapies for antimalarials was steadily declining with no clear alternative, most malaria-endemic countries in Africa and Asia have adopted arte...

    Authors: Christopher JM Whitty, Clare Chandler, Evelyn Ansah, Toby Leslie and Sarah G Staedke
    Citation: Malaria Journal 2008 7(Suppl 1):S7

    This article is part of a Supplement: Volume 7 Supplement 1

  29. Monitoring and evaluation of malaria control in pregnancy is essential for assessing the efficacy and effectiveness of health interventions aimed at reducing the major burden of this disease on women living in...

    Authors: Bernard J Brabin, Marian Warsame, Ulrika Uddenfeldt-Wort, Stephanie Dellicour, Jenny Hill and Sabine Gies
    Citation: Malaria Journal 2008 7(Suppl 1):S6

    This article is part of a Supplement: Volume 7 Supplement 1

  30. Diagnostic testing for malaria has for many years been eschewed, lest it be an obstacle to the delivery of rapid, life-saving treatment. The approach of treating malaria without confirmatory testing has been r...

    Authors: Mark D Perkins and David R Bell
    Citation: Malaria Journal 2008 7(Suppl 1):S5

    This article is part of a Supplement: Volume 7 Supplement 1

  31. Integrated vector management (IVM) is defined as "a rational decision-making process for the optimal use of resources for vector control" and includes five key elements: 1) evidence-based decision-making, 2) i...

    Authors: John C Beier, Joseph Keating, John I Githure, Michael B Macdonald, Daniel E Impoinvil and Robert J Novak
    Citation: Malaria Journal 2008 7(Suppl 1):S4

    This article is part of a Supplement: Volume 7 Supplement 1

  32. Speculations on the potential impact of climate change on human health frequently focus on malaria. Predictions are common that in the coming decades, tens – even hundreds – of millions more cases will occur i...

    Authors: Paul Reiter
    Citation: Malaria Journal 2008 7(Suppl 1):S3

    This article is part of a Supplement: Volume 7 Supplement 1

  33. Host adhesion molecules play a significant role in the pathogenesis of Plasmodium falciparum malaria and changes in their structure or levels in individuals can influence the outcome of infection. The aim of this...

    Authors: Swapnil Sinha, Tabish Qidwai, Kanika Kanchan, Prerna Anand, Ganga N Jha, Sudhanshu S Pati, Sanjib Mohanty, Saroj K Mishra, Prajesh K Tyagi, Surya K Sharma, Vimala Venkatesh and Saman Habib
    Citation: Malaria Journal 2008 7:250
  34. The aim of this study was to identify and compare factors associated with Plasmodium falciparum gametocyte carriage in three regions of differing malaria endemicity.

    Authors: Kasia Stepniewska, Ric N Price, Colin J Sutherland, Chris J Drakeley, Lorenz von Seidlein, Francois Nosten and Nicholas J White
    Citation: Malaria Journal 2008 7:249
  35. Malaria parasite infectivity to mosquitoes has been measured in a variety of ways and setting, includind direct feeds of and/or membrane feeding blood collected from randomly selected or gametocytemic voluntee...

    Authors: Mouctar Diallo, Abdoulaye M Touré, Sekou F Traoré, Oumou Niaré, Lalla Kassambara, Awa Konaré, Mamadou Coulibaly, Magaran Bagayogo, John C Beier, Richard K Sakai, Yéya T Touré and Ogobara K Doumbo
    Citation: Malaria Journal 2008 7:248
  36. Insecticide resistance can present a major obstacle to malaria control programmes. Following the recent detection of DDT resistance in Anopheles arabiensis in Gokwe, Zimbabwe, the underlying resistance mechanisms...

    Authors: Givemore Munhenga, Hieronymo T Masendu, Basil D Brooke, Richard H Hunt and Lizette K Koekemoer
    Citation: Malaria Journal 2008 7:247
  37. The six-dose regimen of artemether-lumefantrine (AL) is now considered the gold standard for the treatment of uncomplicated Plasmodium falciparum malaria. There are few reports evaluating co-artemether in very yo...

    Authors: Catherine O Falade, Oluwatoyin O Ogunkunle, Hannah O Dada-Adegbola, Adegoke G Falade, Patricia Ibarra de Palacios, Philip Hunt, Mailis Virtanen, Ayoade M Oduola and Lateef A Salako
    Citation: Malaria Journal 2008 7:246
  38. A fixed-dose combination of artemether-lumefantrine (AL, Coartem®) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium falcipar...

    Authors: Zulfiqarali G Premji, Salim Abdulla, Bernhards Ogutu, Alice Ndong, Catherine O Falade, Issaka Sagara, Nathan Mulure, Obiyo Nwaiwu and Gilbert Kokwaro
    Citation: Malaria Journal 2008 7:244
  39. Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled tr...

    Authors: Bertrand Graz, Moussa Dicko, Merlin L Willcox, Bernard Lambert, Jacques Falquet, Mathieu Forster, Sergio Giani, Chiaka Diakite, Eugène M Dembele, Drissa Diallo and Hubert Barennes
    Citation: Malaria Journal 2008 7:242

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