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  1. Research

    A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical samples

    VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family, mediates the binding of P. falciparum-infected erythrocytes to chondroitin sulfate A, a surface-associated molecule e...

    Antoine Dara, Mark A. Travassos, Matthew Adams, Sarah Schaffer DeRoo, Elliott F. Drábek, Sonia Agrawal, Miriam K. Laufer, Christopher V. Plowe and Joana C. Silva

    Malaria Journal 2017 16:343

    Published on: 17 August 2017

  2. Research

    Evaluation of piperonyl butoxide in enhancing the efficacy of pyrethroid insecticides against resistant Anopheles gambiae s.l. in Ghana

    Malaria vector control methods involving the use of pyrethroids remain the strategies being used against malaria vectors in Ghana. These methods include the use of long-lasting insecticidal nets and indoor res...

    Samuel K. Dadzie, Joseph Chabi, Andy Asafu-Adjaye, Otubea Owusu-Akrofi, Aba Baffoe-Wilmot, Keziah Malm, Constance Bart-Plange, Sylvester Coleman, Maxwell A. Appawu and Daniel A. Boakye

    Malaria Journal 2017 16:342

    Published on: 17 August 2017

  3. Research

    Do the venous blood samples replicate malaria parasite densities found in capillary blood? A field study performed in naturally-infected asymptomatic children in Cameroon

    The measure of new drug- or vaccine-based approaches for malaria control is based on direct membrane feeding assays (DMFAs) where gametocyte-infected blood samples are offered to mosquitoes through an artifici...

    Maurice M. Sandeu, Albert N. Bayibéki, Majoline T. Tchioffo, Luc Abate, Geoffrey Gimonneau, Parfait H. Awono-Ambéné, Sandrine E. Nsango, Diadier Diallo, Antoine Berry, Gaétan Texier and Isabelle Morlais

    Malaria Journal 2017 16:345

    Published on: 17 August 2017

  4. Research

    Completeness of malaria indicator data reporting via the District Health Information Software 2 in Kenya, 2011–2015

    Health facility-based data reported through routine health information systems form the primary data source for programmatic monitoring and evaluation in most developing countries. The adoption of District Hea...

    Sophie Githinji, Robinson Oyando, Josephine Malinga, Waqo Ejersa, David Soti, Josea Rono, Robert W. Snow, Ann M. Buff and Abdisalan M. Noor

    Malaria Journal 2017 16:344

    Published on: 17 August 2017

  5. Research

    Modelling the benefits of long-acting or transmission-blocking drugs for reducing Plasmodium falciparum transmission by case management or by mass treatment

    Anti-malarial drugs are an important tool for malaria control and elimination. Alongside their direct benefit in the treatment of disease, drug use has a community-level effect, clearing the reservoir of infec...

    Michael T. Bretscher, Jamie T. Griffin, Azra C. Ghani and Lucy C. Okell

    Malaria Journal 2017 16:341

    Published on: 16 August 2017

  6. Research

    Which intervention is better for malaria vector control: insecticide mixture long-lasting insecticidal nets or standard pyrethroid nets combined with indoor residual spraying?

    Malaria control today is threatened by widespread insecticide resistance in vector populations. The World Health Organization (WHO) recommends the use of a mixture of unrelated insecticides for indoor residual...

    Corine Ngufor, Josias Fagbohoun, Jessica Critchley, Raphael N’Guessan, Damien Todjinou, David Malone, Martin Akogbeto and Mark Rowland

    Malaria Journal 2017 16:340

    Published on: 16 August 2017

  7. Research

    The implementation of long-lasting insecticidal bed nets has differential effects on the genetic structure of the African malaria vectors in the Anopheles gambiae complex in Dielmo, Senegal

    Mosquitoes belonging to the Anopheles gambiae complex are the main vectors of malaria in sub-Saharan Africa. Among these, An. gambiae, Anopheles coluzzii and Anopheles arabiensis are the most efficient vectors an...

    Seynabou Sougoufara, Cheikh Sokhna, Nafissatou Diagne, Souleymane Doucouré, Pape MBacké Sembène and Myriam Harry

    Malaria Journal 2017 16:337

    Published on: 15 August 2017

  8. Review

    Circulating microRNAs in malaria infection: bench to bedside

    Severe malaria has a poor prognosis with a morbidity rate of 80% in tropical areas. The early parasite detection is one of the effective means to prevent severe malaria of which specific treatment strategies a...

    Supat Chamnanchanunt, Suthat Fucharoen and Tsukuru Umemura

    Malaria Journal 2017 16:334

    Published on: 15 August 2017

  9. Research

    Molecular analysis demonstrates high prevalence of chloroquine resistance but no evidence of artemisinin resistance in Plasmodium falciparum in the Chittagong Hill Tracts of Bangladesh

    Artemisinin resistance is present in the Greater Mekong region and poses a significant threat for current anti-malarial treatment guidelines in Bangladesh. The aim of this molecular study was to assess the cur...

    Mohammad Shafiul Alam, Benedikt Ley, Maisha Khair Nima, Fatema Tuj Johora, Mohammad Enayet Hossain, Kamala Thriemer, Sarah Auburn, Jutta Marfurt, Ric N. Price and Wasif A. Khan

    Malaria Journal 2017 16:335

    Published on: 15 August 2017

  10. Research

    ‘Repel all biters’: an enhanced collection of endophilic Anopheles gambiae and Anopheles arabiensis in CDC light-traps, from the Kagera Region of Tanzania, in the presence of a combination mosquito net impregnated with piperonyl butoxide and permethrin

    Mosquito nets containing synergists designed to overcome metabolic resistance mechanisms in vectors have been developed. These may enhance excitability in the mosquitoes and affect how they respond to CDC ligh...

    Corey LeClair, Judith Cronery, Enock Kessy, Elsa V. E. Tomás, Yohannes Kulwa, Franklin W. Mosha, Mark Rowland, Natacha Protopopoff and J. Derek Charlwood

    Malaria Journal 2017 16:336

    Published on: 15 August 2017

  11. Case report

    Cryptic Plasmodium ovale concurrent with mixed Plasmodium falciparum and Plasmodium malariae infection in two children from Central African Republic

    Since several malaria parasite species are usually present in a particular area, co-infections with more than one species of Plasmodium are more likely to occur in humans infected in these areas. In many mixed in...

    Cynthia Bichara, Philippe Flahaut, Damien Costa, Anne-Lise Bienvenu, Stephane Picot and Gilles Gargala

    Malaria Journal 2017 16:339

    Published on: 15 August 2017

  12. Research

    Clinical and molecular surveillance of artemisinin resistant falciparum malaria in Myanmar (2009–2013)

    Emergence of artemisinin-resistant malaria in Southeast Asian countries threatens the global control of malaria. Although K13 kelch propeller has been assessed for artemisinin resistance molecular marker, most...

    Myat Htut Nyunt, Myat Thu Soe, Hla Win Myint, Htet Wai Oo, Moe Moe Aye, Soe Soe Han, Ni Ni Zaw, Cho Cho, Phyo Zaw Aung, Khin Thiri Kyaw, Thin Thin Aye, Naychi Aung San, Leonard Ortega, Krongthong Thimasarn, Maria Dorina G. Bustos, Sherwin Galit…

    Malaria Journal 2017 16:333

    Published on: 14 August 2017

  13. Research

    Artemisinin combination therapy mass drug administration in a setting of low malaria endemicity: programmatic coverage and adherence during an observational study in Zanzibar

    Mass drug administration (MDA) appears to be effective in reducing the risk of malaria parasitaemia. This study reports on programmatic coverage and compliance of MDA using artemisinin-based combination therap...

    Abdullah S. Ali, Narjis G. Thawer, Bakar Khatib, Haji H. Amier, Joseph Shija, Mwinyi Msellem, Abdul-wahid Al-mafazy, Issa A. Garimo, Humphrey Mkali, Mahdi M. Ramsan, Jessica M. Kafuko, Lynn A. Paxton, Richard Reithinger and Jeremiah M. Ngondi

    Malaria Journal 2017 16:332

    Published on: 14 August 2017

  14. Research

    Life-span of in vitro differentiated Plasmodium falciparum gametocytes

    The sexual stages (gametocytes) of Plasmodium falciparum do not directly contribute to the pathology of malaria but are essential for transmission of the parasite from the human host to the mosquito. Mature gamet...

    Tamirat Gebru, Albert Lalremruata, Peter G. Kremsner, Benjamin Mordmüller and Jana Held

    Malaria Journal 2017 16:330

    Published on: 11 August 2017

  15. Research

    The Duffy binding protein (PkDBPαII) of Plasmodium knowlesi from Peninsular Malaysia and Malaysian Borneo show different binding activity level to human erythrocytes

    The zoonotic Plasmodium knowlesi is a major cause of human malaria in Malaysia. This parasite uses the Duffy binding protein (PkDBPαII) to interact with the Duffy antigen receptor for chemokines (DARC) receptor o...

    Khai Lone Lim, Amirah Amir, Yee Ling Lau and Mun Yik Fong

    Malaria Journal 2017 16:331

    Published on: 11 August 2017

  16. Research

    Evaluation of community-based continuous distribution of long-lasting insecticide-treated nets in Toamasina II District, Madagascar

    Continuous distribution of insecticide-treated nets (ITNs) is thought to be an effective mechanism to maintain ITN ownership and access between or in the absence of mass campaigns, but evidence is limited. A c...

    Celine Zegers de Beyl, Albert Kilian, Andrea Brown, Mohamad Sy-Ar, Richmond Ato Selby, Felicien Randriamanantenasoa, Jocelyn Ranaivosoa, Sixte Zigirumugabe, Lilia Gerberg, Megan Fotheringham, Matthew Lynch and Hannah Koenker

    Malaria Journal 2017 16:327

    Published on: 10 August 2017

  17. Research

    Barriers to routine G6PD testing prior to treatment with primaquine

    Primaquine is essential for the radical cure of vivax malaria, however its broad application is hindered by the risk of drug-induced haemolysis in individuals with glucose-6-phosphate-dehydrogenase (G6PD) defi...

    Benedikt Ley, Kamala Thriemer, Jessica Jaswal, Eugenie Poirot, Mohammad Shafiul Alam, Ching Swe Phru, Wasif Ali Khan, Lek Dysoley, Gao Qi, Chong Chee Kheong, Ummi Kalthom Shamsudin, Ingrid Chen, Jimee Hwang, Roly Gosling and Ric N. Price

    Malaria Journal 2017 16:329

    Published on: 10 August 2017

  18. Research

    Measuring the impact of seasonal malaria chemoprevention as part of routine malaria control in Kita, Mali

    Seasonal malaria chemoprevention (SMC) is a new strategy recommended by WHO in areas of highly seasonal transmission in March 2012. Although randomized controlled trials (RCTs) have shown SMC to be highly effe...

    Fatou Diawara, Laura C. Steinhardt, Almahamoudou Mahamar, Tiangoua Traore, Daouda T. Kone, Halimatou Diawara, Beh Kamate, Diakalia Kone, Mouctar Diallo, Aboubacar Sadou, Jules Mihigo, Issaka Sagara, Abdoulaye A. Djimde, Erin Eckert and Alassane Dicko

    Malaria Journal 2017 16:325

    Published on: 10 August 2017

  19. Case report

    First record of Anopheles stephensi in Sri Lanka: a potential challenge for prevention of malaria reintroduction

    The major malaria vector in Sri Lanka is reported to be Anopheles culicifacies with Anopheles subpictus, Anopheles annularis, and Anopheles varuna considered as potential vectors. The occurrence of Anopheles step...

    A. G. Gayan Dharmasiri, A. Yashan Perera, Jeevanie Harishchandra, Hemantha Herath, Kandasamy Aravindan, H. T. R. Jayasooriya, Gaya R. Ranawaka and Mihirini Hewavitharane

    Malaria Journal 2017 16:326

    Published on: 10 August 2017

  20. Research

    A reduction in malaria transmission intensity in Northern Ghana after 7 years of indoor residual spraying

    Indoor residual spraying (IRS) is being implemented as one of the malaria prevention methods in the Northern Region of Ghana. Changes in longevity, sporozoite and entomological inoculation rates (EIRs) of majo...

    Sylvester Coleman, Samuel K. Dadzie, Aklilu Seyoum, Yemane Yihdego, Peter Mumba, Dereje Dengela, Philip Ricks, Kristen George, Christen Fornadel, Daniel Szumlas, Paul Psychas, Jacob Williams, Maxwell A. Appawu and Daniel A. Boakye

    Malaria Journal 2017 16:324

    Published on: 10 August 2017

  21. Research

    Evaluation of CareStart™ Malaria HRP2/pLDH (Pf/pan) Combo Test in a malaria low transmission region of Senegal

    This study was initiated from the observation that prevalence of malaria obtained with rapid diagnostic test (RDT) (CareStart™Malaria HRP2/pLDH Combo Test) was higher than in microscopy in a malaria low transm...

    Mamadou Alpha Diallo, Khadim Diongue, Mouhamadou Ndiaye, Amy Gaye, Awa Deme, Aida S. Badiane and Daouda Ndiaye

    Malaria Journal 2017 16:328

    Published on: 10 August 2017

  22. Research

    Prevalence of polymorphisms in glucose-6-phosphate dehydrogenase, sickle haemoglobin and nitric oxide synthase genes and their relationship with incidence of uncomplicated malaria in Iganga, Uganda

    Host genetics play an important role in Plasmodium falciparum malaria susceptibility. However, information on host genetic factors and their relationships with malaria in the vaccine trial site of Iganga, Uganda ...

    Catherine Nassozi Lwanira, Fred Kironde, Mark Kaddumukasa and Göte Swedberg

    Malaria Journal 2017 16:322

    Published on: 9 August 2017

  23. Methodology

    Hydrophilic-treated plastic plates for wide-range analysis of Giemsa-stained red blood cells and automated Plasmodium infection rate counting

    Malaria is a red blood cell (RBC) infection caused by Plasmodium parasites. To determine RBC infection rate, which is essential for malaria study and diagnosis, microscopic evaluation of Giemsa-stained thin blood...

    Muneaki Hashimoto, Shouki Yatsushiro, Shohei Yamamura, Masato Tanaka, Hirokazu Sakamoto, Yusuke Ido, Kazuaki Kajimoto, Mika Bando, Jun-ichi Kido and Masatoshi Kataoka

    Malaria Journal 2017 16:321

    Published on: 8 August 2017

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