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  1. A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment ...

    Authors: Karen I Barnes, Niklas Lindegardh, Olumide Ogundahunsi, Piero Olliaro, Christopher V Plowe, Milijaona Randrianarivelojosia, Grace O Gbotosho, William M Watkins, Carol H Sibley and Nicholas J White
    Citation: Malaria Journal 2007 6:122
  2. Intrinsic resistance of Plasmodium falciparum is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ab...

    Authors: David J Bacon, Ronan Jambou, Thierry Fandeur, Jacques Le Bras, Chansuda Wongsrichanalai, Mark M Fukuda, Pascal Ringwald, Carol Hopkins Sibley and Dennis E Kyle
    Citation: Malaria Journal 2007 6:120
  3. In sub-Saharan areas, malaria transmission was mainly ensured by Anopheles. gambiae s.l. and Anopheles. funestus vectors. The immune response status to Plasmodium falciparum was evaluated in children living in tw...

    Authors: Jean Biram Sarr, Franck Remoue, Badara Samb, Ibrahima Dia, Sohibou Guindo, Cheikh Sow, Sophie Maiga, Seydou Tine, Cheikh Thiam, Anne-Marie Schacht, François Simondon, Lassana Konate and Gilles Riveau
    Citation: Malaria Journal 2007 6:117
  4. The Nias district of the North Sumatra Province of Indonesia has long been known to be endemic for malaria. Following the economic crisis at the end of 1998 and the subsequent tsunami and earthquake, in Decemb...

    Authors: Din Syafruddin, Puji BS Asih, Isra Wahid, Rita M Dewi, Sekar Tuti, Idaman Laowo, Waozidohu Hulu, Pardamean Zendrato, Ferdinand Laihad and Anuraj H Shankar
    Citation: Malaria Journal 2007 6:116
  5. Malaria was endemic in the Rhône-Alpes area of eastern France in the 19th century and life expectancy was particularly shortened in Alpine valleys. This study was designed to determine how the disease affected pe...

    Authors: Julien Sérandour, Jacky Girel, Sebastien Boyer, Patrick Ravanel, Guy Lemperière and Muriel Raveton
    Citation: Malaria Journal 2007 6:115
  6. A comparison was made between local malaria transmission and malaria imported by travellers to identify the utility of national and regional annual parasite index (API) in predicting malaria risk and its value...

    Authors: Ron H Behrens, Bernadette Carroll, Jiri Beran, Olivier Bouchaud, Urban Hellgren, Christoph Hatz, Tomas Jelinek, Fabrice Legros, Nikolai Mühlberger, Bjørn Myrvang, Heli Siikamäki and Leo Visser
    Citation: Malaria Journal 2007 6:114
  7. A previous study showed for Anopheles gambiae s.s. a gradation of feeding preference on common plant species growing in a malaria holoendemic area in western Kenya. The present follow-up study determines whether ...

    Authors: Hortance Manda, Louis C Gouagna, Woodbridge A Foster, Robert R Jackson, John C Beier, John I Githure and Ahmed Hassanali
    Citation: Malaria Journal 2007 6:113
  8. Knockdown resistance (kdr) is a well-characterized mechanism of resistance to pyrethroid insecticides in many insect species and is caused by point mutations of the pyrethroid target site the para-type sodium cha...

    Authors: Chris Bass, Dimitra Nikou, Martin J Donnelly, Martin S Williamson, Hilary Ranson, Amanda Ball, John Vontas and Linda M Field
    Citation: Malaria Journal 2007 6:111
  9. Malaria control measures were initiated from in October 2005 to August 2006 in the Lower Moshi irrigation schemes, Tanzania. This manuscript reports on the entomological evaluation of the impact of pyrethroid-...

    Authors: Aneth M Mahande, Franklin W Mosha, Johnson M Mahande and Eliningaya J Kweka
    Citation: Malaria Journal 2007 6:109
  10. The Plasmodium falciparum dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) are enzymes of central importance in parasite metabolism. The dhfr and dhps gene mutations are known to be associated...

    Authors: Ishraga E A-Elbasit, Michael Alifrangis, Insaf F Khalil, Ib C Bygbjerg, Emad M Masuadi, Mustafa I Elbashir and Hayder A Giha
    Citation: Malaria Journal 2007 6:108
  11. Mosquito stage malaria vaccines are designed to induce an immune response in the human host that will block the parasite's growth in the mosquito and consequently block transmission of the parasite. A mosquito...

    Authors: Kazutoyo Miura, David B Keister, Olga V Muratova, Jetsumon Sattabongkot, Carole A Long and Allan Saul
    Citation: Malaria Journal 2007 6:107
  12. The literature on health care seeking behaviour in sub-Saharan Africa for children suffering from malaria is quite extensive. This literature, however, is predominately quantitative and, inevitably, fails to e...

    Authors: Claudia Beiersmann, Aboubakary Sanou, Evelyn Wladarsch, Manuela De Allegri, Bocar Kouyaté and Olaf Müller
    Citation: Malaria Journal 2007 6:106
  13. The National Vector Borne Disease Control Programme (NVBDCP) of the Ministry of Health, Government of India is reporting about 2 million parasite positive cases each year, although case incidence is 30-fold or...

    Authors: Vinod P Sharma
    Citation: Malaria Journal 2007 6:105
  14. The goal of Roll Back Malaria (RBM) is to reduce malaria morbidity and mortality by 50% by the year 2010, and still further thereafter until the disease becomes no more a threat to public health. To contribute...

    Authors: Seth Owusu-Agyei, Elizabeth Awini, Francis Anto, Thomas Mensah-Afful, Martin Adjuik, Abraham Hodgson, Edwin Afari and Fred Binka
    Citation: Malaria Journal 2007 6:103
  15. Blood group O has been significantly associated with increased placental malaria infection in primiparae and reduced risk of infection in multiparae in the Gambia, an area with markedly seasonal malaria transm...

    Authors: Edward Senga, Maria-Paz Loscertales, KEB Makwakwa, George N Liomba, Charles Dzamalala, Peter N Kazembe and Bernard J Brabin
    Citation: Malaria Journal 2007 6:102
  16. The cost of mosquito repellents in Latin America has discouraged their wider use among the poor. To address this problem, a low-cost repellent was developed that reduces the level of expensive repellent active...

    Authors: Sarah J Moore, Samuel T Darling, Moisés Sihuincha, Norma Padilla and Gregor J Devine
    Citation: Malaria Journal 2007 6:101
  17. The most important factor for effective zooprophylaxis in reducing malaria transmission is a predominant population of a strongly zoophilic mosquito, Anopheles arabiensis. The feeding preference behaviour of Anop...

    Authors: Aneth Mahande, Franklin Mosha, Johnson Mahande and Eliningaya Kweka
    Citation: Malaria Journal 2007 6:100
  18. Severe falciparum malaria in children was studied as part of the characterization of the Kassena-Nankana District Ghana for future malaria vaccine trials. Children aged 6–59 months with diagnosis suggestive of...

    Authors: Abraham R Oduro, Kwadwo A Koram, William Rogers, Frank Atuguba, Patrick Ansah, Thomas Anyorigiya, Akosua Ansah, Francis Anto, Nathan Mensah, Abraham Hodgson and Francis Nkrumah
    Citation: Malaria Journal 2007 6:96
  19. The C-terminal region of merozoite surface protein-1 (MSP-1) is one of the leading candidates for vaccination against the erythrocytic stages of malaria. However, a major concern in the development of MSP-1 ba...

    Authors: Anitha Mamillapalli, Sujatha Sunil, Suraksha S Diwan, Surya K Sharma, Prajesh K Tyagi, Tridibes Adak, Hema Joshi and Pawan Malhotra
    Citation: Malaria Journal 2007 6:95
  20. In 2003, artesunate-amodiaquine (AS+AQ) was introduced as the new first-line treatment for uncomplicated malaria in Burundi. After confirmed diagnosis, treatment was delivered at subsidized prices in public he...

    Authors: Sibylle Gerstl, Sandra Cohuet, Kodjo Edoh, Christopher Brasher, Alexandre Lesage, Jean-Paul Guthmann and Francesco Checchi
    Citation: Malaria Journal 2007 6:94
  21. African highlands often suffer of devastating malaria epidemics, sometimes in conjunction with complex emergencies, making their control even more difficult. In 2000, Burundian highlands experienced a large ma...

    Authors: Natacha Protopopoff, Michel Van Herp, Peter Maes, Tony Reid, Dismas Baza, Umberto D'Alessandro, Wim Van Bortel and Marc Coosemans
    Citation: Malaria Journal 2007 6:93
  22. A combination of artesunate (AS) plus sulphadoxine/pyrimethamine (SP) as first-line and artemether-lumefantrine (AL) as second-line treatment are currently recommended against uncomplicated P. falciparum infectio...

    Authors: Ebtihal A Mukhtar, Nahla B Gadalla, Salah-Eldin G El-zaki, Izdihar Mukhtar, Fathi A Mansour, Ahmed Babiker and Badria B El-Sayed
    Citation: Malaria Journal 2007 6:92
  23. Having reliable forecasts is critical now for producers, malaria-endemic countries and agencies in order to adapt production and procurement of the artemisinin-based combination treatments (ACTs), the new firs...

    Authors: Jean-Marie Kindermans, Daniel Vandenbergh, Ed Vreeke, Piero Olliaro and Jean-Pierre D'Altilia
    Citation: Malaria Journal 2007 6:91
  24. The objective of this study was to investigate whether the infection of C57BL/6 mice by P. berghei ANKA, which causes severe malaria, was modulated by co-infection with Trypanosoma cruzi.

    Authors: Claudia M Egima, Silene F Macedo, Gisela RS Sasso, Charles Covarrubias, Mauro Cortez, Fernando Y Maeda, Fabio T Costa and Nobuko Yoshida
    Citation: Malaria Journal 2007 6:90
  25. Intermittent preventive treatment with sulphadoxine-pyrimethamine (IPT-SP) is currently the recommended regimen for prevention of malaria in pregnancy in endemic areas. This study sets out to evaluate the effe...

    Authors: Catherine O Falade, Bidemi O Yusuf, Francis F Fadero, Olugbenga A Mokuolu, Davidson H Hamer and Lateef A Salako
    Citation: Malaria Journal 2007 6:88
  26. Genetic linkage mapping identified a region of chromosome 2L in the Anopheles gambiae genome that exerts major control over natural infection by Plasmodium falciparum. This 2L Plasmodium-resistance interval was m...

    Authors: Michelle M Riehle, Kyriacos Markianos, Louis Lambrechts, Ai Xia, Igor Sharakhov, Jacob C Koella and Kenneth D Vernick
    Citation: Malaria Journal 2007 6:87
  27. Asexual stage antibody responses following initial Plasmodium falciparum infections in previously healthy adults may inform vaccine development, yet these have not been as intensively studied as they have in popu...

    Authors: Damon P Eisen, Lina Wang, Helene Jouin, E Elsa H Murhandarwati, Casilda G Black, Odile Mercereau-Puijalon and Ross L Coppel
    Citation: Malaria Journal 2007 6:86
  28. The anti-malarial chloroquine can modulate the outcome of infection during the Plasmodium sporogonic development, interfering with Plasmodium gene expression and subsequently, with transmission. The present study...

    Authors: Henrique Silveira, Susana Ramos, Patrícia Abrantes, Luís Filipe Lopes, Virgílio E do Rosario and Mitchell S Abrahamsen
    Citation: Malaria Journal 2007 6:84
  29. Prompt access to effective treatment is central in the fight against malaria. However, a variety of interlinked factors at household and health system level influence access to timely and appropriate treatment...

    Authors: Manuel W Hetzel, Nelly Iteba, Ahmed Makemba, Christopher Mshana, Christian Lengeler, Brigit Obrist, Alexander Schulze, Rose Nathan, Angel Dillip, Sandra Alba, Iddy Mayumana, Rashid A Khatib, Joseph D Njau and Hassan Mshinda
    Citation: Malaria Journal 2007 6:83
  30. Data suggest that antibody responses to malaria parasites merozoite antigens are generally short-lived and this has implications for serological studies and malaria vaccine designs. However, precise data on th...

    Authors: Samson M Kinyanjui, David J Conway, David E Lanar and Kevin Marsh
    Citation: Malaria Journal 2007 6:82
  31. On the borders of Thailand, Plasmodium falciparum has become resistant to nearly all available drugs, and there is an urgent need to find new antimalarial drugs or drug combinations. Ferroquine (SSR97193) is a ne...

    Authors: Marion Barends, Anchalee Jaidee, Nopparat Khaohirun, Pratap Singhasivanon and François Nosten
    Citation: Malaria Journal 2007 6:81
  32. In view of the high level of chloroquine resistance in many countries, WHO has recommended the use of combination therapy with artemisinin derivatives in the treatment of uncomplicated malaria due to Plasmodium f...

    Authors: Babacar Faye, Jean-Louis Ndiaye, Daouda Ndiaye, Yemou Dieng, Oumar Faye and Oumar Gaye
    Citation: Malaria Journal 2007 6:80
  33. Malaria microscopy, while the gold standard for malaria diagnosis, has limitations. Efficacy estimates in drug and vaccine malaria trials are very sensitive to small errors in microscopy endpoints. This fact l...

    Authors: Colin Ohrt, Peter Obare, Ampon Nanakorn, Christine Adhiambo, Ken Awuondo, Wendy Prudhomme O'Meara, Shon Remich, Kurt Martin, Earnest Cook, Jean-Paul Chretien, Carmen Lucas, Joseph Osoga, Peter McEvoy, Martin Lucas Owaga, James Sande Odera and Bernhards Ogutu
    Citation: Malaria Journal 2007 6:79
  34. The var multigene family encodes PfEMP1, which are expressed on the surface of infected erythrocytes and bind to various host endothelial receptors. Antigenic variation of PfEMP1 plays a key role in malaria patho...

    Authors: Madeleine Dahlbäck, Thomas Lavstsen, Ali Salanti, Lars Hviid, David E Arnot, Thor G Theander and Morten A Nielsen
    Citation: Malaria Journal 2007 6:78
  35. Investigation of host responses to blood stages of Plasmodium spp, and the immunopathology associated with this phase of the life cycle are often performed on mice infected directly with infected red blood cel...

    Authors: Luis Fonseca, Elsa Seixas, Geoffrey Butcher and Jean Langhorne
    Citation: Malaria Journal 2007 6:77
  36. Mosquito larval control may prove to be an effective tool for incorporating into integrated vector management (IVM) strategies for reducing malaria transmission. Here the efficacy of microbial larvicides against

    Authors: Silas Majambere, Steven W Lindsay, Clare Green, Balla Kandeh and Ulrike Fillinger
    Citation: Malaria Journal 2007 6:76
  37. During blood feeding, the mosquito injects saliva into the vertebrate host. This saliva contains bioactive components which may play a role in pathogen transmission and in host-vector relationships by inducing...

    Authors: Sylvie Cornelie, Franck Remoue, Souleymane Doucoure, Tofene NDiaye, Francois-Xavier Sauvage, Denis Boulanger and Francois Simondon
    Citation: Malaria Journal 2007 6:75
  38. Malaria rapid diagnostic tests (RDTs) are relatively simple to perform and provide results quickly for making treatment decisions. However, the accuracy and application of RDT results depends on several factor...

    Authors: Devanand Moonasar, Ameena Ebrahim Goga, John Frean, Philip Kruger and Daniel Chandramohan
    Citation: Malaria Journal 2007 6:74
  39. Enhanced production of nitric oxide (NO) following upmodulation of the inducible isoform of NO synthase (iNOS) by haemozoin (HZ), inflammatory cytokines and LPS may provide protection against Plasmodium falciparu...

    Authors: Oleksii A Skorokhod, Evelin Schwarzer, Monica Ceretto and Paolo Arese
    Citation: Malaria Journal 2007 6:73
  40. Sulphadoxine/sulphalene-pyrimethamine (SP) was adopted in Kenya as first line therapeutic for uncomplicated malaria in 1998. By the second half of 2003, there was convincing evidence that SP was failing and ha...

    Authors: Abdinasir A Amin, Dejan Zurovac, Beth B Kangwana, Joanne Greenfield, Dorothy N Otieno, Willis S Akhwale and Robert W Snow
    Citation: Malaria Journal 2007 6:72
  41. Because of the belief that Nairobi is a low risk zone for malaria, little empirical data exists on malaria risk in the area. The aim of this study was to explore the risk of perceived malaria and some associat...

    Authors: Yazoumé Yé, Elizabeth Kimani-Murage, John Kebaso and Frederick Mugisha
    Citation: Malaria Journal 2007 6:71
  42. The study investigated the pharmacokinetics of fosmidomycin when given alone and in combination with clindamycin in patients with acute uncomplicated falciparum malaria.

    Authors: Kesara Na-Bangchang, Ronnatrai Ruengweerayut, Juntra Karbwang, Anurak Chauemung and David Hutchinson
    Citation: Malaria Journal 2007 6:70

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