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  1. Content type: Research

    This study seeks to compare the performance of HRP2 (First Response) and pLDH/HRP2 (Combo) RDTs for falciparum malaria against microscopy and PCR in acutely ill febrile children at presentation and follow-up.

    Authors: Isabella A. Quakyi, George O. Adjei, David J. Sullivan Jr., Amos Laar, Judith K. Stephens, Richmond Owusu, Peter Winch, Kwame S. Sakyi, Nathaniel Coleman, Francis D. Krampa, Edward Essuman, Vivian N. A. Aubyn, Isaac A. Boateng, Bernard B. Borteih, Linda Vanotoo, Juliet Tuakli…

    Citation: Malaria Journal 2018 17:468

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  2. Content type: Case report

    Congenital malaria is usually defined as the detection of asexual forms of Plasmodium spp. in a blood sample of a neonate during perinatal age if there is no possibility of postpartum infection by a mosquito bite...

    Authors: Lorenza Romani, Stefania Pane, Carlo Severini, Michela Menegon, Gianluca Foglietta, Stefania Bernardi, Hyppolite K. Tchidjou, Andrea Onetti Muda, Paolo Palma and Lorenza Putignani

    Citation: Malaria Journal 2018 17:470

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  3. Content type: Opinion

    According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child. The administration of intermittent preven...

    Authors: Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines

    Citation: Malaria Journal 2018 17:469

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  4. Content type: Research

    For the success of the malaria control and eradication programme it is essential to reduce parasite transmission by mosquito vectors. In the midguts of mosquitoes fed with parasite-infected blood, sexual-stage...

    Authors: Rachaneeporn Jenwithisuk, Niwat Kangwanrangsan, Mayumi Tachibana, Amporn Thongkukiatkul, Hitoshi Otsuki, Jetsumon Sattabongkot, Takafumi Tsuboi, Motomi Torii and Tomoko Ishino

    Citation: Malaria Journal 2018 17:466

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  5. Content type: Research

    Evolutionary pressure by Plasmodium falciparum malaria is known to have favoured a large number of human gene adaptations, but there is surprisingly little investigation of the effect of malaria on human mitochon...

    Authors: Casey Fowler, Christine Cserti-Gazdewich, Aggrey Dhabangi, Charles Musoke, Himanshu Sharma, Sami S. Amr and Walter Dzik

    Citation: Malaria Journal 2018 17:467

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  6. Content type: Research

    The continued spectre of resistance to existing anti-malarials necessitates the pursuit of novel targets and mechanisms of action for drug development. One class of promising targets consists of the 80S riboso...

    Authors: Christine Moore Sheridan, Valentina E. Garcia, Vida Ahyong and Joseph L. DeRisi

    Citation: Malaria Journal 2018 17:465

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  7. Content type: Research

    Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inf...

    Authors: Filip C. Castberg, Edem W. Sarbah, Kwadwo A. Koram, Nicholas Opoku, Michael F. Ofori, Bjarne Styrishave, Lars Hviid and Jørgen A. L. Kurtzhals

    Citation: Malaria Journal 2018 17:464

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  8. Content type: Review

    Reaching the overall goal of eliminating malaria requires halting disease transmission. One approach to blocking transmission is to prevent passage of the parasite to a mosquito, by preventing formation or tra...

    Authors: Jeremy Burrows, Hannah Slater, Fiona Macintyre, Sarah Rees, Anna Thomas, Fredros Okumu, Rob Hooft van Huijsduijnen, Stephan Duparc and Timothy N. C. Wells

    Citation: Malaria Journal 2018 17:462

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  9. Content type: Research

    Spreading Plasmodium falciparum artemisinin drug resistance threatens global malaria public health gains. Limited data exist to define the extent of P. falciparum artemisinin resistance southeast of the Greater M...

    Authors: Matthew J. Grigg, Timothy William, Kim A. Piera, Giri S. Rajahram, Jenarun Jelip, Ammar Aziz, Jayaram Menon, Jutta Marfurt, Ric N. Price, Sarah Auburn, Bridget E. Barber, Tsin W. Yeo and Nicholas M. Anstey

    Citation: Malaria Journal 2018 17:463

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  10. Content type: Research

    In malaria endemic countries, asymptomatic cases constitute an important reservoir of infections sustaining transmission. Estimating the burden of the asymptomatic population and identifying areas with elevate...

    Authors: Mady Ouédraogo, Sékou Samadoulougou, Toussaint Rouamba, Hervé Hien, John E. M. Sawadogo, Halidou Tinto, Victor A. Alegana, Niko Speybroeck and Fati Kirakoya-Samadoulougou

    Citation: Malaria Journal 2018 17:460

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  11. Content type: Research

    In Tanzania, the roles of men and women are classified based on the local cultural context. While men are usually the breadwinners, women are traditionally responsible for most domestic chores. Particularly fo...

    Authors: Angel Dillip, Zawadi Mageni Mboma, George Greer and Lena M. Lorenz

    Citation: Malaria Journal 2018 17:459

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  12. Content type: Research

    Ensuring malaria commodity availability at health facilities is a cornerstone of malaria control. Since 2013, the Guinea National Malaria Control Programme has been routinely collecting data on stock levels of...

    Authors: Yu Sun, Timothée Guilavogui, Alioune Camara, Mohamed Dioubaté, Babacar Deen Toure, Claude Bahati, Marie Paule Fargier, Jessica Butts, Patrick Condo, Abdoulaye Sarr and Mateusz M. Plucinski

    Citation: Malaria Journal 2018 17:461

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  13. Content type: Research

    Malaria is still a serious public health problem on Bioko Island (Equatorial Guinea), although the number of annual cases has been greatly reduced since 2004 through the Bioko Island Malaria Control Project (B...

    Authors: Jiang-Tao Chen, Jian Li, Guang-Cai Zha, Guang Huang, Zhi-Xiu Huang, Dong-De Xie, Xia Zhou, Huan-Tong Mo, Juan Urbano Monsuy Eyi, Rocio Apicante Matesa, Maximo Miko Ondo Obono, Shan Li, Xiang-Zhi Liu and Min Lin

    Citation: Malaria Journal 2018 17:458

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  14. Content type: Research

    Malaria is still a major public health concern in Bangladesh in spite of mass distribution of long-lasting insecticide-treated nets (LLINs) as a key preventive strategy. There might be a considerable gap betwe...

    Authors: Fouzia Khanam, Md Belal Hossain, Tridib Roy Chowdhury, Md Sajedur Rahman, Moktadir Kabir, Shamsun Naher, Md Akramul Islam and Mahfuzar Rahman

    Citation: Malaria Journal 2018 17:455

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  15. Content type: Methodology

    The malaria Eradication Research Agenda (malERA) has identified human-to-mosquito transmission of Plasmodium falciparum as a major target for eradication. The cornerstone for identifying and evaluating transmissi...

    Authors: Ashutosh K. Pathak, Justine C. Shiau, Matthew B. Thomas and Courtney C. Murdock

    Citation: Malaria Journal 2018 17:457

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  16. Content type: Research

    Plasmodium falciparum haemozoin, a detoxification product of digested haemoglobin from infected erythrocytes, is released into the bloodstream upon schizont rupture and accumulates in leukocytes. High levels of h...

    Authors: Yolanda Corbett, Sarah D’Alessandro, Silvia Parapini, Diletta Scaccabarozzi, Parisa Kalantari, Stefania Zava, Flavio Giavarini, Donatella Caruso, Irma Colombo, Timothy J. Egan and Nicoletta Basilico

    Citation: Malaria Journal 2018 17:456

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  17. Content type: Review

    The core vector control measures, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), reduce the risk of malaria infection by targeting indoor biting mosquitoes. These two interventions ...

    Authors: Taye Gari and Bernt Lindtjørn

    Citation: Malaria Journal 2018 17:454

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  18. Content type: Research

    A nationwide, school, malaria survey was implemented to assess the risk factors of malaria prevalence and bed net use among primary school children in mainland Tanzania. This allowed the mapping of malaria pre...

    Authors: Frank Chacky, Manuela Runge, Susan F. Rumisha, Pendael Machafuko, Prosper Chaki, Julius J. Massaga, Ally Mohamed, Emilie Pothin, Fabrizio Molteni, Robert W. Snow, Christian Lengeler and Renata Mandike

    Citation: Malaria Journal 2018 17:452

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  19. Content type: Research

    In Ethiopia, medicinal plants have been used to treat different diseases, including malaria, for many centuries. People living in rural areas are especially noted for their use of medicinal plants as a major c...

    Authors: Abyot Endale Gurmu, Teresa Kisi, Habteweld Shibru, Bertrand Graz and Merlin Willcox

    Citation: Malaria Journal 2018 17:451

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  20. Content type: Research

    When malaria transmission is very low, investigation of passively detected malaria cases and reactive focal testing and treatment (FTAT) in the case and neighbouring households can identify and contain the sou...

    Authors: Pooja Bansil, Asnakew K. Yeshiwondim, Caterina Guinovart, Belendia Serda, Callie Scott, Berhane H. Tesfay, Adem Agmas, Belay Bezabih, Melkamu T. Zeleke, Girma S. Guesses, Asmamaw L. Ayenew, Worku M. Workie, Duncan Earle, Rick W. Steketee and Asefaw Getachew

    Citation: Malaria Journal 2018 17:449

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  21. Content type: Research

    Plasmodium falciparum infected erythrocytes sequestering in placental tissue release Plasmodium lactate dehydrogenase (pLDH) and histidine-rich protein-II (HRP-II). These proteins can be detected in peripheral bl...

    Authors: Rosette Megnekou, Jean Claude Djontu, Benderli C. Nana, Jude D. Bigoga, Maurice Fotso, Balotin Fogang and Rose F. G. Leke

    Citation: Malaria Journal 2018 17:450

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  22. Content type: Case report

    Plasmodium knowlesi, a malaria parasite typically found in long-tailed and pig-tailed macaques, is the most common cause of human malaria in Malaysian Borneo. Infections in humans result in a spectrum of disease,...

    Authors: Chee Yik Chang, Wei Chieng Pui, Khamisah Abdul Kadir and Balbir Singh

    Citation: Malaria Journal 2018 17:448

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  23. Content type: Research

    Despite its immunogenicity, the polymorphic nature of merozoite surface protein 1, an important vaccine candidate for Plasmodium falciparum malaria, remains a concern. This study analyses the impact of genetic va...

    Authors: Sharmistha Ghoshal, Pragya Gajendra, Sumana Datta Kanjilal, Mitashree Mitra and Sanghamitra Sengupta

    Citation: Malaria Journal 2018 17:447

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  24. Content type: Research

    The steady supply of quality, affordable medicines is a pillar of a functioning health system. In addition to the public sector, the private, mission and not-for-profit sectors often serve a large part of the ...

    Authors: Renia Coghlan, Peter Stephens, Bernice Mwale and Makomani Siyanga

    Citation: Malaria Journal 2018 17:444

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  25. Content type: Research

    The C-terminal 42 kDa domain of Plasmodium knowlesi merozoite surface protein 1 (PkMSP1) is a potential asexual blood-stage vaccine candidate, however, only a limited number of clinical isolates have been analyse...

    Authors: Md Atique Ahmed, Ki-Back Chu, Indra Vythilingam and Fu-Shi Quan

    Citation: Malaria Journal 2018 17:442

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  26. Content type: Research

    Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature ...

    Authors: Patricia Schlagenhauf, Martin P. Grobusch, Davidson H. Hamer, Hilmir Asgeirsson, Mogens Jensenius, Gilles Eperon, Camilla Rothe, Egon Isenring, Jan Fehr, Eli Schwartz, Emmanuel Bottieau, Elizabeth D. Barnett, Anne McCarthy, Paul Kelly, Carsten Schade Larsen, Perry van Genderen…

    Citation: Malaria Journal 2018 17:443

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  27. Content type: Research

    The transmission of malaria to mosquitoes depends on the presence of gametocytes that circulate in the peripheral blood of infected human hosts. Sensitive estimates of the densities of female gametocytes (FG) ...

    Authors: Lisette Meerstein-Kessel, Chiara Andolina, Elvira Carrio, Almahamoudou Mahamar, Patrick Sawa, Halimatou Diawara, Marga van de Vegte-Bolmer, Will Stone, Katharine A. Collins, Petra Schneider, Alassane Dicko, Chris Drakeley, Ingrid Felger, Till Voss, Kjerstin Lanke and Teun Bousema

    Citation: Malaria Journal 2018 17:441

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  28. Content type: Research

    Accurate diagnosis of malaria and reduced reliance on presumptive treatment are crucial components of quality case management. From 2008 to 2012, the Improving Malaria Diagnostics project, in collaboration wit...

    Authors: Matt Worges, Nicole Whitehurst, Emanuel Yamo, Hawela Moonga, Joshua Yukich and Luis Benavente

    Citation: Malaria Journal 2018 17:438

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  29. Content type: Research

    Malaria in Nigeria is principally due to Plasmodium falciparum and, to a lesser extent to Plasmodium malariae and Plasmodium ovale. Plasmodium vivax is thought to be absent in Nigeria in particular and sub-Sahara...

    Authors: Mary Aigbiremo Oboh, Aida Sadikh Badiane, Godwin Ntadom, Yaye Die Ndiaye, Khadim Diongue, Mamadou Alpha Diallo and Daouda Ndiaye

    Citation: Malaria Journal 2018 17:439

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  30. Content type: Research

    Ecuador is on the verge of eliminating malaria according to the World Health Organization criteria. Nevertheless, active transmission foci still persist in the country, and these represent an important challen...

    Authors: Mayte Mosquera-Romero, Lina Zuluaga-Idárraga and Alberto Tobón-Castaño

    Citation: Malaria Journal 2018 17:440

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  31. Content type: Research

    The emergence of mosquitoes that can avoid indoor-deployed interventions, such as treated bed nets and indoor residual spraying, threatens the mainstay of malaria control in Zambia. Furthermore, the requiremen...

    Authors: Jennifer C. Stevenson, Limonty Simubali, Twig Mudenda, Esther Cardol, Ulrich R. Bernier, Agustin Abad Vazquez, Philip E. Thuma, Douglas E. Norris, Melynda Perry, Daniel L. Kline, Lee W. Cohnstaedt, Pablo Gurman, Sebastian D’hers and Noel M. Elman

    Citation: Malaria Journal 2018 17:437

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  32. Content type: Research

    Cerebral malaria (CM) is often fatal, and severe brain swelling is a predictor of CM-related mortality. CM is characterized by elevated circulating pro-inflammatory cytokines TNF and IFN-γ and anti-inflammator...

    Authors: Visopo Harawa, Madi Njie, Anne Kessler, Augustine Choko, Benjamin Kumwenda, Sam Kampondeni, Michael Potchen, Kami Kim, Anthony Jaworowski, Terrie Taylor, Wilson Mandala, Karl Seydel and Stephen Rogerson

    Citation: Malaria Journal 2018 17:435

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  33. Content type: Research

    Chloroquine treatment for Plasmodium falciparum has been discontinued in almost all endemic regions due to the spread of resistant isolates. Reversal of chloroquine susceptibility after chloroquine discontinuatio...

    Authors: Makoto Sekihara, Shin-Ichiro Tachibana, Masato Yamauchi, Shoki Yatsushiro, Steven Tiwara, Naoyuki Fukuda, Mie Ikeda, Toshiyuki Mori, Makoto Hirai, Francis Hombhanje and Toshihiro Mita

    Citation: Malaria Journal 2018 17:434

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  34. Content type: Research

    Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum. Aspidosperma pyrifolium, also a medicinal plant, is used as a natural anti-inflamm...

    Authors: Isabela P. Ceravolo, Carlos L. Zani, Flávio J. B. Figueiredo, Markus Kohlhoff, Antônio E. G. Santana and Antoniana U. Krettli

    Citation: Malaria Journal 2018 17:436

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  35. Content type: Case study

    Uganda adopted the Integrated Management of Malaria (IMM) guidelines, which require testing all suspected cases of malaria prior to treatment and which have been implemented throughout the country. However, ad...

    Authors: Henry Kaula, Sylvia Kiconco and Luigi Nuñez

    Citation: Malaria Journal 2018 17:432

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  36. Content type: Commentary

    Prompted by the 20th anniversary of Roll Back Malaria, the author recalls hypotheses concerning a major new initiative to control malaria in Africa put forward by WHO AFRO and the World Bank in 1996. These hyp...

    Authors: Sir Richard Feachem

    Citation: Malaria Journal 2018 17:433

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  37. Content type: Correction

    Following publication of the original article [1], one of the authors flagged that the images for Figs. 2 and 3 were swapped in the published article—Fig. 2 had the image meant for Fig. 3 and vice versa.

    Authors: Isabelle Jeanne, Lynda E. Chambers, Adna Kazazic, Tanya L. Russell, Albino Bobogare, Hugo Bugoro, Francis Otto, George Fafale and Amanda Amjadali

    Citation: Malaria Journal 2018 17:431

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    The original article was published in Malaria Journal 2018 17:381

  38. Content type: Research

    Malaria cases among mobile and migrant populations (MMPs) represent a large and important reservoir for transmission, if undetected or untreated. The objectives of this review were to identify which intersecto...

    Authors: Cho Naing, Maxine A. Whittaker and Marcel Tanner

    Citation: Malaria Journal 2018 17:430

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  39. Content type: Research

    One challenge in moving towards malaria elimination is cross-border malaria infection. The implemented measures to prevent and control malaria re-introduction across the demarcation line between two countries ...

    Authors: Aung Minn Thway, Chawarat Rotejanaprasert, Jetsumon Sattabongkot, Siam Lawawirojwong, Aung Thi, Tin Maung Hlaing, Thiha Myint Soe and Jaranit Kaewkungwal

    Citation: Malaria Journal 2018 17:428

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  40. Content type: Case report

    The country received malaria-free certification from WHO in September 2016, becoming only the second country in the WHO South East Asia region to be declared malaria-free. Imported malaria cases continue to be...

    Authors: Dewanee Ranaweera, R. M. J. Kanchana Rajapaksha, Priyanganie Silva, Raja Hettiarachchi, W. M. Kumudu T. de A. W. Gunasekera, Hemantha Herath and Deepika Fernando

    Citation: Malaria Journal 2018 17:429

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  41. Content type: Research

    A multi-country, community-based trial on scheduled screening and treatment for malaria in pregnancy was conducted in Benin, The Gambia and Burkina Faso. Despite standardized procedures and outcomes, the study...

    Authors: Adélaïde Compaoré, Susan Dierickx, Fatou Jaiteh, Alain Nahum, Towanou Francis Emmanuel Bohissou, Halidou Tinto, Susana Scott, Umberto D’Alessandro, Henk Schallig and Koen Peeters Grietens

    Citation: Malaria Journal 2018 17:425

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  42. Content type: Research

    The intimate interaction between the pathophysiology of the human host and the biology of the Plasmodium falciparum parasite results in a wide spectrum of disease outcomes in malaria. Development of severe diseas...

    Authors: Philippa Reuterswärd, Sofia Bergström, Judy Orikiiriza, Elisabeth Lindquist, Sven Bergström, Helene Andersson Svahn, Burcu Ayoglu, Mathias Uhlén, Mats Wahlgren, Johan Normark, Ulf Ribacke and Peter Nilsson

    Citation: Malaria Journal 2018 17:426

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  43. Content type: Methodology

    Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine. Primaquine, a prod...

    Authors: Kanokpich Puaprasert, Cindy Chu, Naowarat Saralamba, Nicholas P. J. Day, Francois Nosten, Nicholas J. White, Arjen M. Dondorp and Mallika Imwong

    Citation: Malaria Journal 2018 17:427

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  44. Content type: Research

    Major investments have been made since 2001, with intensification of malaria control interventions after 2006. Interventions included free distribution of insecticide-treated nets (ITN) to pregnant women and chil...

    Authors: Kassoum Kayentao, Lia S. Florey, Jules Mihigo, Abdoul Doumbia, Aliou Diallo, Diakalia Koné, Ogobara Doumbo and Erin Eckert

    Citation: Malaria Journal 2018 17:424

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  45. Content type: Research

    The degree to which insecticide-treated net (ITN) supply accounts for age and gender disparities in ITN use among household members is unknown. This study explores the role of household ITN supply in the varia...

    Authors: Bolanle Olapeju, Ifta Choiriyyah, Matthew Lynch, Angela Acosta, Sean Blaufuss, Eric Filemyr, Hunter Harig, April Monroe, Richmond Ato Selby, Albert Kilian and Hannah Koenker

    Citation: Malaria Journal 2018 17:423

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  46. Content type: Case study

    The use of insecticides is the cornerstone of effective malaria vector control. However, the last two decades has seen the ubiquitous use of insecticides, predominantly pyrethroids, causing widespread insectic...

    Authors: Edward K. Thomsen, Charlotte Hemingway, Andy South, Kirsten A. Duda, Claire Dormann, Robert Farmer, Michael Coleman and Marlize Coleman

    Citation: Malaria Journal 2018 17:422

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  47. Content type: Research

    Long-lasting insecticidal nets (LLINs) are a key malaria control intervention. To investigate factors associated with ownership and use of LLINs in Uganda, a cross-sectional community survey was conducted in M...

    Authors: Samuel Gonahasa, Catherine Maiteki-Sebuguzi, Sheila Rugnao, Grant Dorsey, Jimmy Opigo, Adoke Yeka, Agaba Katureebe, Mary Kyohere, Amy Lynd, Janet Hemingway, Martin Donnelly, Moses R. Kamya and Sarah G. Staedke

    Citation: Malaria Journal 2018 17:421

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