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  1. Content type: Research

    Today, the development of new and well-tolerated anti-malarial drugs is strongly justified by the emergence of Plasmodium falciparum resistance. In 2014–2015, a phase 2b clinical study was conducted to evaluate t...

    Authors: Didier Leroy, Fiona Macintyre, Yeka Adoke, Serge Ouoba, Aissata Barry, Ghyslain Mombo-Ngoma, Jacques Mari Ndong Ngomo, Rosauro Varo, Yannelle Dossou, Antoinette Kitoto Tshefu, Tran Thanh Duong, Bui Quang Phuc, Bart Laurijssens, Roland Klopper, Nimol Khim, Eric Legrand…

    Citation: Malaria Journal 2019 18:126

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  2. Content type: Correction

    Following publication of the original article [1], the corresponding author flagged that the particle ‘de’ in their name had been placed incorrectly.

    Authors: Jessica de Oliveira Sousa, Bernardino Claudio de Albuquerque, José Rodrigues Coura and Martha Cecilia Suárez-Mutis

    Citation: Malaria Journal 2019 18:125

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    The original article was published in Malaria Journal 2019 18:100

  3. Content type: Research

    In low malaria transmission areas, many people acquire multiple malaria infections within a single season. This study aimed to describe the pattern and epidemiological profile of malaria recurrence in a hypoen...

    Authors: Saranath Lawpoolsri, Jetsumon Sattabongkot, Jeeraphat Sirichaisinthop, Liwang Cui, Kirakorn Kiattibutr, Nattawan Rachaphaew, Kritsana Suk-uam, Amnat Khamsiriwatchara and Jaranit Kaewkungwal

    Citation: Malaria Journal 2019 18:124

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  4. Content type: Commentary

    Delayed haemolysis is a frequent adverse event after treatment with artesunate (AS). Removing once-infected “pitted” erythrocytes by the spleen is the most accepted mechanism of haemolysis in these cases. Howe...

    Authors: Daniel Camprubí, Arturo Pereira, Natalia Rodriguez-Valero, Alex Almuedo, Rosauro Varo, Climent Casals-Pascual, Quique Bassat, Denis Malvy and Jose Muñoz

    Citation: Malaria Journal 2019 18:123

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  5. Content type: Research

    To reduce the malaria burden in Nigeria, the National Malaria Strategic Plan (NMSP) 2014‒2020 calls for the scale-up of prevention and treatment interventions, including social and behaviour change (SBC). SBC ...

    Authors: Kirsten Zalisk, Samantha Herrera, Uwem Inyang, Audu Bala Mohammed, Perpetua Uhomoibhi and Yazoumé Yé

    Citation: Malaria Journal 2019 18:121

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  6. Content type: Research

    Mosquitoes of the Anopheles gambiae complex are the main malaria vectors worldwide. Due to the lack of a vaccine to prevent malaria, the principal way to reduce the impact of this disease relies on the use of che...

    Authors: Derciliano Lopes da Cruz, Marcelo Henrique Santos Paiva, Duschinka Ribeiro Duarte Guedes, Joana Alves, Lara Ferrero Gómez and Constância Flávia Junqueira Ayres

    Citation: Malaria Journal 2019 18:120

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  7. Content type: Research

    Traditional medicinal plants are one of the potential sources of anti-malarial drugs and there is an increasing interest in the use and development of traditional herbal remedies for the treatment of malaria a...

    Authors: Prisca A. Kweyamba, Denis Zofou, Noella Efange, Jules-Clement N. Assob, Jovin Kitau and Mramba Nyindo

    Citation: Malaria Journal 2019 18:119

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  8. Content type: Research

    Malaria is still an important parasitic infectious disease that affecting poor and vulnerable communities in many developing countries, including Indonesia. During the period of 2010–2017, there have been appr...

    Authors: Pandji Wibawa Dhewantara, Mara Ipa and Mutiara Widawati

    Citation: Malaria Journal 2019 18:118

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  9. Content type: Research

    Brazilian malaria control programmes successfully reduced the incidence and mortality rates from 2005 to 2016. Since 2017, increased malaria has been reported across the Amazon. Few field studies focus on the ...

    Authors: Maria Anice M. Sallum, Jan E. Conn, Eduardo S. Bergo, Gabriel Z. Laporta, Leonardo S. M. Chaves, Sara A. Bickersmith, Tatiane M. P. de Oliveira, Elder Augusto G. Figueira, Gilberto Moresco, Lêuda Olívêr, Claudio J. Struchiner, Laith Yakob and Eduardo Massad

    Citation: Malaria Journal 2019 18:117

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  10. Content type: Research

    Malaria remains a global public health problem responsible for 445,000 deaths in 2016. While microscopy remains the mainstay of malaria diagnosis, highly sensitive molecular methods for detection of low-grade ...

    Authors: Bryan Grabias, Edward Essuman, Isabella A. Quakyi and Sanjai Kumar

    Citation: Malaria Journal 2019 18:116

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  11. Content type: Research

    In Mozambique, the prevalence of malaria in children under 5 years of age is among the highest in the world, but limited data exist on determinants of care-seeking behaviour for malaria. This study aimed at de...

    Authors: Annette Cassy, Abuchahama Saifodine, Baltazar Candrinho, Maria do Rosário Martins, Saraiva da Cunha, Filomena Martins Pereira and Eduardo Samo Gudo

    Citation: Malaria Journal 2019 18:115

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  12. Content type: Research

    Mutations in Pfkelch13 and Pfplasmepsin2/3 gene amplification are well-established markers for artemisinin and piperaquine resistance in Plasmodium falciparum, a widespread problem in the Greater Mekong Subregion...

    Authors: Jureeporn Duanguppama, Vivek Bhakta Mathema, Rupam Tripura, Nicholas P. J. Day, Mayfong Maxay, Chea Nguon, Lorenz von Seidlein, Mehul Dhorda, Thomas J. Peto, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong

    Citation: Malaria Journal 2019 18:114

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  13. Content type: Research

    In the context of widespread mosquito resistance to currently available pesticides, novel, precise genetic vector control methods aimed at population suppression or trait replacement are a potentially powerful...

    Authors: Patric Stephane Epopa, Catherine Matilda Collins, Ace North, Abdoul Azize Millogo, Mark Quentin Benedict, Frederic Tripet and Abdoulaye Diabate

    Citation: Malaria Journal 2019 18:113

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  14. Content type: Research

    Physiological characteristics (age and blood feeding status) of malaria vectors can influence their susceptibility to the current vector control tools that target their feeding and resting behaviour. To ensure...

    Authors: Maxwell G. Machani, Eric Ochomo, David Sang, Mariangela Bonizzoni, Guofa Zhou, Andrew K. Githeko, Guiyun Yan and Yaw A. Afrane

    Citation: Malaria Journal 2019 18:112

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  15. Content type: Research

    Primaquine (PQ) prevents relapses of vivax malaria but may induce severe haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. Data on the safety of primaquine in infants are limited.

    Authors: Agus Setyadi, Eggi Arguni, Enny Kenangalem, Afdhal Hasanuddin, Daniel A. Lampah, Kamala Thriemer, Nicholas M. Anstey, Paulus Sugiarto, Julie A. Simpson, Ric N. Price, Nicholas M. Douglas and Jeanne R. Poespoprodjo

    Citation: Malaria Journal 2019 18:111

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  16. Content type: Research

    The mosquito Anopheles (Kerteszia) cruzii is the main vector of human and simian malaria in the Atlantic Forest. This species is usually abundant in the forests where it occurs, preferring to live and feed on can...

    Authors: Antônio Ralph Medeiros-Sousa, Rafael de Oliveira Christe, Ana Maria Ribeiro de Castro Duarte, Luis Filipe Mucci, Walter Ceretti-Junior and Mauro Toledo Marrelli

    Citation: Malaria Journal 2019 18:110

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  17. Content type: Research

    As part of ongoing co-surveillance of intestinal schistosomiasis and malaria in Ugandan school children, a non-invasive detection method for amplification of Plasmodium DNA using real-time (rt)PCR analysis of eth...

    Authors: Hajri Al-Shehri, B. Joanne Power, John Archer, Alice Cousins, Aaron Atuhaire, Moses Adriko, Moses Arinaitwe, Abdullah D. Alanazi, E. James LaCourse, Narcis B. Kabatereine and J. Russell Stothard

    Citation: Malaria Journal 2019 18:109

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  18. Content type: Research

    The South African province of KwaZulu-Natal is rapidly approaching elimination status for malaria with a steady decline in local cases. With the possibility of achieving elimination in reach, the KZN malaria c...

    Authors: Ryleen Balawanth, Inessa Ba, Bheki Qwabe, Laura Gast, Rajendra Maharaj, Jaishree Raman, Rebecca Graffy, Mbavhalelo Shandukani and Devanand Moonasar

    Citation: Malaria Journal 2019 18:108

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  19. Content type: Research

    Historically, malaria had been a widespread disease in China. A national plan was launched in China in 2010, aiming to eliminate malaria by 2020. In 2017, no indigenous cases of malaria were detected in China ...

    Authors: Shengjie Lai, Junling Sun, Nick W. Ruktanonchai, Sheng Zhou, Jianxing Yu, Isobel Routledge, Liping Wang, Yaming Zheng, Andrew J. Tatem and Zhongjie Li

    Citation: Malaria Journal 2019 18:107

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  20. Content type: Research

    Following the scale-up of intervention efforts, malaria burden has decreased dramatically in Solomon Islands (SI). Submicroscopic and asymptomatic Plasmodium vivax infections are now the major challenge for malar...

    Authors: Yi Wan Quah, Andreea Waltmann, Stephan Karl, Michael T. White, Ventis Vahi, Andrew Darcy, Freda Pitakaka, Maxine Whittaker, Daniel J. Tisch, Alyssa Barry, Celine Barnadas, James Kazura and Ivo Mueller

    Citation: Malaria Journal 2019 18:106

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  21. Content type: Research

    The World Health Organization (WHO) recommendation of treating uncomplicated malaria during the second and third trimester of pregnancy with an artemisinin-based combination therapy (ACT) has already been impl...

    Authors: Michael Nambozi, Halidou Tinto, Victor Mwapasa, Harry Tagbor, Jean-Bertin Bukasa Kabuya, Sebastian Hachizovu, Maminata Traoré, Innocent Valea, Marc Christian Tahita, Gifty Ampofo, Jozefien Buyze, Raffaella Ravinetto, Diana Arango, Kamala Thriemer, Modest Mulenga, Jean-Pierre van Geertruyden…

    Citation: Malaria Journal 2019 18:105

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  22. Content type: Research

    The Belgian Reference Laboratory for Plasmodium offers a free-of-charge reference testing of malaria-positive or doubtful samples to clinical laboratories.

    Authors: Laura Loomans, Anali Conesa Botella, Agnes D’hondt, Jacob Verschueren, Dorien Van den Bossche, Marjan Van Esbroeck and Jan Jacobs

    Citation: Malaria Journal 2019 18:104

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  23. Content type: Research

    Malaria is a leading cause of illness and death in Nigeria, but access of poor people to quality anti-malarial services remains low especially in the rural areas. Patent and proprietary medicine vendors (PPMVs...

    Authors: Oladimeji Oladepo, Abisoye S. Oyeyemi, Musibau A. Titiloye, Adedayo O. Adeyemi, Sarah M. Burnett, Iorwakwagh Apera, Opeyemi Oladunni and Michael Alliu

    Citation: Malaria Journal 2019 18:103

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  24. Content type: Research

    Malaria still claims substantial lives of individuals in Tanzania. Insecticide-treated nets (ITNs) and indoor residual spray (IRS) are used as major malaria vector control tools. These tools are facing great c...

    Authors: Deokary Joseph Matiya, Anitha B. Philbert, Winifrida Kidima and Johnson J. Matowo

    Citation: Malaria Journal 2019 18:102

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  25. Content type: Research

    Sulfadoxine–pyrimethamine (SP) is recommended for intermittent preventive treatment of malaria in Africa. However, increasing SP resistance (SPR) affects the therapeutic efficacy of the SP. As molecular markers,

    Authors: Tingting Jiang, Jiangtao Chen, Hongxia Fu, Kai Wu, Yi Yao, Juan Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko Ondo Obono, Weixing Du, Huabing Tan, Min Lin and Jian Li

    Citation: Malaria Journal 2019 18:101

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  26. Content type: Research

    Long-lasting insecticidal nets (LLINs) are one of the main vector control strategies recommended by the World Health Organization for the control and elimination of malaria. This study aimed to evaluate the us...

    Authors: Jessica de Oliveira Sousa, Bernardino Claudio de Albuquerque, José Rodrigues Coura and Martha Cecilia Suárez-Mutis

    Citation: Malaria Journal 2019 18:100

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    The Correction to this article has been published in Malaria Journal 2019 18:125

  27. Content type: Research

    The Tanzanian National Malaria Control Programme (NMCP) and its partners have been implementing regular therapeutic efficacy studies (TES) to monitor the performance of different drugs used or with potential u...

    Authors: Celine I. Mandara, Filbert Francis, Mercy G. Chiduo, Billy Ngasala, Renata Mandike, Sigsbert Mkude, Frank Chacky, Fabrizio Molteni, Ritha Njau, Ally Mohamed, Marian Warsame and Deus S. Ishengoma

    Citation: Malaria Journal 2019 18:99

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  28. Content type: Research

    Microscopic detection of malaria parasites is the standard method for clinical diagnosis of malaria in Brazil. However, malaria epidemiological surveillance studies specifically aimed at the detection of low-d...

    Authors: Heather M. Kudyba, Jaime Louzada, Dragan Ljolje, Karl A. Kudyba, Vasant Muralidharan, Joseli Oliveira-Ferreira and Naomi W. Lucchi

    Citation: Malaria Journal 2019 18:98

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  29. Content type: Research

    Lactic acidosis with an elevated lactate–pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the ...

    Authors: Hugh W. Kingston, Aniruddha Ghose, Voravut Rungpradubvong, M. Trent Herdman, Katherine Plewes, Haruhiko Ishioka, Stije J. Leopold, Richard J. Maude, Benjamas Intharabut, Sanjib Mohanty, Nicholas P. J. Day, Nicholas J. White, Md Amir Hossain, Nicholas M. Anstey and Arjen M. Dondorp

    Citation: Malaria Journal 2019 18:97

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  30. Content type: Research

    Community composition of Anopheles mosquitoes, and their host-seeking and peridomestic behaviour, are important factors affecting malaria transmission. In this study, barrier screen sampling was used to investiga...

    Authors: John B. Keven, Michelle Katusele, Rebecca Vinit, Gussy Koimbu, Naomi Vincent, Edward K. Thomsen, Stephan Karl, Lisa J. Reimer and Edward D. Walker

    Citation: Malaria Journal 2019 18:96

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  31. Content type: Research

    Malaria control in Panama is problematic due to the high diversity of morphologically similar Anopheles mosquito species, which makes identification of vectors of human Plasmodium challenging. Strategies by Panam...

    Authors: Jose R. Loaiza, Alejandro Almanza, Juan C. Rojas, Luis Mejía, Norma D. Cervantes, Javier E. Sanchez-Galan, Fernando Merchán, Arnaud Grillet, Matthew J. Miller, Luis F. De León and Rolando A. Gittens

    Citation: Malaria Journal 2019 18:95

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  32. Content type: Review

    Great progress has been made in recent years to reduce the high level of suffering caused by malaria worldwide. Notably, the use of insecticide-treated mosquito nets for malaria prevention and the use of artem...

    Authors: Edwin G. Tse, Marat Korsik and Matthew H. Todd

    Citation: Malaria Journal 2019 18:93

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  33. Content type: Research

    Adequate knowledge of malaria prevention and control can help in reducing the growing burden of malaria among vulnerable groups, particularly pregnant women and children aged under 5 years living in malaria en...

    Authors: Kelechi Elizabeth Oladimeji, Joyce Mahlako Tsoka-Gwegweni, Elizabeth Ojewole and Samuel Tassi Yunga

    Citation: Malaria Journal 2019 18:92

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  34. Content type: Research

    In April 2017, Suriname’s Ministry of Health alerted French Guiana’s Regional Health Agency (RHA) about an increase of imported malaria cases among people coming from an illegal gold mining site called Sophie, in...

    Authors: Maylis Douine, Alice Sanna, Helene Hiwat, Sébastien Briolant, Mathieu Nacher, Didier Belleoud, François Michel Le Tourneau, Hervé Bogreau and Franck De Laval

    Citation: Malaria Journal 2019 18:91

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  35. Content type: Meeting report

    The Demographic and Health Surveys (DHS) Program has supported three household Malaria Indicator Surveys (MIS) in Madagascar. The results of 13 key malaria indicators from these surveys have been mapped as con...

    Authors: Rosalind E. Howes, Kaleem Hawa, Voahangy Fanomezana Andriamamonjy, Thierry Franchard, Raharizo Miarimbola, Sedera Aurélien Mioramalala, Jean Florent Rafamatanantsoa, Mirana Ando Mbolatiana Rahantamalala, Solo Harimalala Rajaobary, Hariniaina David Gaël Rajaonera, Andrianiaina Parfait Rakotonindrainy, Clairaut Rakotoson Andrianjatonavalona, Dina Ny Aina Liantsoa Randriamiarinjatovo, Faratiana Michèle Randrianasolo, Rado Malalatiana Ramasy Razafindratovo, Masiarivony Ravaoarimanga…

    Citation: Malaria Journal 2019 18:90

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  36. Content type: Research

    Malaria is one of the most prevalent tropical infectious diseases. Since recently cases of artemisinin resistance were reported, novel anti-malarial drugs are required which differ from artemisinins in structu...

    Authors: Andreas Masch, Abed Nasereddin, Arne Alder, Megan J. Bird, Sandra I. Schweda, Lutz Preu, Christian Doerig, Ron Dzikowski, Tim W. Gilberger and Conrad Kunick

    Citation: Malaria Journal 2019 18:89

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  37. Content type: Research

    The World Health Organization recommends regular therapeutic efficacy studies (TES) to monitor the performance of first and second-line anti-malarials. In 2016, efficacy and safety of artemether-lumefantrine (...

    Authors: Deus S. Ishengoma, Celine I. Mandara, Filbert Francis, Eldin Talundzic, Naomi W. Lucchi, Billy Ngasala, Abdunoor M. Kabanywanyi, Muhidin K. Mahende, Erasmus Kamugisha, Reginald A. Kavishe, Florida Muro, Ally Mohamed, Renata Mandike, Sigsbert Mkude, Frank Chacky, Lynn Paxton…

    Citation: Malaria Journal 2019 18:88

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  38. Content type: Research

    Push–pull strategies have been proposed as options to complement primary malaria prevention tools, indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs), by targeting particularly ea...

    Authors: Arnold S. Mmbando, Elis P. A. Batista, Masoud Kilalangongono, Marceline F. Finda, Emmanuel P. Mwanga, Emmanuel W. Kaindoa, Khamis Kifungo, Rukiyah M. Njalambaha, Halfan S. Ngowo, Alvaro E. Eiras and Fredros O. Okumu

    Citation: Malaria Journal 2019 18:87

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  39. Content type: Research

    The malarial parasite Plasmodium falciparum is an auxotroph for purines, which are required for nucleic acid synthesis during the intra-erythrocytic developmental cycle (IDC) of the parasite. The capabilities of ...

    Authors: Shivendra G. Tewari, Krithika Rajaram, Patric Schyman, Russell Swift, Jaques Reifman, Sean T. Prigge and Anders Wallqvist

    Citation: Malaria Journal 2019 18:86

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  40. Content type: Methodology

    Large-scale surveillance of mosquito populations is crucial to assess the intensity of vector-borne disease transmission and the impact of control interventions. However, there is a lack of accurate, cost-effe...

    Authors: Marta F. Maia, Melissa Kapulu, Michelle Muthui, Martin G. Wagah, Heather M. Ferguson, Floyd E. Dowell, Francesco Baldini and Lisa Ranford-Cartwright

    Citation: Malaria Journal 2019 18:85

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    The Correction to this article has been published in Malaria Journal 2019 18:137

  41. Content type: Research

    Current World Health Organization guidelines for conducting anti-malarial drug efficacy clinical trials recommend genotyping Plasmodium falciparum genes msp1 and msp2 to distinguish recrudescence from reinfection...

    Authors: Joseph Fulakeza, Sarah McNitt, Jimmy Vareta, Alex Saidi, Godfrey Mvula, Terrie Taylor, Don P. Mathanga, Dylan S. Small, Jacek Skarbinski, Julie R. Gutman and Karl Seydel

    Citation: Malaria Journal 2019 18:84

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  42. Content type: Research

    Mosquito biting rates and host preferences are crucial determinants of human exposure to vector-borne diseases and the impact of vector control measures. The human landing catch (HLC) is a gold standard method...

    Authors: Felician C. Meza, Katharina S. Kreppel, Deodatus F. Maliti, Amos T. Mlwale, Nosrat Mirzai, Gerry F. Killeen, Heather M. Ferguson and Nicodem J. Govella

    Citation: Malaria Journal 2019 18:83

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  43. Content type: Research

    Bayesian methods have been used to generate country-level and global maps of malaria prevalence. With increasing availability of detailed malaria surveillance data, these methodologies can also be used to ide...

    Authors: Punam Amratia, Paul Psychas, Benjamin Abuaku, Collins Ahorlu, Justin Millar, Samuel Oppong, Kwadwo Koram and Denis Valle

    Citation: Malaria Journal 2019 18:81

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  44. Content type: Research

    Comprehensive reports of malaria in Menoreh Hills, Central Java, Indonesia, a unique district cross-boundaries area under three districts and two provinces have been published previously. However, no study was...

    Authors: Dwi Sarwani Sri Rejeki, Anis Fuad, Barandi Sapta Widartono, E. Elsa Herdiana Murhandarwati and Hari Kusnanto

    Citation: Malaria Journal 2019 18:80

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  45. Content type: Research

    Insecticide-treated bed nets (ITNs) help to control malaria by mechanically impeding the biting of mosquitoes, by repelling and irritating them and by killing them. In contrast to spatial repellency, irritancy...

    Authors: Kevin Thiévent, Gaël Hauser, Obada Elaian and Jacob C. Koella

    Citation: Malaria Journal 2019 18:79

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  46. Content type: Research

    The Plasmodium falciparum histidine-rich protein II (PfHRP2) is a common biomarker used in malaria rapid diagnostic tests (RDTs), but can persist in the blood for up to 40 days following curative treatment. The p...

    Authors: Kristin E. Poti, Amanda E. Balaban, Priya Pal, Tamaki Kobayashi, Daniel E. Goldberg, Photini Sinnis and David J. Sullivan

    Citation: Malaria Journal 2019 18:78

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  47. Content type: Research

    Immunity that limits malarial disease is acquired over time, but adults living in endemic areas continue to become infected and can require treatment for clinical illness. Gamma delta (γδ) T cells, particularl...

    Authors: Hama Diallo, Abdoulaye Katile, Jennifer L. Kwan, Mahamadou S. Sissoko, Sara A. Healy, Ogobara K. Doumbo, Patrick E. Duffy and Irfan Zaidi

    Citation: Malaria Journal 2019 18:69

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