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  1. Sulphadoxine/sulphalene-pyrimethamine (SP) was adopted in Kenya as first line therapeutic for uncomplicated malaria in 1998. By the second half of 2003, there was convincing evidence that SP was failing and ha...

    Authors: Abdinasir A Amin, Dejan Zurovac, Beth B Kangwana, Joanne Greenfield, Dorothy N Otieno, Willis S Akhwale and Robert W Snow
    Citation: Malaria Journal 2007 6:72
  2. Because of the belief that Nairobi is a low risk zone for malaria, little empirical data exists on malaria risk in the area. The aim of this study was to explore the risk of perceived malaria and some associat...

    Authors: Yazoumé Yé, Elizabeth Kimani-Murage, John Kebaso and Frederick Mugisha
    Citation: Malaria Journal 2007 6:71
  3. The study investigated the pharmacokinetics of fosmidomycin when given alone and in combination with clindamycin in patients with acute uncomplicated falciparum malaria.

    Authors: Kesara Na-Bangchang, Ronnatrai Ruengweerayut, Juntra Karbwang, Anurak Chauemung and David Hutchinson
    Citation: Malaria Journal 2007 6:70
  4. The overlap in geographical distribution of Plasmodium falciparum malaria and endemic Burkitt's lymphoma (eBL) – an aggressive Epstein-Barr virus (EBV)-associated B-cell tumour occurring almost exclusively in the...

    Authors: Godfred Futagbi, Jennifer E Welbeck, John Kweku A Tetteh, Lars Hviid and Bartholomew D Akanmori
    Citation: Malaria Journal 2007 6:69
  5. The acceptability and efficacy of a new kit with a new formulation of quinine alkaloids designed for the intra-rectal administration in the treatment of non-per os malaria was assessed in the peripheral health...

    Authors: Mahamadou A Thera, Falaye Keita, Mahamadou S Sissoko, Oumar B Traoré, Drissa Coulibaly, Massambou Sacko, Valerie Lameyre, Jean Pascal Ducret and Ogobara Doumbo
    Citation: Malaria Journal 2007 6:68
  6. Anaemic status is determined by haemoglobin using the HemoCue system or haematocrit measurements, and a threefold conversion is commonly used to equate the two measures (haemoglobin = haematocrit/3). The valid...

    Authors: Ilona A Carneiro, Chris J Drakeley, Seth Owusu-Agyei, Bruno Mmbando and Daniel Chandramohan
    Citation: Malaria Journal 2007 6:67
  7. Sensitive detection of parasite surface antigens expressed on erythrocyte membranes is necessary to further analyse the molecular pathology of malaria. This study describes a modified biotin labelling/osmotic ...

    Authors: Lisa Sharling, Kordai MP Sowa, Joanne Thompson, Helen M Kyriacou and David E Arnot
    Citation: Malaria Journal 2007 6:66
  8. Data concerning antimalarial combination treatment for uncomplicated malaria in Madagascar are largely lacking. Randomized clinical trial was designed to assess therapeutic efficacies of chloroquine (CQ), amod...

    Authors: Didier Ménard, Nohary Nina Harimanana Andrianina, Zakaherizo Ramiandrasoa, Arthur Randriamanantena, Noéline Rasoarilalao, Martial Jahevitra, Arsène Ratsimbasoa, Luciano Tuseo and Andrianirina Raveloson
    Citation: Malaria Journal 2007 6:65
  9. Paroxysms are recurrent febrile episodes, characteristic of Plasmodium vivax infections, which coincide with the rupture of schizont-infected erythrocytes in the patients' circulation. The present study describes...

    Authors: Nadira Karunaweera, Deepani Wanasekara, Vishvanath Chandrasekharan, Kamini Mendis and Richard Carter
    Citation: Malaria Journal 2007 6:62
  10. Intracellular malaria parasites leave their host erythrocytes to infect neighbouring cells after each cycle of asexual replication. No method is currently available for the direct quantification of parasite re...

    Authors: Svetlana Glushakova, Dan Yin, Nicole Gartner and Joshua Zimmerberg
    Citation: Malaria Journal 2007 6:61
  11. Molecular techniques have facilitated the studies on genetic diversity of Plasmodium species particularly from field isolates collected directly from patients. The msp-1 and msp-2 are highly polymorphic markers a...

    Authors: Hema Joshi, Neena Valecha, Anju Verma, Asha Kaul, Prashant K Mallick, Sneh Shalini, Surendra K Prajapati, Surya K Sharma, Vas Dev, Sukla Biswas, Nutan Nanda, MS Malhotra, Sarala K Subbarao and Aditya P Dash
    Citation: Malaria Journal 2007 6:60
  12. Immune responses to malaria blood stage infection are in general defective, with the need for long-term exposure to the parasite to achieve immunity, and with the development of immunopathology states such as ...

    Authors: Leonardo JM Carvalho, Maria F Ferreira-da-Cruz, Claudio T Daniel-Ribeiro, Marcelo Pelajo-Machado and Henrique L Lenzi
    Citation: Malaria Journal 2007 6:59
  13. An assessment of the accuracy of Paracheck Pf®, a malaria rapid diagnostic test (RDT) detecting histidine rich protein 2 was undertaken amongst children aged 6–59 months in eastern Democratic Republic of Congo.

    Authors: Todd D Swarthout, Helen Counihan, Raphael Kabangwa K Senga and Ingrid van den Broek
    Citation: Malaria Journal 2007 6:58
  14. Global malaria control strategies highlight the need to increase early uptake of effective antimalarials for childhood fevers in endemic settings, based on a presumptive diagnosis of malaria in this age group....

    Authors: Timothy O Abuya, Wilfred Mutemi, Baya Karisa, Sam A Ochola, Greg Fegan and Vicki Marsh
    Citation: Malaria Journal 2007 6:57
  15. The emergence of Anopheles populations capable of withstanding lethal doses of insecticides has weakened the efficacy of most insecticide based strategies of vector control and, has highlighted the need for devel...

    Authors: Rousseau F Djouaka, Adekunle A Bakare, Honore S Bankole, Julien MC MC Doannio, Hortense Kossou and Martin C Akogbeto
    Citation: Malaria Journal 2007 6:56
  16. Nigeria's national standard has recently moved to artemisinin combination treatments for malaria. As clinicians in the private sector are responsible for attending a large proportion of the population ill with...

    Authors: Martin Meremikwu, Uduak Okomo, Chukwuemeka Nwachukwu, Angela Oyo-Ita, John Eke-Njoku, Joseph Okebe, Esu Oyo-Ita and Paul Garner
    Citation: Malaria Journal 2007 6:55
  17. In the last five years, countries have been faced with changing their malaria treatment policy to an artemisinin-based combination therapy (ACT), many with no national data on which to base their decision. Thi...

    Authors: Maryline Bonnet, Cally Roper, Martine Félix, Léonie Coulibaly, Gabriel Mufuta Kankolongo and Jean Paul Guthmann
    Citation: Malaria Journal 2007 6:54
  18. A comprehensive malaria control intervention was initiated in February 2004 on Bioko Island, Equatorial Guinea. This manuscript reports on the continuous entomological monitoring of the indoor residual spray (...

    Authors: Brian L Sharp, Frances C Ridl, Dayanandan Govender, Jaime Kuklinski and Immo Kleinschmidt
    Citation: Malaria Journal 2007 6:52
  19. Little is known about children undergoing critical care for malaria. The purpose of this survey was to evaluate the outcome in African children requiring endotracheal intubation for life-threatening malaria.

    Authors: Patrick Gérardin, Christophe Rogier, Amadou S Ka, Philippe Jouvencel, Bakary Diatta and Patrick Imbert
    Citation: Malaria Journal 2007 6:51
  20. The origin of highly competent malaria vectors has been linked to productive larval habitats in the field, but there isn't solid quantitative or qualitative data to support it. To test this, the effect of larv...

    Authors: Bernard A Okech, Louis C Gouagna, Guiyun Yan, John I Githure and John C Beier
    Citation: Malaria Journal 2007 6:50
  21. Capacity strengthening of rural communities, and the various actors that support them, is needed to enable them to lead their own malaria control programmes. Here the existing capacity of a rural community in ...

    Authors: Pamela Opiyo, W Richard Mukabana, Ibrahim Kiche, Evan Mathenge, Gerry F Killeen and Ulrike Fillinger
    Citation: Malaria Journal 2007 6:48
  22. Malaria control strategies are designed as a solution for either the whole region or the whole country and are assumed to suit every setting. There is a need to shift from this assumption because transmission ...

    Authors: Yazoumé Yé, Catherine Kyobutungi, Valérie R Louis and Rainer Sauerborn
    Citation: Malaria Journal 2007 6:46
  23. Enolase (2-Phospho-D-glycerate hydrolase; EC is one of the glycolytic enzymes, whose levels are highly elevated in malaria parasite infected red blood cells. In several organisms, enolases have been ...

    Authors: Ipsita Pal-Bhowmick, Hardeep K Vora and Gotam K Jarori
    Citation: Malaria Journal 2007 6:45
  24. The main objective of this study was to assess the influence of gas mixtures on in vitro Plasmodium falciparum growth and 50% inhibitory concentration (IC50) for chloroquine.

    Authors: Sébastien Briolant, Philippe Parola, Thierry Fusaï, Marilyn Madamet-Torrentino, Eric Baret, Joël Mosnier, Jean P Delmont, Daniel Parzy, Philippe Minodier, Christophe Rogier and Bruno Pradines
    Citation: Malaria Journal 2007 6:44
  25. Malaria during first few months of life may be due to transplacental transfer of parasitized maternal erythrocytes. Although IgG and IgM antimalarial antibodies can be detected in maternal blood, only IgG anti...

    Authors: Neena Valecha, Sunita Bhatia, Sadhna Mehta, Sukla Biswas and Aditya P Dash
    Citation: Malaria Journal 2007 6:43
  26. Co-infection with falciparum malaria and leptospirosis is uncommon. The aim of this study is to report a case of severe sepsis secondary to dual infection with falciparum malaria and leptospirosis. The literat...

    Authors: Rajagopala Srinivas, Ritesh Agarwal and Dheeraj Gupta
    Citation: Malaria Journal 2007 6:42
  27. Chloroquine (CQ) has been in use in Africa for a long time. Because of misuse, this drug has now lost its efficacy due to the emergence of resistance strains in most parts of Africa. Recently, it was shown tha...

    Authors: Olusola Ojurongbe, Titus O Ogungbamigbe, Adetayo F Fagbenro-Beyioku, Rolf Fendel, Peter G Kremsner and Jürgen FJ Kun
    Citation: Malaria Journal 2007 6:41
  28. Early recognition of symptoms and signs perceived as malaria are important for effective case management, as few laboratories are available at peripheral health facilities. The validity and reliability of clin...

    Authors: Richard Ndyomugyenyi, Pascal Magnussen and Siân Clarke
    Citation: Malaria Journal 2007 6:39
  29. To manage the kdr pyrethroid-resistance in Anopheline malaria vectors, new compounds or new strategies are urgently needed. Recently, mixing repellents (DEET) and a non-pyrethroid insecticide (propoxur) was shown...

    Authors: Cédric Pennetier, Vincent Corbel, Pélagie Boko, Abibatou Odjo, Raphaël N'Guessan, Bruno Lapied and Jean-Marc Hougard
    Citation: Malaria Journal 2007 6:38
  30. In Cambodia, estimates of the malaria burden rely on a public health information system that does not record cases occurring among remote populations, neither malaria cases treated in the private sector nor as...

    Authors: Sandra Incardona, Sirenda Vong, Lim Chiv, Pharath Lim, Sina Nhem, Rithy Sem, Nimol Khim, Socheat Doung, Odile Mercereau-Puijalon and Thierry Fandeur
    Citation: Malaria Journal 2007 6:37
  31. Plasmodium falciparum is the predominant human malaria species in Mozambique and a lead cause of mortality among children and pregnant women nationwide. Sulphadoxine/pyrimethamine (S/P) is used as first line anti...

    Authors: Natércia Fernandes, Paula Figueiredo, Virgilio E do Rosário and Pedro Cravo
    Citation: Malaria Journal 2007 6:35
  32. Polymorphism in the pfcrt gene underlies Plasmodium falciparum chloroquine resistance (CQR), as sensitive strains consistently carry lysine (K), while CQR strains carry threonine (T) at the codon 76. Previous stu...

    Authors: Jeana T DaRe, Rajeev K Mehlotra, Pascal Michon, Ivo Mueller, John Reeder, Yagya D Sharma, Mark Stoneking and Peter A Zimmerman
    Citation: Malaria Journal 2007 6:34
  33. Extra-Amazonian autochthonous Plasmodium vivax infections have been reported in mountainous regions surrounded by the Atlantic Forest in Espírito Santo state, Brazil.

    Authors: Crispim Cerutti Junior, Marcos Boulos, Arnídio F Coutinho, Maria do Carmo LD Hatab, Aloísio Falqueto, Helder R Rezende, Ana Maria RC Duarte, William Collins and Rosely S Malafronte
    Citation: Malaria Journal 2007 6:33
  34. Adhesion of Plasmodium-infected red blood cells (iRBC) to different host cells, ranging from endothelial to red blood cells, is associated to malaria pathology. In vitro studies have shown the relevance of CD36 f...

    Authors: Margarida Cunha-Rodrigues, Sílvia Portugal, Maria Febbraio and Maria M Mota
    Citation: Malaria Journal 2007 6:32
  35. Zambia was the first African country to change national antimalarial treatment policy to artemisinin-based combination therapy – artemether-lumefantrine. An evaluation during the early implementation phase rev...

    Authors: Dejan Zurovac, Mickey Ndhlovu, Nawa Sipilanyambe, Pascalina Chanda, Davidson H Hamer, Jon L Simon and Robert W Snow
    Citation: Malaria Journal 2007 6:31
  36. Insecticide resistance in malaria vector mosquitoes presents a serious problem for those involved in control of this disease. South Africa experienced a severe malaria epidemic during 1999/2000 due to pyrethro...

    Authors: Joel C Mouatcho, Keith Hargreaves, Lizette L Koekemoer, Basil D Brooke, Shüne V Oliver, Richard H Hunt and Maureen Coetzee
    Citation: Malaria Journal 2007 6:30
  37. Artesunate-amodiaquine combination for the treatment of childhood malaria is one of the artemisinin combination therapies (ACTs) recommended by National authorities in many African countries today. Effectivene...

    Authors: Sunny Oyakhirome, Marc Pötschke, Norbert G Schwarz, Jenny Dörnemann, Matthias Laengin, Carmen Ospina Salazar, Bertrand Lell, Jürgen FJ Kun, Peter G Kremsner and Martin P Grobusch
    Citation: Malaria Journal 2007 6:29
  38. Single nucleotide polymorphisms (SNPs) in the Plasmodium vivax dihydrofolate reductase (Pfdhfr) and dihydropteroate synthetase (Pvdhps) genes cause parasite resistance to the antifolate drug combination, sulphado...

    Authors: Mette L Schousboe, Rupika S Rajakaruna, Ali Salanti, Hapuarachchige C Hapuarachchi, Gawrie NL Galappaththy, Ib C Bygbjerg, Priyanie H Amerasinghe, Flemming Konradsen and Michael Alifrangis
    Citation: Malaria Journal 2007 6:28
  39. In areas of stable transmission, malaria during pregnancy is associated with severe maternal and foetal outcomes, especially low birth weight (LBW). To prevent these complications, weekly chloroquine (CQ) chem...

    Authors: Lise Denoeud, Nadine Fievet, Agnès Aubouy, Paul Ayemonna, Richard Kiniffo, Achille Massougbodji and Michel Cot
    Citation: Malaria Journal 2007 6:27
  40. Identification of Anopheles gambiae s.s. and Anopheles arabiensis from field-collected Anopheles gambiae s.l. is often necessary in basic and applied research, and in operational control programmes. The currently...

    Authors: Edward D Walker, Alisha R Thibault, Annette P Thelen, Blair A Bullard, Juan Huang, Maurice R Odiere, Nabie M Bayoh, Elizabeth E Wilkins and John M Vulule
    Citation: Malaria Journal 2007 6:23

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