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  1. Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a complication of malaria with a lethality rate of up to 80% despite anti-malarial treatment. It is characterized by a vast infiltration of l...

    Authors: Leen Vandermosten, Thao-Thy Pham, Hendrik Possemiers, Sofie Knoops, Evelien Van Herck, Julie Deckers, Blandine Franke-Fayard, Tracey J. Lamb, Chris J. Janse, Ghislain Opdenakker and Philippe E. Van den Steen
    Citation: Malaria Journal 2018 17:102
    Content type: Research Published on:

  2. Oxidative agents can cause acute haemolytic anaemia in persons with G6PD deficiency. Understanding the relationship between G6PD genotype and the phenotypic expression of the enzyme deficiency is necessary so ...

    Authors: Cindy S. Chu, Germana Bancone, François Nosten, Nicholas J. White and Lucio Luzzatto
    Citation: Malaria Journal 2018 17:101
    Content type: Review Published on:

  3. The Government of Tanzania is the main source of long-lasting insecticidal nets (LLINs) for its population. Mosquito nets (treated and untreated) are also available in the commercial market. To sustain investm...

    Authors: Zawadi M. Mboma, Hans J. Overgaard, Sarah Moore, John Bradley, Jason Moore, Dennis J. Massue, Karen Kramer, Jo Lines and Lena M. Lorenz
    Citation: Malaria Journal 2018 17:100
    Content type: Research Published on:

  4. Village health workers (VHWs) in five villages in Bugoye subcounty (Kasese District, Uganda) provide integrated community case management (iCCM) services, in which VHWs evaluate and treat malaria, pneumonia, a...

    Authors: James S. Miller, Lacey English, Michael Matte, Rapheal Mbusa, Moses Ntaro, Shem Bwambale, Jessica Kenney, Mark J. Siedner, Raquel Reyes, Patrick T. Lee, Edgar Mulogo and Geren S. Stone
    Citation: Malaria Journal 2018 17:99
    Content type: Research Published on:

  5. In Niger, malaria transmission is markedly seasonal with most of the disease burden occurring in children during the rainy season. Seasonal malaria chemoprevention (SMC) with amodiaquine plus sulfadoxine–pyrim...

    Authors: Rebecca F. Grais, Ibrahim M. Laminou, Lynda Woi-Messe, Rockyath Makarimi, Seidou H. Bouriema, Celine Langendorf, Alfred Amambua-Ngwa, Umberto D’Alessandro, Philippe J. Guérin, Thierry Fandeur and Carol H. Sibley
    Citation: Malaria Journal 2018 17:98
    Content type: Research Published on:

  6. Although death records are useful for planning and monitoring health interventions, such information is limited in most developing countries. Verbal autopsy (VA) interviews are alternatively used to determine ...

    Authors: Daniel P. Challe, Mathias L. Kamugisha, Bruno P. Mmbando, Filbert Francis, Mercy G. Chiduo, Celine I. Mandara, Samuel Gesase, Omari Abdul, Martha M. Lemnge and Deus S. Ishengoma
    Citation: Malaria Journal 2018 17:97
    Content type: Research Published on:

  7. Public health strategies for malaria in endemic countries aim to prevent transmission of the disease and control the vector. This historical analysis considers the strategies for vector control developed durin...

    Authors: Gabriel Gachelin, Paul Garner, Eliana Ferroni, Jan Peter Verhave and Annick Opinel
    Citation: Malaria Journal 2018 17:96
    Content type: Review Published on:

  8. Continuous training of health workers is a key intervention to maintain their good performance and keep their vigilance during malaria elimination programmes. However, countries progressing toward malaria elim...

    Authors: Guangyu Lu, Yaobao Liu, Jinsong Wang, Xiangming Li, Xing Liu, Claudia Beiersmann, Yu Feng, Jun Cao and Olaf Müller
    Citation: Malaria Journal 2018 17:95
    Content type: Research Published on:

  9. In this semi-field study, a new polymer-enhanced deltamethrin formulation, K-Othrine® PolyZone, was compared to a standard deltamethrin product for residual activity against a susceptible strain of laboratory-rea...

    Authors: James C. Dunford, Alden S. Estep, Christy M. Waits, Alec G. Richardson, David F. Hoel, Karin Horn, Todd W. Walker, Jessika S. Blersch, Jerry D. Kerce and Robert A. Wirtz
    Citation: Malaria Journal 2018 17:94
    Content type: Research Published on:

  10. Indoor residual spraying (IRS) is a key tool in the fight to control, eliminate and ultimately eradicate malaria. IRS protection is based on a communal effect such that an individual’s protection primarily rel...

    Authors: Daniel J. Bridges, Derek Pollard, Anna M. Winters, Benjamin Winters, Chadwick Sikaala, Silvia Renn and David A. Larsen
    Citation: Malaria Journal 2018 17:93
    Content type: Research Published on:

  11. Plasmodium falciparum, the most dominant species in sub-Saharan Africa, causes the most severe clinical malaria manifestations. In resource-limited Ghana, where malaria and HIV geographically overlap, histidine-r...

    Authors: Ewurama D. A. Owusu, Samson K. Djonor, Charles A. Brown, Martin P. Grobusch and Petra F. Mens
    Citation: Malaria Journal 2018 17:92
    Content type: Research Published on:

  12. Plasmodium falciparum malaria remains a major health burden and genomic research represents one of the necessary approaches for continued progress towards malaria control and elimination. Sample acquisition for t...

    Authors: Sidsel Nag, Poul-Erik Kofoed, Johan Ursing, Camilla Koldbæk Lemvigh, Rosa Lundbye Allesøe, Amabelia Rodrigues, Christina Aaby Svendsen, Jacob Dyring Jensen, Michael Alifrangis, Ole Lund and Frank M. Aarestrup
    Citation: Malaria Journal 2018 17:91
    Content type: Methodology Published on:

  13. Anopheles arabiensis is a key vector for the transmission of human malaria in sub-Saharan Africa. Over the past 10,000 years, humans have successfully cultivated grasses and altered the landscape, creating An. ar...

    Authors: Betelehem Wondwosen, Göran Birgersson, Habte Tekie, Baldwyn Torto, Rickard Ignell and Sharon R. Hill
    Citation: Malaria Journal 2018 17:90
    Content type: Research Published on:

  14. Plasmodium vivax remains an important cause of morbidity and mortality across the Americas, Horn of Africa, East and South East Asia. Control of transmission has been hampered by emergence of chloroquine resistan...

    Authors: Thomas C. S. Martin and Joseph M. Vinetz
    Citation: Malaria Journal 2018 17:89
    Content type: Opinion Published on:

  15. Countries planning malaria elimination must adapt from sustaining universal control to targeted intervention and surveillance. Decisions to make this transition require interpretable information, including mal...

    Authors: Emanuele Giorgi, Ali Abdirahman Osman, Abdikarin Hussein Hassan, Abdi Abdillahi Ali, Faisa Ibrahim, Jamal G. H. Amran, Abdisalan M. Noor and Robert W. Snow
    Citation: Malaria Journal 2018 17:88
    Content type: Research Published on:

  16. Malaria, a parasitic infection, is a life-threatening disease in South Sumatra Province, Indonesia. This study aimed to investigate the spatial association between malaria occurrence and environmental risk fac...

    Authors: Hamzah Hasyim, Afi Nursafingi, Ubydul Haque, Doreen Montag, David A. Groneberg, Meghnath Dhimal, Ulrich Kuch and Ruth Müller
    Citation: Malaria Journal 2018 17:87
    Content type: Research Published on:

  17. In Loreto Department, Peru, a successful 2005–2010 malaria control programme (known as PAMAFRO) included massive distribution of long-lasting insecticidal nets (LLINs). Additional local distribution of LLINs o...

    Authors: Catharine Prussing, Marta Moreno, Marlon P. Saavedra, Sara A. Bickersmith, Dionicia Gamboa, Freddy Alava, Carl D. Schlichting, Kevin J. Emerson, Joseph M. Vinetz and Jan E. Conn
    Citation: Malaria Journal 2018 17:86
    Content type: Research Published on:

  18. Malaria has historically been entrenched in indigenous populations of the República de Panamá. This scenario occurs despite the fact that successful methods for malaria elimination were developed during the creat...

    Authors: Lisbeth Amarilis Hurtado, José E. Calzada, Chystrie A. Rigg, Milagros Castillo and Luis Fernando Chaves
    Citation: Malaria Journal 2018 17:85
    Content type: Research Published on:

  19. Artemisinin-based combination therapy is the first-line anti-malarial treatment for uncomplicated Plasmodium falciparum infection in Angola. To date, the prevalence of polymorphisms in the pfk13 gene, associated ...

    Authors: Dragan Ljolje, Pedro Rafael Dimbu, Julia Kelley, Ira Goldman, Douglas Nace, Aleixo Macaia, Eric S. Halsey, Pascal Ringwald, Filomeno Fortes, Venkatachalam Udhayakumar, Eldin Talundzic, Naomi W. Lucchi and Mateusz M. Plucinski
    Citation: Malaria Journal 2018 17:84
    Content type: Research Published on:

  20. Malaria is still one of the serious public health problems in Grande Comore Island, although the number of annual cases has been greatly reduced in recent years. A better understanding of malaria parasite popu...

    Authors: Bo Huang, Fei Tuo, Yuan Liang, Wanting Wu, Guangchao Wu, Shiguang Huang, Qirun Zhong, Xin-zhuan Su, Hongying Zhang, Mingqiang Li, Affane Bacar, Kamal Said Abdallah, Ahamada M. S. A. Mliva, Qi Wang, Zhaoli Yang, Shaoqin Zheng…
    Citation: Malaria Journal 2018 17:83
    Content type: Research Published on:

  21. Chitinase-3-like 1 (CHI3L1) is a glycoprotein elevated in paediatric severe malaria, and an emerging urinary biomarker of acute kidney injury (AKI). Based on the hypothesis that elevated CHI3L1 levels in malar...

    Authors: Andrea L. Conroy, Michael T. Hawkes, Robyn Elphinstone, Robert O. Opoka, Sophie Namasopo, Christopher Miller, Chandy C. John and Kevin C. Kain
    Citation: Malaria Journal 2018 17:82
    Content type: Research Published on:

  22. Hubei Province, China, has been operating a malaria elimination programme. This study aimed at investigating the epidemiologic characteristics of malaria in Hubei Province (2005–2016) to plan resource allocati...

    Authors: Jing Xia, Xibao Huang, Lingcong Sun, Hong Zhu, Wen Lin, Xiaorong Dong, Dongni Wu, Juan Qiu, Li Zheng, Mumin Cao, Si Liu and Huaxun Zhang
    Citation: Malaria Journal 2018 17:81
    Content type: Research Published on:

  24. Splenomegaly is one of the most common features of malaria. However, spontaneous splenic rupture, although unusual, represents a severe complication often leading to death. It is mostly seen in acute infection...

    Authors: Aleix Elizalde-Torrent, Fernando Val, Ingrid Cardoso C. Azevedo, Wuelton M. Monteiro, Luiz C. L. Ferreira, Carmen Fernández-Becerra, Hernando A. del Portillo and Marcus V. G. Lacerda
    Citation: Malaria Journal 2018 17:79
    Content type: Case report Published on:

  25. Malaria caused by Plasmodium ovale spp. has been neglected by and large from research and has received only little scientific attention during the past decades. Ovale malaria is considered to feature relapses by ...

    Authors: Luzia Veletzky, Mirjam Groger, Heimo Lagler, Julia Walochnik, Herbert Auer, Hans-Peter Fuehrer and Michael Ramharter
    Citation: Malaria Journal 2018 17:78
    Content type: Case report Published on:

  26. Plasmodium parasites are known to impose fitness costs on their vertebrate hosts. Some of these costs are due to the activation of the immune response, which may divert resources away from self-maintenance. Plasm...

    Authors: Jessica Delhaye, Tania Jenkins, Olivier Glaizot and Philippe Christe
    Citation: Malaria Journal 2018 17:77
    Content type: Research Published on:

  27. The Plasmodium vivax Duffy binding protein (PvDBP) has been the most studied ligand binding human reticulocytes to date. This molecule has a cysteine-rich domain in region II (RII) which has been used as control ...

    Authors: Darwin Andrés Moreno-Pérez, Luis Alfredo Baquero, Maritza Bermúdez, Laura Alejandra Gómez-Muñoz, Yahson Varela and Manuel Alfonso Patarroyo
    Citation: Malaria Journal 2018 17:76
    Content type: Methodology Published on:

  28. To limit the spread and impact of anti-malarial drug resistance and react accordingly, surveillance systems able to detect and track in real-time its emergence and spread need to be strengthened or in some pla...

    Authors: Christian Nsanzabana, Djibrine Djalle, Philippe J. Guérin, Didier Ménard and Iveth J. González
    Citation: Malaria Journal 2018 17:75
    Content type: Review Published on:

  29. There is evidence that suggests that undernutrition has a detrimental effect on malarial immunity in children. The aim of the study was to discover whether nutrient supplementation improved development of mala...

    Authors: Priyanka Barua, Upeksha P. Chandrasiri, James G. Beeson, Kathryn G. Dewey, Kenneth Maleta, Per Ashorn and Stephen J. Rogerson
    Citation: Malaria Journal 2018 17:74
    Content type: Research Published on:

  30. Malaria transmission is driven by multiple factors, including complex and multifaceted connections between malaria transmission, socioeconomic conditions, climate and interventions. Forecasting models should a...

    Authors: Margaux L. Sadoine, Audrey Smargiassi, Valéry Ridde, Lucy S. Tusting and Kate Zinszer
    Citation: Malaria Journal 2018 17:73
    Content type: Research Published on:

  31. Rapid diagnosis of malaria using acridine orange (AO) staining and a light microscope with a halogen lamp and interference filter was deployed in some malaria-endemic countries. However, it has not been widely...

    Authors: Masatsugu Kimura, Isao Teramoto, Chim W. Chan, Zulkarnain Md Idris, James Kongere, Wataru Kagaya, Fumihiko Kawamoto, Ryoko Asada, Rie Isozumi and Akira Kaneko
    Citation: Malaria Journal 2018 17:72
    Content type: Methodology Published on:

  32. Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is one of leading blood stage malaria vaccine candidates. However, genetic variation and antigenic diversity identified in global PfAMA-1 are major hurdle...

    Authors: Jung-Mi Kang, Jinyoung Lee, Mya Moe, Hojong Jun, Hương Giang Lê, Tae Im Kim, Thị Lam Thái, Woon-Mok Sohn, Moe Kyaw Myint, Khin Lin, Ho-Joon Shin, Tong-Soo Kim and Byoung-Kuk Na
    Citation: Malaria Journal 2018 17:71
    Content type: Research Published on:

  33. The malaria rapid diagnosis testing (RDT) landscape is rapidly evolving in health care delivery in Nigeria with many stakeholders playing or having potential for critical roles. A recent UNITAID grant supporte...

    Authors: Babatunde Odugbemi, Chijioke Ezeudu, Anyiekere Ekanem, Maxwell Kolawole, Idowu Akanmu, Aderemi Olawole, Nkabono Nglass, Chinwe Nze, Edward Idenu, Bala Mohammed Audu, Godwin Ntadom, Wondimagegnehu Alemu, Rex Mpazanje, Jane Cunningham, Augustine Akubue, Tolu Arowolo…
    Citation: Malaria Journal 2018 17:70
    Content type: Meeting Report Published on:

  34. Malaria poses a significant public health threat globally, across Africa and in Ethiopia. The use of long-lasting insecticidal nets (LLINs) is currently a proven prevention mechanism. Evidence is building on w...

    Authors: Zerihun Doda, Tarekegn Solomon, Eskindir Loha, Taye Gari and Bernt Lindtjørn
    Citation: Malaria Journal 2018 17:69
    Content type: Research Published on:

  35. Plasmodium falciparum malaria is still one of the most deadly pathology worldwide. Efficient treatment is jeopardized by parasite resistance to artemisinin and its derivatives, and by poor access to treatment in ...

    Authors: Mahamane Haidara, Mohamed Haddad, Adama Denou, Guillaume Marti, Sandra Bourgeade-Delmas, Rokia Sanogo, Geneviève Bourdy and Agnès Aubouy
    Citation: Malaria Journal 2018 17:68
    Content type: Research Published on:

  36. Submicroscopic malaria parasitaemia is common in both high- and low-endemicity settings, but its clinical consequences are unclear.

    Authors: Shereen Katrak, Patience Nayebare, John Rek, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, Moses Kamya, Grant Dorsey, Philip J. Rosenthal and Bryan Greenhouse
    Citation: Malaria Journal 2018 17:67
    Content type: Research Published on:

  37. In 2015, Mozambique piloted a new model of long-lasting insecticidal nets (LLINs) delivery in a campaign. The new delivery model was used in two rural districts were, and two others were considered as control,...

    Authors: Jorge A. H. Arroz, Baltazar Candrinho, Chandana Mendis, Pablo Varela, João Pinto and Maria do Rosário O. Martins
    Citation: Malaria Journal 2018 17:66
    Content type: Research Published on:

  38. Malaria is one of the major causes of childhood death in sub-Saharan countries. A reliable estimation of malaria prevalence is important to guide and monitor progress toward control and elimination. The aim of...

    Authors: Elvire Mfueni, Brecht Devleesschauwer, Angel Rosas-Aguirre, Carine Van Malderen, Patrick T. Brandt, Bernhards Ogutu, Robert W. Snow, Léon Tshilolo, Dejan Zurovac, Dieter Vanderelst and Niko Speybroeck
    Citation: Malaria Journal 2018 17:65
    Content type: Research Published on:

  39. Scaling-up of effective anti-malarial control strategies in Central-West region of Senegal has resulted in the sharp decline in malaria prevalence in this area. However, despite these strategies, residual mala...

    Authors: Ousmane Sy, El Hadji Amadou Niang, Magatte Ndiaye, Lassana Konaté, Abdoulaye Diallo, Elhadji Conco Ciré Ba, Fassiath Tairou, Elhadji Diouf, Badara Cissé, Oumar Gaye and Ousmane Faye
    Citation: Malaria Journal 2018 17:64
    Content type: Research Published on:

  40. Malaria is no longer endemic in Italy since 1970 when the World Health Organization declared Italy malaria-free, but it is now the most commonly imported disease. The aim of the study was to analyse the trend ...

    Authors: Adriana Calderaro, Giovanna Piccolo, Sara Montecchini, Mirko Buttrini, Sabina Rossi, Maria Loretana Dell’Anna, Valeria De Remigis, Maria Cristina Arcangeletti, Carlo Chezzi and Flora De Conto
    Citation: Malaria Journal 2018 17:63
    Content type: Research Published on:

  41. Whilst there have been substantial reductions in malaria transmission over the past decade, in many countries in West and Central Africa the malaria burden remains high. Monitoring and evaluation of malaria tr...

    Authors: Jackie Cook, Dianna Hergott, Wonder Phiri, Matilde Riloha Rivas, John Bradley, Luis Segura, Guillermo Garcia, Chris Schwabe and Immo Kleinschmidt
    Citation: Malaria Journal 2018 17:62
    Content type: Research Published on:

  42. Severe forms of malaria (SM) are an outcome of Plasmodium falciparum infection and can cause death especially in children under 4 years of age. RNASE3 (ECP) has been identified as an inhibitor of Plasmodium paras...

    Authors: Gora Diop, Céline Derbois, Cheikh Loucoubar, Babacar Mbengue, Bineta Niakhana Ndao, Fatou Thiam, Alassane Thiam, Rokhaya Ndiaye, Yakhya Dieye, Robert Olaso, Jean-Francois Deleuze and Alioune Dieye
    Citation: Malaria Journal 2018 17:61
    Content type: Research Published on:

  43. Four Plasmodium falciparum genetic crosses (HB3×3D7, HB3×Dd2, 7G8×GB4, and 803×GB4) have produced sets of recombinant progeny that are widely used for malaria research, including investigations of anti-malarial d...

    Authors: Christine E. Figan, Juliana M. Sá, Jianbing Mu, Viviana A. Melendez-Muniz, Chia Hao Liu and Thomas E. Wellems
    Citation: Malaria Journal 2018 17:60
    Content type: Methodology Published on:

  44. The automated haematology analyzer XN-30 (Sysmex, Kobe, Japan) easily and rapidly detects malarial parasites in clinical blood samples using flow cytometry. The XN-30 analyzer is able to distinguish each devel...

    Authors: Takahiro Tougan, Yuhgi Suzuki, Sawako Itagaki, Munehisa Izuka, Yuji Toya, Kinya Uchihashi and Toshihiro Horii
    Citation: Malaria Journal 2018 17:59
    Content type: Methodology Published on:

  45. Malaria is one of the primary health concerns in Madagascar. Based on the duration and intensity of transmission, Madagascar is divided into five epidemiological strata that range from low to mesoendemic trans...

    Authors: Felana A. Ihantamalala, Feno M. J. Rakotoarimanana, Tanjona Ramiadantsoa, Jean Marius Rakotondramanga, Gwenaëlle Pennober, Fanjasoa Rakotomanana, Simon Cauchemez, Charlotte J. E. Metcalf, Vincent Herbreteau and Amy Wesolowski
    Citation: Malaria Journal 2018 17:58
    Content type: Research Published on:

  46. CYP2D6 pathway mediates the activation of primaquine into active metabolite(s) in hepatocytes. CYP2D6 is highly polymorphic, encoding CYP2D6 isoforms with normal, reduced, null or increased activity. It is hypoth...

    Authors: Larissa W. Brasil, Fernanda Rodrigues-Soares, Ana B. Santoro, Anne C. G. Almeida, Andrea Kühn, Rajendranath Ramasawmy, Marcus V. G. Lacerda, Wuelton M. Monteiro and Guilherme Suarez-Kurtz
    Citation: Malaria Journal 2018 17:57
    Content type: Research Published on:

  47. Suriname has moved from being the country with the highest annual parasite index in the Americas to one on the threshold of elimination. The progress toward elimination in the stable populations of Suriname be...

    Authors: Edward D. van Eer, Gustavo Bretas and Hélène Hiwat
    Citation: Malaria Journal 2018 17:56
    Content type: Research Published on:

  48. A distinctive feature of Plasmodium vivax infections is the overall low parasite density in peripheral blood. Thus, identifying asymptomatic infected individuals in endemic communities requires diagnostic tests w...

    Authors: Maria Gruenberg, Clara Antunes Moniz, Natalie Ellen Hofmann, Rahel Wampfler, Cristian Koepfli, Ivo Mueller, Wuelton Marcelo Monteiro, Marcus Lacerda, Gisely Cardoso de Melo, Andrea Kuehn, Andre M. Siqueira and Ingrid Felger
    Citation: Malaria Journal 2018 17:55
    Content type: Review Published on:

  49. Routine field diagnosis of malaria is a considerable challenge in rural and low resources endemic areas mainly due to lack of personnel, training and sample processing capacity. In addition, differential diagn...

    Authors: Alejandra Ortiz-Ruiz, María Postigo, Sara Gil-Casanova, Daniel Cuadrado, José M. Bautista, José Miguel Rubio, Miguel Luengo-Oroz and María Linares
    Citation: Malaria Journal 2018 17:54
    Content type: Research Published on:

  50. Two mass drug administrations (MDA) against falciparum malaria were conducted in 2015–16, one as operational research in northern Cambodia, and the other as a clinical trial in western Cambodia. During an Apri...

    Authors: Thomas J. Peto, Mark Debackere, William Etienne, Lieven Vernaeve, Rupam Tripura, Gregoire Falq, Chan Davoeung, Chea Nguon, Huy Rekol, Lorenz von Seidlein, Arjen M. Dondorp, Nou Sanann, Phaik Yeong Cheah, Martin De Smet, Christopher Pell and Jean-Marie Kindermans
    Citation: Malaria Journal 2018 17:53
    Content type: Meeting Report Published on:
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Malaria Journal

ISSN: 1475-2875

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