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  1. Panama is one of eight countries in Mesoamerica that aims to eliminate malaria by 2022. Malaria is concentrated in indigenous and remote regions like Guna Yala, a politically autonomous region where access to ...

    Authors: Darlene Bhavnani, Bernardo García Espinosa, Madeline Baird, Nicholas Presley, Arnaud Le Menach, Christina Bradley, Marcela Outten and Oscar González
    Citation: Malaria Journal 2022 21:297
  2. The use of synthetic insecticides against mosquitoes may lead to resistance development and potential health hazards in humans and the environment. Consequently, a paradigm needs to shift towards the alternati...

    Authors: Merdya Muhammed, Sisay Dugassa, Merga Belina, Sarah Zohdy, Seth R. Irish and Araya Gebresilassie
    Citation: Malaria Journal 2022 21:295
  3. The housing stock of rural sub-Saharan Africa is changing rapidly. With millions of new homes required over the coming decades, there is an opportunity to protect residents by screening homes from malaria mosq...

    Authors: Caroline Jones, A. Matta, Margaret Pinder, Umberto D’Alessandro, Jakob Knudsen and Steve W. Lindsay
    Citation: Malaria Journal 2022 21:294
  4. In 2020–2021, long-lasting insecticidal nets (LLINs) were distributed nationwide in Uganda during the COVID-19 pandemic. A cross-sectional survey was conducted in 12 districts to evaluate the impact of the cam...

    Authors: Jaffer Okiring, Samuel Gonahasa, Martha Nassali, Jane F. Namuganga, Irene Bagala, Catherine Maiteki‑Sebuguzi, Jimmy Opigo, Isaiah Nabende, Joanita Nangendo, Jane Kabami, Isaac Ssewanyana, Steven M. Kiwuwa, Joaniter I. Nankabirwa, Grant Dorsey, Jessica Briggs, Moses R. Kamya…
    Citation: Malaria Journal 2022 21:293
  5. The prevalence of small for gestational age (SGA) may vary depending on the chosen weight-for-gestational-age reference chart. An individual participant data meta-analysis was conducted to assess the implicati...

    Authors: George Mtove, Daniel T. R. Minja, Omari Abdul, Samwel Gesase, Kenneth Maleta, Titus H. Divala, Noel Patson, Ulla Ashorn, Miriam K. Laufer, Mwayiwawo Madanitsa, Per Ashorn, Don Mathanga, Jobiba Chinkhumba, Julie R. Gutman, Feiko O. ter Kuile, Sofie Lykke Møller…
    Citation: Malaria Journal 2022 21:292
  6. Malaria still kills young children in rural endemic areas because early treatment is not available. Thus, the World Health Organization recommends the administration of artesunate suppositories as pre-referral...

    Authors: Yobouet Ines Kouakou, Aurelien Millet, Elodie Fromentin, Nathalie Hauchard, Gonçalo Farias, Maxime Fieux, Aurelie Coudert, Roukayatou Omorou, Ibrahim Bin Sa’id, Adeline Lavoignat, Guillaume Bonnot, Anne-Lise Bienvenu and Stephane Picot
    Citation: Malaria Journal 2022 21:291
  7. Primaquine is activated by CYP2D6 in the hepatocytes. In Korea, primaquine is the only hypnozoitocidal agent used for patients with vivax malaria. Thus, patients with poor CYP2D6 activity could have an increas...

    Authors: Sungim Choi, Heun Choi, Seong Yeon Park, Yee Gyung Kwak, Je Eun Song, So Youn Shin, Ji Hyeon Baek, Hyun-IL Shin, Shin-Hyung Cho, Sang-Eun Lee, Jeong-Ran Kwon, Sookkyung Park, Miyoung Kim, Hong Sang Oh, Yong Chan Kim, Min Jae Kim…
    Citation: Malaria Journal 2022 21:289
  8. The World Health Organization (WHO) has certificated China malaria free, but imported malaria is a continuous challenge in preventing reintroduction of malaria in the border area of China. Understanding risk f...

    Authors: Jian-Wei Xu, Dao-Wei Deng, Chun Wei, Xing-Wu Zhou and Jian-Xiong Li
    Citation: Malaria Journal 2022 21:288
  9. Although rapid diagnostic tests (RDTs) play a key role in malaria-control strategies, their efficacy has been threatened by deletion and genetic variability of the genes pfhrp2/3. This study aims to characterize ...

    Authors: Irene Molina - de la Fuente, Mulat Yimar, Luz García, Vicenta González, Arancha Amor, Melaku Anegagrie, Agustín Benito, Javier Martínez, Marta Moreno and Pedro Berzosa
    Citation: Malaria Journal 2022 21:287
  10. Plasmodium falciparum resistance to series of anti-malarial drugs is a major challenge in efforts to control and/or eliminate malaria globally. In 1998, following the widespread of chloroquine (CQ) resistant P. ...

    Authors: Jifar Hassen, Gezahegn Solomon Alemayehu, Hunduma Dinka and Lemu Golassa
    Citation: Malaria Journal 2022 21:286
  11. Severe malaria is a medical emergency. It is a major cause of preventable childhood death in tropical countries. Severe malaria justifies considerable global investment in malaria control and elimination yet, ...

    Authors: Nicholas J. White
    Citation: Malaria Journal 2022 21:284
  12. Quantifying disease costs is critical for policymakers to set priorities, allocate resources, select control and prevention strategies, and evaluate the cost-effectiveness of interventions. Although malaria ca...

    Authors: Mônica V. Andrade, Kenya Noronha, Bernardo P. C. Diniz, Gilvan Guedes, Lucas R. Carvalho, Valéria A. Silva, Júlia A. Calazans, André S. Santos, Daniel N. Silva and Marcia C. Castro
    Citation: Malaria Journal 2022 21:283
  13. Quantitative measurement of Glucose-6-Phosphate Dehydrogenase (G6PD) enzyme activity is critical to decide on appropriate treatment and provision of radical cure regimens for vivax malaria. Biosensors are poin...

    Authors: Bipin Adhikari, Rupam Tripura, Lek Dysoley, James J. Callery, Thomas J. Peto, Chhoeun Heng, Thy Vanda, Ou Simvieng, Sarah Cassidy-Seyoum, Benedikt Ley, Kamala Thriemer, Arjen M. Dondorp and Lorenz von Seidlein
    Citation: Malaria Journal 2022 21:282
  14. Malaria is still a major public health threat in some parts of the world. Many countries are targeting to achieve malaria free status country. This study aimed to determine the sero-prevalence of malaria and t...

    Authors: Siti Fatimah Kader Maideen, Abdul Rashid, Nur Indah Ahmad, Siti Nur Afiqah Zahari and Rukman Awang Hamat
    Citation: Malaria Journal 2022 21:281
  15. Plasmodial species naturally infecting orang-utans, Plasmodium pitheci and Plasmodium silvaticum, have been rarely described and reportedly cause relatively benign infections. Orang-utans at Rescue Rehabilitation...

    Authors: Karmele Llano Sanchez, Alex D. Greenwood, Aileen Nielsen, R. Taufiq P. Nugraha, Wendi Prameswari, Andini Nurillah, Fitria Agustina, Gail Campbell-Smith, Anik Budhi Dharmayanthi, Rahadian Pratama, Indra Exploitasia and J. Kevin Baird
    Citation: Malaria Journal 2022 21:280
  16. Countries in the southern Africa region have set targets for malaria elimination between 2020 and 2030. Malaria vector control is among the key strategies being implemented to achieve this goal. This paper cri...

    Authors: Theresia Estomih Nkya, Ulrike Fillinger, Onyango P. Sangoro, Rose Marubu, Emmanuel Chanda and Clifford Maina Mutero
    Citation: Malaria Journal 2022 21:279
  17. Iron status is considered as a continuum from an iron deficiency with anaemia, without anaemia, varying amounts of stored iron to iron overload. The burden of Plasmodium falciparum infections is typically high am...

    Authors: Peter A. M. Ntenda, Angeziwa C. Chirambo, Owen Nkoka, Walaa M. El-Meidany and Jessy Goupeyou-Youmsi
    Citation: Malaria Journal 2022 21:278
  18. Insecticide resistance is a key barrier to long-term malaria control, and it may be exacerbated by poor agricultural pesticide use. Current practices, however, do not link public health and agricultural pestic...

    Authors: Nancy Stephen Matowo, Marcel Tanner, Benigni Alfred Temba, Marceline Finda, Yeromin Paul Mlacha, Jürg Utzinger and Fredros Oketch Okumu
    Citation: Malaria Journal 2022 21:277
  19. Malaria is one of the prime reasons for medical consultation and the major cause of morbidity and mortality in Mali. To assess and understand the dynamics of social representations of malaria, the anthropologi...

    Authors: Bourema Sissoko, Mohamed Yunus Rafiq, Jiaqi Rosemary Wang and N’bamori dite Naba Sissoko
    Citation: Malaria Journal 2022 21:276
  20. Previous studies have revealed high malaria transmission in Bouaké, Côte d’Ivoire. The sociopolitical crisis in the country and the resulting environmental changes have raised the need to update existing knowl...

    Authors: Florence Fournet, Akre M. Adja, Kouassi A. Adou, Milossé M. C. Dahoui, Baba Coulibaly, Konan F. Assouho, Dounin D. Zoh, Moussa Koné, Aboubacar Koné, Koffi L. Niamien, Sylvie Cornelie, Emmanuel Tia and Nicolas Moiroux
    Citation: Malaria Journal 2022 21:275
  21. Evidence suggests that pre-referral Rectal Artesunate (RAS) can be a life-saving intervention for severe malaria in remote settings in Africa. Recognition of danger signs indicative of severe malaria is critic...

    Authors: Jean Okitawutshu, Aita Signorell, Jean-Claude Kalenga, Eric Mukomena, Giulia Delvento, Christian Burri, Fatou Mwaluke, Valentina Buj, Moulaye Sangare, Sylvie Luketa, Nina Brunner, Tristan Lee, Manuel Hetzel, Christian Lengeler and Antoinette Tshefu
    Citation: Malaria Journal 2022 21:274
  22. Every evening, chimpanzees (Pan troglodytes) build a sleeping platform so called “nest” by intertwining branches of tree. Most of chimpanzees’ communities studied have a preference for tree species in which they ...

    Authors: Camille Lacroux, Emmanuelle Pouydebat, Marie Rossignol, Sophie Durand, Alfred Aleeje, Edward Asalu, Fabrice Chandre and Sabrina Krief
    Citation: Malaria Journal 2022 21:271
  23. Although IPTp-SP is a lifesaving World Health Organization (WHO) recommended preventive intervention for pregnant women in malaria-endemic regions, IPTp-SP uptake in the Northern region of Ghana is much lower ...

    Authors: Abdul Gafaru Mohammed, Dwomoh Duah, Ernest Kenu, Justice Nonvignon, Alex Manu and Harriet Affran Bonful
    Citation: Malaria Journal 2022 21:273
  24. Long-lasting insecticidal nets (LLINs) have been the primary vector control strategy until indoor residual spraying (IRS) was added in Homa Bay and Migori Counties in western Kenya. The objective of this study...

    Authors: Collince J. Omondi, Wilfred O. Otambo, David Odongo, Kevin O. Ochwedo, Antony Otieno, Shirley A. Onyango, Pauline Orondo, Benyl M. Ondeto, Ming-Chieh Lee, Daibin Zhong, James W. Kazura, Andrew K. Githeko and Guiyun Yan
    Citation: Malaria Journal 2022 21:272
  25. Malaria is a major public health concern in The Gambia. There is limited data on the clinical manifestation and outcome of severe malaria in adult patients in The Gambia. The study therefore assessed the clini...

    Authors: Sheikh Omar Bittaye, Abubacarr Jagne, Lamin ES Jaiteh, Behzad Nadjm, Alfred Amambua-Ngwa, Abdul Karim Sesay, Yankuba Singhateh, Emmanuel Effa, Ousman Nyan and Ramou Njie
    Citation: Malaria Journal 2022 21:270
  26. In sub-Saharan Africa, malaria is the common diagnosis for febrile illness and related clinical features, resulting in the under-diagnosis of other aetiologies, such as arboviruses and Rickettsia. While these may...

    Authors: Tatenda Chiuya, Jandouwe Villinger, Laura C. Falzon, Lorren Alumasa, Fredrick Amanya, Armanda D. S. Bastos, Eric M. Fèvre and Daniel K. Masiga
    Citation: Malaria Journal 2022 21:268
  27. Plasmodium falciparum is the most serious, genetically most complex and fastest-evolving malaria parasite. Information on genetic diversity of this parasite would guide policy decision and malaria elimination end...

    Authors: Abeba Gebretsadik Reda, Alebachew Messele, Hussein Mohammed, Ashenafi Assefa, Lemu Golassa and Hassen Mamo
    Citation: Malaria Journal 2022 21:267
  28. Over the last two decades, the scale-up of vector control and changes in the first-line anti-malarial, from chloroquine (CQ) to sulfadoxine-pyrimethamine (SP) and then to artemether-lumefantrine (AL), have res...

    Authors: Zhiyong Zhou, John E. Gimnig, Sheila B. Sergent, Ying Liu, Bernard Abong’o, Kephas Otieno, Winnie Chebore, Monica P. Shah, John Williamson, Feiko O. ter Kuile, Mary J. Hamel, Simon Kariuki, Meghna Desai, Aaron M. Samuels, Edward D. Walker and Ya Ping Shi
    Citation: Malaria Journal 2022 21:265
  29. Sporozoites isolated from the salivary glands of Plasmodium-infected mosquitoes are a prerequisite for several basic and pre-clinical applications. Although salivary glands are pooled to maximize sporozoite recov...

    Authors: Ashutosh K. Pathak, Justine C. Shiau, Blandine Franke-Fayard, Lisa M. Shollenberger, Donald A. Harn, Dennis E. Kyle and Courtney C. Murdock
    Citation: Malaria Journal 2022 21:264
  30. Sri Lanka, an island nation, has eliminated endemic malaria transmission. Maintaining elimination in the continued presence of vectors requires vigilance in screening people travelling from high malaria-risk a...

    Authors: Deepika Fernando, Priyaleela Thota, Saveen Semege, Rahuman Booso, David Bell, Kumudunayana T. de A. W. Gunasekera and Prasad Ranaweera
    Citation: Malaria Journal 2022 21:263
  31. Malaria is extremely common in Ethiopia, and it is one of the country's most serious public health and economic problems. Traditional medicines have long been utilized in Ethiopia by people of various ethnic g...

    Authors: Gashaw Nigussie and Minychel Wale
    Citation: Malaria Journal 2022 21:262
  32. Rapid diagnostic tests (RDT) for malaria are the primary tool for malaria diagnosis in sub-Saharan Africa but the utility of the most commonly used histidine-rich protein 2 (HRP2) antigen-based tests is limite...

    Authors: Emily Lynch, Tomas O. Jensen, Bachir Assao, Menard Chihana, Thadeous Turuho, Dan Nyehangane, John B. Manyok, Harriet Pasquale, Nimol Khim, Benoit Witkowski and Matthew E. Coldiron
    Citation: Malaria Journal 2022 21:261
  33. Glucose-6-phosphate dehydrogenase (G6PD) is cytosolic enzyme, which has a vital role for the integrity and functioning of red blood cells. Lower activity of this enzyme leads to the occurrence of acute haemoly...

    Authors: Tassew Tefera Shenkutie, Desalegn Nega, Asrat Hailu, Daniel Kepple, Logan Witherspoon, Eugenia Lo, Meshesha Tsigie Negash, Aderaw Adamu, Shewayiref Geremew Gebremichael, Bokretsion Gidey, Geremew Tasew, Sindew M. Feleke and Tadesse Kebede
    Citation: Malaria Journal 2022 21:260
  34. Anti-malarial resistance remains an important public health challenge in Cambodia. The effectiveness of three therapies for uncomplicated falciparum malaria was evaluated in Oddar Meanchey province in Northern...

    Authors: Dysoley Lek, Agus Rachmat, Dustin Harrison, Geoffrey Chin, Suwanna Chaoratanakawee, David Saunders, Didier Menard and William O. Rogers
    Citation: Malaria Journal 2022 21:259
  35. Continuous vector surveillance and sustainable interventions are mandatory in order to prevent anopheline proliferation (or spread to new areas) and interrupt malaria transmission. Anopheline abundance and ric...

    Authors: Anne Caroline Alves Meireles, Lucas Rosendo da Silva, Marlon Ferreira Simplício, Alzemar Alves de Lima, Flávia Geovana Fontineles Rios, Carla Augusta de Menezes, Luiz Henrique Maciel Feitoza and Genimar Rebouças Julião
    Citation: Malaria Journal 2022 21:258
  36. Malaria represents one of the most important imported tropical infectious diseases in European travellers. The objective of the study was to identify changes in the epidemiological features of imported malaria...

    Authors: Milan Trojánek, Vyacheslav Grebenyuk, Lenka Richterová, Ivana Zicklerová, Eva Nohýnková, Zdenka Manďáková, Jakub Kantor, Hana Roháčová and František Stejskal
    Citation: Malaria Journal 2022 21:257
  37. Artesunate is recommended by the World Health Organization (WHO) for parenteral treatment of severe Plasmodium falciparum malaria. However, artesunate is inherently unstable in an aqueous solution and hydrolyses ...

    Authors: Fanta Gashe, Evelien Wynendaele, Bart De Spiegeleer and Sultan Suleman
    Citation: Malaria Journal 2022 21:256
  38. Circulating myeloid-derived-suppressor-cells (MDSC) with immunosuppressive function are increased in human experimental Plasmodium falciparum infection, but have not been studied in clinical malaria.

    Authors: Leo Leonardo, Enny Kenangalem, Jeanne R. Poespoprodjo, Rintis Noviyanti, Ric N. Price, Nicholas M. Anstey, Gabriela Minigo and Steven Kho
    Citation: Malaria Journal 2022 21:255
  39. South Africa has set a mandate to eliminate local malaria transmission by 2023. In pursuit of this objective a Sterile Insect Technique programme targeting the main vector Anopheles arabiensis is currently under ...

    Authors: Nonhlanhla L. Ntoyi, Thabo Mashatola, Jérémy Bouyer, Carina Kraupa, Hamidou Maiga, Wadaka Mamai, Nanwintoum S. Bimbile-Somda, Thomas Wallner, Danilo O. Carvalho, Givemore Munhenga and Hanano Yamada
    Citation: Malaria Journal 2022 21:254
  40. The Democratic Republic of the Congo (DRC) organized a first mass distribution campaign of long-lasting insecticidal nets (LLINs) with digitalized data management with coordinated support from the Ministry of ...

    Authors: Joris Losimba Likwela, Phillipe Lukanu Ngwala, Albert Kalonji Ntumba, Deogratias Cibinda Ntale, Eric Mukomena Sompwe, Godé Kanyeba Mpiana, Joseph Kalonji Tshula, Tathy Kalonda Likwela, Patrick Kanku-Ka-Munabe, Adrien N.’siala Kumbi, Gilbert Kulimushi Ndahambara, Helen Cibinda Ntale, Michele Luntadila Kiamenga, Jules Kabongo Njila, Ghislain Makhan Yav, Didier Gasigwa Baneti…
    Citation: Malaria Journal 2022 21:253
  41. Simple and accurate diagnosis is a key component of malaria control programmes. Microscopy is the current gold standard, however it requires extensive training and the results largely rely on the skill of the ...

    Authors: Wataru Kagaya, Ikki Takehara, Kyoko Kurihara, Michael Maina, Chim W. Chan, Gordon Okomo, James Kongere, Jesse Gitaka and Akira Kaneko
    Citation: Malaria Journal 2022 21:252
  42. The ABO blood groups consist of A, B, and H carbohydrate antigens, which regulate protein activities during malaria infection in humans. Understanding the interplay between the malaria parasite and blood group...

    Authors: Redemptah Yeda, Charles Okudo, Eunice Owiti, Gladys Biwot, Cliff Momanyi, Winnie Korir, Thoya Mitsanze, Caroline Tegerei, Dennis Juma, Benjamin Opot, Edwin Mwakio, Gladys Chemwor, Raphael Okoth, Douglas O. Ochora, Agnes C. Cheruiyot, Amanda Roth…
    Citation: Malaria Journal 2022 21:251
  43. Glucose 6-phosphate dehydrogenase (G6PD) and pyruvate kinase (PKLR) deficiencies are common causes of erythrocyte haemolysis in the presence of antimalarial drugs such as primaquine and tafenoquine. The presen...

    Authors: Punchalee Mungkalasut, Patcharakorn Kiatamornrak, Watcharapong Jugnam-Ang, Srivicha Krudsood, Poonlarp Cheepsunthorn and Chalisa Louicharoen Cheepsunthorn
    Citation: Malaria Journal 2022 21:250
  44. Plasmodium parasites that cause bird malaria occur in all continents except Antarctica and are primarily transmitted by mosquitoes in the genus Culex. Culex quinquefasciatus, the mosquito vector of avian malaria ...

    Authors: Francisco C. Ferreira, Elin Videvall, Christa M. Seidl, Nicole E. Wagner, A. Marm Kilpatrick, Robert C. Fleischer and Dina M. Fonseca
    Citation: Malaria Journal 2022 21:249
  45. Plasmodium falciparum malaria is recognized as a major global public health problem. The malaria vaccine was important because the case fatality rate of falciparum malaria was high. Plasmodium falciparum circumsp...

    Authors: Zhi-quan He, Qun-qun Zhang, Dan Wang, Ya-bo Hu, Rui-min Zhou, Dan Qian, Cheng-yun Yang, De-ling Lu, Su-hua Li, Ying Liu and Hong-wei Zhang
    Citation: Malaria Journal 2022 21:248
  46. Plasmodium falciparum (Pf) sporozoite (SPZ) vaccines are the only candidate malaria vaccines that induce > 90% vaccine efficacy (VE) against controlled human malaria infection and the only malaria vaccines to ha...

    Authors: Sumana Chakravarty, Melanie J. Shears, Eric R. James, Urvashi Rai, Natasha KC, Solomon Conteh, Lynn E. Lambert, Patrick E. Duffy, Sean C. Murphy and Stephen L. Hoffman
    Citation: Malaria Journal 2022 21:247

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