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  1. Content type: Methodology

    Plasmodium falciparum drug resistance surveillance is key to successful disease control and eradication. Contemporary methods that only allow determination of prevalence of resistance are expensive, time consumin...

    Authors: Rebecca Smith-Aguasca, Himanshu Gupta, Estefania Uberegui, Mara Maquina, Francisco Saute, Krijn P. Paaijmans, Alfredo Mayor and Silvie Huijben

    Citation: Malaria Journal 2019 18:351

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  2. Content type: Research

    Malaria elimination requires diagnostic methods able to detect parasite levels well below what is currently possible with microscopy and rapid diagnostic tests. This is particularly true in surveillance of mal...

    Authors: Abu Naser Mohon, Sisay Getie, Nusrat Jahan, Mohammad Shafiul Alam and Dylan R. Pillai

    Citation: Malaria Journal 2019 18:350

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  3. Content type: Research

    The resistance of Plasmodium falciparum to artemisinin has been identified in Asia and some parts of Africa. The drug resistance of P. falciparum will be an obstacle to the successful elimination of malaria by 20...

    Authors: Jun Li, Yunliang Shi, Weiwei Zhang, Hui Yan, Kangming Lin, Shujiao Wei, Haiyan Wei, Yichao Yang, Shanping Huang, Yuxin Lu, Anxiang Ma and Jian Qin

    Citation: Malaria Journal 2019 18:349

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  4. Content type: Research

    Widespread elimination of malaria requires an ultra-sensitive detection method that can detect low parasitaemia levels seen in asymptomatic carriers who act as reservoirs for further transmission of the diseas...

    Authors: Philip Heraud, Patutong Chatchawal, Molin Wongwattanakul, Patcharaporn Tippayawat, Christian Doerig, Patcharee Jearanaikoon, David Perez-Guaita and Bayden R. Wood

    Citation: Malaria Journal 2019 18:348

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  5. Content type: Research

    Gene drive mosquitoes have been proposed as a possible means to reduce the transmission of malaria in Africa. Because this technology has no prior use-history at this time, environmental risk assessments for g...

    Authors: John L. Teem, Aggrey Ambali, Barbara Glover, Jeremy Ouedraogo, Diran Makinde and Andrew Roberts

    Citation: Malaria Journal 2019 18:347

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  6. Content type: Research

    Malaria is one of the deadliest infectious diseases caused by protozoan parasite of Plasmodium spp. Increasing resistance to anti-malarials has become global threat in control of the disease and demands for novel...

    Authors: Sonal Gupta, Juveria Khan, Priti Kumari, Chintam Narayana, R. Ayana, Malabika Chakrabarti, Ram Sagar and Shailja Singh

    Citation: Malaria Journal 2019 18:346

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  7. Content type: Research

    Malaria is a public health problem in the Brazilian Amazon region. In integrated vector management for malaria (anopheline) control, indoor residual spraying (IRS) represents one of the main tools in the basic...

    Authors: Ana Paula S. A. Corrêa, Allan K. R. Galardo, Luana A. Lima, Daniel C. P. Câmara, Josiane N. Müller, Jéssica Fernanda S. Barroso, Oscar M. M. Lapouble, Cynara M. Rodovalho, Kaio Augusto N. Ribeiro and José Bento P. Lima

    Citation: Malaria Journal 2019 18:345

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  8. Content type: Review

    Historically neglected, due to its biological peculiarities, the absence of a continuous long-term in vitro blood stage culture system and a propensity towards high morbidity rather than mortality, Plasmodium viv...

    Authors: Richard Thomson-Luque, John H. Adams, Clemens H. M. Kocken and Erica M. Pasini

    Citation: Malaria Journal 2019 18:344

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  9. Content type: Research

    A reversal of chloroquine (CQ) resistance following a period of withdrawal has raised the possibility of its re-introduction. This study evaluated the current prevalence of Pfcrt and Pfmdr1 alleles in Plasmodium ...

    Authors: Moses N. Ikegbunam, Charles N. Nkonganyi, Bolaji N. Thomas, Charles O. Esimone, Thirumalaisamy P. Velavan and Olusola Ojurongbe

    Citation: Malaria Journal 2019 18:343

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  10. Content type: Research

    Chloroquine (CQ) was the drug of choice for decades in the treatment of falciparum malaria until resistance emerged. CQ is suggested to accumulate in the parasite’s digestive vacuole (DV), where it unfolds its...

    Authors: Sarah J. Reiling and Petra Rohrbach

    Citation: Malaria Journal 2019 18:342

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  11. Content type: Research

    Epidemiological surveys of malaria currently rely on microscopy, polymerase chain reaction assays (PCR) or rapid diagnostic test kits for Plasmodium infections (RDTs). This study investigated whether mid-infrared...

    Authors: Emmanuel P. Mwanga, Elihaika G. Minja, Emmanuel Mrimi, Mario González Jiménez, Johnson K. Swai, Said Abbasi, Halfan S. Ngowo, Doreen J. Siria, Salum Mapua, Caleb Stica, Marta F. Maia, Ally Olotu, Maggy T. Sikulu-Lord, Francesco Baldini, Heather M. Ferguson, Klaas Wynne…

    Citation: Malaria Journal 2019 18:341

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  12. Content type: Research

    G6PD enzyme deficiency is a common enzymatic X-linked disorder. Deficiency of the G6PD enzyme can cause free radical-mediated oxidative damage to red blood cells, leading to premature haemolysis. Treatment of Pla...

    Authors: Eugenia Lo, Daibin Zhong, Beka Raya, Kareen Pestana, Cristian Koepfli, Ming-Chieh Lee, Delenasaw Yewhalaw and Guiyun Yan

    Citation: Malaria Journal 2019 18:340

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  13. Content type: Research

    The recent emergence in Southeast Asia of artemisinin resistance poses major threats to malaria control and elimination globally. Green nanotechnologies can constitute interesting tools for discovering anti-ma...

    Authors: Loick P. Kojom Foko, Francois Eya’ane Meva, Carole E. Eboumbou Moukoko, Agnes A. Ntoumba, Marie I. Ngaha Njila, Philippe Belle Ebanda Kedi, Lawrence Ayong and Leopold G. Lehman

    Citation: Malaria Journal 2019 18:337

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  14. Content type: Research

    Rapid diagnostic tests (RDTs) have been described as a source of genetic material to analyse malaria parasites in proof-of-concept studies. The increasing use of RDTs (e.g., in focal or mass screening and trea...

    Authors: The Trong Nguyen, Brice Nzigou Mombo, Albert Lalremruata, Erik Koehne, Rella Zoleko Manego, Lia Betty Dimessa Mbadinga, Ayola Akim Adegnika, Selidji Todagbe Agnandji, Bertrand Lell, Peter Gottfried Kremsner, Thirumalaisamy P Velavan, Michael Ramharter, Benjamin Mordmüller and Ghyslain Mombo-Ngoma

    Citation: Malaria Journal 2019 18:336

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  15. Content type: Research

    The decline in malaria cases and vectors is major milestone in fighting against malaria. The efficacy of MAGNet long-lasting insecticidal nets (MAGNet LLIN), an alpha-cypermethrin incorporated long-lasting net...

    Authors: Eliningaya J. Kweka, Patrick K. Tungu, Aneth M. Mahande, Humphrey D. Mazigo, Subira Sayumwe, Shandala Msangi, Lucile Lyaruu, John Waweru, William Kisinza and James Wangai

    Citation: Malaria Journal 2019 18:335

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  16. Content type: Research

    Mosquito saliva elicits immune responses in humans following mosquito blood feeding. Detection of human antibodies recognizing the Anopheles gambiae salivary gland protein 6 (gSG6) or the gSG6-P1 peptide in resid...

    Authors: Edgar J. M. Pollard, Catriona Patterson, Tanya L. Russell, Alan Apairamo, Jance Oscar, Bruno Arcà, Chris Drakeley and Thomas R. Burkot

    Citation: Malaria Journal 2019 18:334

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  17. Content type: Research

    Malaria caused by Plasmodium falciparum parasite is still known to be one of the most significant public health problems in sub-Saharan Africa. Genetic diversity of the Sudanese P. falciparum based on the diversi...

    Authors: Nouh S. Mohamed, Musab M. Ali Albsheer, Hanadi Abdelbagi, Emanuel E. Siddig, Mona A. Mohamed, Abdallah E. Ahmed, Rihab Ali Omer, Mohamed S. Muneer, Ayman Ahmed, Hussam A. Osman, Mohamed S. Ali, Ibrahim M. Eisa and Mohamed M. Elbasheir

    Citation: Malaria Journal 2019 18:333

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  18. Content type: Research

    Misuse of long-lasting insecticidal nets together with resistance of vectors to most of the insecticides for indoor residual spraying and impregnated nets threaten malaria vector control interventions, requiri...

    Authors: Aklilu Belay, Beyene Petros, Teshome Gebre-Michael and Meshesha Balkew

    Citation: Malaria Journal 2019 18:332

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  19. Content type: Research

    Febrile children seen in malaria hypo-endemic settings, such as the Greater Accra region (GAR) of Ghana are more likely to be suffering from a non-malarial febrile illness compared to those seen in hyper-endem...

    Authors: Harriet Affran Bonful, Adolf Kofi Awua, Martin Adjuik, Doris Tsekpetse, Richard Mawuko Kofi Adanu, Pricillia Awo Nortey, Augustine Ankomah and Kwadwo Ansah Koram

    Citation: Malaria Journal 2019 18:331

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  20. Content type: Research

    The complex life cycle of malaria parasites requires well-orchestrated stage specific gene expression. In the vertebrate host the parasites grow and multiply by schizogony in two different environments: within...

    Authors: Reto Caldelari, Sunil Dogga, Marc W. Schmid, Blandine Franke-Fayard, Chris J. Janse, Dominique Soldati-Favre and Volker Heussler

    Citation: Malaria Journal 2019 18:330

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  21. Content type: Research

    Distribution campaigns for insecticide-treated nets (ITN) have increased the use of ITNs in Malawi, but malaria prevalence remains high even among those using the nets. Previous studies have addressed ITN owne...

    Authors: Liana R. Andronescu, Andrea G. Buchwald, Jenna E. Coalson, Lauren Cohee, Andy Bauleni, Jenny A. Walldorf, Chifundo Kandangwe, Themba Mzilahowa, Terrie E. Taylor, Don P. Mathanga and Miriam K. Laufer

    Citation: Malaria Journal 2019 18:329

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  22. Content type: Research

    Duffy blood group antigens serve as receptors for Plasmodium vivax invasion into erythrocytes, and they are determined by polymorphisms of the Duffy antigen receptor for chemokines (DARC), also known as Fy glycop...

    Authors: Prabhanjan P. Gai, Welmoed van Loon, Konrad Siegert, Jakob Wedam, Suyamindra S. Kulkarni, Rashmi Rasalkar, Archith Boloor, Arun Kumar, Animesh Jain, Chakrapani Mahabala, Shantaram Baliga, Rajeshwari Devi, Damodara Shenoy, Pramod Gai and Frank P. Mockenhaupt

    Citation: Malaria Journal 2019 18:328

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  23. Content type: Research

    Different antigens are needed to characterize Plasmodium falciparum infection in terms of seroreactivity and targets for invasion inhibition, in order to guide and identify the proper use of such proteins as tool...

    Authors: Jorge Bendezu, Elizabeth Villasis, Sandra Morales Ruiz, Katherine Garro, Berónica Infante, Renzo Gutierrez-Loli, Pamela Rodríguez, Manolo Fernández-Díaz, Dionicia Gamboa and Katherine Torres

    Citation: Malaria Journal 2019 18:327

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  24. Content type: Research

    Poor knowledge on the afebrile Plasmodium falciparum biology limits elimination approaches to target asymptomatic malaria. Therefore, the association of parasite factors involved in cytoadhesion, parasite multipl...

    Authors: Himanshu Gupta, Beatriz Galatas, Gloria Matambisso, Lidia Nhamussua, Pau Cisteró, Quique Bassat, Aina Casellas, Eusébio Macete, John J. Aponte, Charfudin Sacoor, Pedro Alonso, Francisco Saúte, Caterina Guinovart, Pedro Aide and Alfredo Mayor

    Citation: Malaria Journal 2019 18:326

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  25. Content type: Research

    Activation of hypnozoites of vivax malaria causes multiple clinical relapses, which contribute to the Plasmodium vivax burden and continuing transmission. Artemisinin-based combination therapy (ACT) is effective ...

    Authors: André Daher, Ghait Aljayyoussi, Dhelio Pereira, Marcus V. G. Lacerda, Márcia A. A. Alexandre, Cristiana T. Nascimento, Júlio Castro Alves, Laís Bastos da Fonseca, Diego Medeiros Dias da Silva, Douglas Pereira Pinto, Danielle Fonseca Rodrigues, Ana Carolina Rios Silvino, Taís Nóbrega de Sousa, Cristiana Ferreira Alves de Brito, Feiko O. ter Kuile and David G. Lalloo

    Citation: Malaria Journal 2019 18:325

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  26. Content type: Meeting report

    Targeted Next Generation Sequencing (TNGS) is an efficient and economical Next Generation Sequencing (NGS) platform and the preferred choice when specific genomic regions are of interest. So far, only institut...

    Authors: Anita Ghansah, Edwin Kamau, Alfred Amambua-Ngwa, Deus S. Ishengoma, Oumou Maiga-Ascofare, Lucas Amenga-Etego, Awa Deme, William Yavo, Milijaona Randrianarivelojosia, Lynette Isabella Ochola-Oyier, Gideon Kofi Helegbe, Jeffery Bailey, Michael Alifrangis and Abdoulaye Djimde

    Citation: Malaria Journal 2019 18:324

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  27. Content type: Opinion

    This paper outlines Zimbabwe’s potential readiness in harnessing integrated vector management (IVM) strategy for enhanced control of vector-borne diseases. The objective is to provide guidance for the country ...

    Authors: Shadreck Sande, Moses Zimba, David Nyasvisvo, Munyaradzi Mukuzunga, Emmanuel H. Kooma, Joseph Mberikunashe and Busisani Dube

    Citation: Malaria Journal 2019 18:322

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  28. Content type: Research

    Over the past decade, food insecurity, connected to erratic rains and reduced agricultural outputs, has plagued Malawi. Many households are turning to fishing to seek additional sources of income and food. The...

    Authors: Sara Berthe, Steven A. Harvey, Matthew Lynch, Hannah Koenker, Vincent Jumbe, Blessings Kaunda-Khangamwa and Don P. Mathanga

    Citation: Malaria Journal 2019 18:320

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  29. Content type: Research

    Plasmodium falciparum, the deadliest causative agent of malaria, has high prevalence in Nigeria. Drug resistance causing failure of previously effective drugs has compromised anti-malarial treatment. On this basi...

    Authors: Abel O. Idowu, Wellington A. Oyibo, Sanjib Bhattacharyya, Manjeet Khubbar, Udoma E. Mendie, Violet V. Bumah, Carolyn Black, Joseph Igietseme and Anthony A. Azenabor

    Citation: Malaria Journal 2019 18:319

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  30. Content type: Research

    Intermittent preventive treatment (IPT) of malaria is recommended as policy for certain high-risk populations, but not currently for schoolchildren. A cluster-randomized trial was conducted to evaluate the eff...

    Authors: Andrea M. Rehman, Catherine Maiteki-Sebuguzi, Samuel Gonahasa, Jaffer Okiring, Simon P. Kigozi, Clare I. R. Chandler, Chris Drakeley, Grant Dorsey, Moses R. Kamya and Sarah G. Staedke

    Citation: Malaria Journal 2019 18:318

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  31. Content type: Research

    Plasmodium falciparum apical membrane antigen-1 (PfAMA-1) is a promising candidate antigen for a blood-stage malaria vaccine. However, antigenic variation and diversity of PfAMA-1 are still major problems to desi...

    Authors: Ya-Nan Wang, Min Lin, Xue-Yan Liang, Jiang-Tao Chen, Dong-De Xie, Yu-Ling Wang, Carlos Salas Ehapo, Urbano Monsuy Eyi, Hui-Ying Huang, Jing-Li Wu, Dan-Yan Xu, Zhi-Mao Chen, Yi-Long Cao and Hai-Bin Chen

    Citation: Malaria Journal 2019 18:317

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  32. Content type: Case report

    Plasmodium vivax infection is rising in sub-Saharan Africa, where Plasmodium falciparum is responsible for more than 90% of malaria cases. While P. vivax is identified as a major cause of severe and cerebral mala...

    Authors: Maowia M. Mukhtar, Omer A. Eisawi, Seth A. Amanfo, Elwaleed M. Elamin, Zeinab S. Imam, Faiza M. Osman and Manasik E. Hamed

    Citation: Malaria Journal 2019 18:316

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  33. Content type: Research

    Surveillance is a core component of an effective system to support malaria elimination. Poor surveillance data will prevent countries from monitoring progress towards elimination and targeting interventions to...

    Authors: Christopher Lourenço, Andrew J. Tatem, Peter M. Atkinson, Justin M. Cohen, Deepa Pindolia, Darlene Bhavnani and Arnaud Le Menach

    Citation: Malaria Journal 2019 18:315

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  34. Content type: Research

    Eave ribbons treated with spatial repellents effectively prevent human exposure to outdoor-biting and indoor-biting malaria mosquitoes, and could constitute a scalable and low-cost supplement to current interv...

    Authors: Emmanuel P. Mwanga, Arnold S. Mmbando, Paul C. Mrosso, Caleb Stica, Salum A. Mapua, Marceline F. Finda, Khamis Kifungo, Andrew Kafwenji, April C. Monroe, Sheila B. Ogoma, Halfan S. Ngowo and Fredros O. Okumu

    Citation: Malaria Journal 2019 18:314

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  35. Content type: Research

    Malaria continues to impose a tremendous burden in terms of global morbidity and mortality, yet even today, a large number of diagnoses are presumptive resulting in lack of or inappropriate treatment.

    Authors: Jinsu Kim, Xiangkun Elvis Cao, Julia L. Finkelstein, Washington B. Cárdenas, David Erickson and Saurabh Mehta

    Citation: Malaria Journal 2019 18:313

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  36. Content type: Research

    Anaemia is a major consequence of malaria, caused by the removal of both infected and uninfected red blood cells (RBCs) from the circulation. Complement activation and reduced expression of complement regulato...

    Authors: Damian A. Oyong, Jessica R. Loughland, Arya SheelaNair, Dean Andrew, Fabian D. L. Rivera, Kim A. Piera, Timothy William, Matthew J. Grigg, Bridget E. Barber, Ashraful Haque, Christian R. Engwerda, James S. McCarthy, Nicholas M. Anstey and Michelle J. Boyle

    Citation: Malaria Journal 2019 18:312

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  37. Content type: Research

    Malaria remains one of the most important causes of morbidity and death in sub-Saharan Africa. Along with early diagnosis and treatment of malaria cases and intermittent preventive treatment in pregnancy (IPTp...

    Authors: Peter Dambach, Till Baernighausen, Issouf Traoré, Saidou Ouedraogo, Ali Sié, Rainer Sauerborn, Norbert Becker and Valérie R. Louis

    Citation: Malaria Journal 2019 18:311

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  38. Content type: Research

    After years of efforts on the control of malaria, it remains as a most deadly infectious disease. A major problem for the available anti-malarial drugs is the occurrence of drug resistance in Plasmodium. Developi...

    Authors: Saeed Yousefinejad, Marjan Mahboubifar and Rayhaneh Eskandari

    Citation: Malaria Journal 2019 18:310

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  39. Content type: Research

    Intensive malaria transmission along international borders is a significant impediment to malaria elimination in the Greater Mekong Subregion (GMS) of Southeast Asia. Passive case detection (PCD) was used to s...

    Authors: Jinting Geng, Pallavi Malla, Jiaqi Zhang, Shiling Xu, Cuiying Li, Yan Zhao, Qinghui Wang, Myat Phone Kyaw, Yaming Cao, Zhaoqing Yang and Liwang Cui

    Citation: Malaria Journal 2019 18:309

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  40. Content type: Research

    Malaria is one of the important vector-borne diseases with high fatality rates in tropical countries. The pattern of emergence and spread of novel antigenic variants, leading to escape of vaccine-induced immun...

    Authors: Hargobinder Kaur, Rakesh Sehgal, Archit Kumar, Alka Sehgal, Praveen K. Bharti, Devendra Bansal, Pradyumna K. Mohapatra, Jagadish Mahanta and Ali A. Sultan

    Citation: Malaria Journal 2019 18:308

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  41. Content type: Research

    While bed nets and insecticide spraying have had significant impact on malaria burden in many endemic regions, outdoor vector feeding and insecticide resistance may ultimately limit their contribution to elimi...

    Authors: Prashanth Selvaraj, Joshua Suresh, Edward A. Wenger, Caitlin A. Bever and Jaline Gerardin

    Citation: Malaria Journal 2019 18:307

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  42. Content type: Research

    Plasmodium falciparum malaria is a threat to public health, but Plasmodium vivax malaria is most prevalent in Latin America, where the incidence rate has been increasing since 2016, particularly in Venezuela and ...

    Authors: Meyrecler Aglair de Oliveira Padilha, Janille de Oliveira Melo, Guilherme Romano, Marcos Vinicius Malveira de Lima, Wladimir J. Alonso, Maria Anice Mureb Sallum and Gabriel Zorello Laporta

    Citation: Malaria Journal 2019 18:306

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  43. Content type: Review

    Next-generation sequencing (NGS) technologies are increasingly being used to address a diverse range of biological and epidemiological questions. The current understanding of malaria transmission dynamics and ...

    Authors: Sofonias K. Tessema, Jaishree Raman, Craig W. Duffy, Deus S. Ishengoma, Alfred Amambua-Ngwa and Bryan Greenhouse

    Citation: Malaria Journal 2019 18:268

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