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  1. Malaria is one of the leading causes of morbidity and mortality in African countries. It is one of the leading causes of hospital visits and hospitalization in pediatric wards for children under 5 years old. I...

    Authors: Gaëtan Moukoumbi Lipenguet, Edgard Brice Ngoungou, Euloge Ibinga, Jean Engohang-Ndong and Jérôme Wittwer

    Citation: Malaria Journal 2021 20:334

    Content type: Research

    Published on:

  2. Insecticide-treated nets (ITNs) are the most widely used interventions for malaria control in Africa. The aim of this study was to assess the ownership and utilization of ITNs and the knowledge of malaria and ...

    Authors: Rene Ning Teh, Irene Ule Ngole Sumbele, Derick Ndelle Meduke, Gillian Asoba Nkeudem, Samuel Takang Ojong, Exodus Akwa Teh and Helen Kuokuo Kimbi

    Citation: Malaria Journal 2021 20:333

    Content type: Research

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  3. Early malaria diagnosis and its profiling require the development of new sensing platforms enabling rapid and early analysis of parasites in blood or saliva, aside the widespread rapid diagnostic tests (RDTs).

    Authors: Médéric Loyez, Mathilde Wells, Stéphanie Hambÿe, François Hubinon, Bertrand Blankert, Ruddy Wattiez and Christophe Caucheteur

    Citation: Malaria Journal 2021 20:332

    Content type: Research

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  4. Authors: Meshesha Balkew, Peter Mumba, Gedeon Yohannes, Ephrem Abiy, Dejene Getachew, Solomon Yared, Amha Worku, Araya Gebresilassie, Fitsum G. Tadesse, Endalamaw Gadisa, Endashaw Esayas, Temesgen Ashine, Desta Ejeta, Sisay Dugassa, Mekonnen Yohannes, Wossenseged Lemma…

    Citation: Malaria Journal 2021 20:331

    Content type: Correction

    Published on:

    The original article was published in Malaria Journal 2021 20:263

  5. Information on cardiopulmonary complications in clinical malaria is sparse and diagnosis may be difficult in resource-limited areas due to lack of proper diagnostic tools and access to medical care. A case of ...

    Authors: Alma Wegener, Karine O. Lima, Anna E. Holm, Laura C. Gomes, Luan O. Matos, Isabelle V. M. Vieira, Rodrigo Medeiros Souza, Claudio Romero Farias Marinho, Lasse S. Vestergaard, Tor Biering-Sørensen, Odilson M. Silvestre and Philip Brainin

    Citation: Malaria Journal 2021 20:330

    Content type: Case report

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  6. In 2002, Zambia withdrew chloroquine as first-line treatment for Plasmodium falciparum malaria due to increased treatment failure and worldwide spread of chloroquine resistance. The artemisinin combination regime...

    Authors: Mwenda C. Mulenga, Lungowe Sitali, Ilinca I. Ciubotariu, Moonga B. Hawela, Busiku Hamainza, James Chipeta and Sungano Mharakurwa

    Citation: Malaria Journal 2021 20:329

    Content type: Research

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  7. The selection and the spread of insecticide resistance in malaria vectors to the main classes of insecticides used in vector control tools are a major and ongoing challenge to malaria vector control programmes...

    Authors: Casimir Dossou Kpanou, Hermann W. Sagbohan, Fortuné Dagnon, Germain G. Padonou, Razaki Ossè, Albert Sourou Salako, Aboubakar Sidick, Wilfried Sewadé, André Sominahouin, Patrick Condo, Saadani Hassani Ahmed, Daniel Impoinvil and Martin Akogbéto

    Citation: Malaria Journal 2021 20:328

    Content type: Research

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  8. Seasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period. Whether the addit...

    Authors: Koudraogo Bienvenue Yaméogo, Rakiswendé Serge Yerbanga, Seydou Bienvenu Ouattara, Franck A. Yao, Thierry Lefèvre, Issaka Zongo, Frederic Nikièma, Yves Daniel Compaoré, Halidou Tinto, Daniel Chandramohan, Brian Greenwood, Adrien M. G. Belem, Anna Cohuet and Jean Bosco Ouédraogo

    Citation: Malaria Journal 2021 20:326

    Content type: Research

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  9. Larviciding against malaria vectors in Africa has been limited to indoor residual spraying and insecticide-treated nets, but is increasingly being considered by some countries as a complementary strategy. Howe...

    Authors: Manuela Runge, Salum Mapua, Ismail Nambunga, Thomas A. Smith, Nakul Chitnis, Fredros Okumu and Emilie Pothin

    Citation: Malaria Journal 2021 20:324

    Content type: Research

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  10. Authors: Sreenivasulu B. Reddy, Noemi Nagy, Caroline Rönnberg, Francesca Chiodi, Allan Lugaajju, Frank Heuts, Laszlo Szekely, Mats Wahlgren and Kristina E. M. Persson

    Citation: Malaria Journal 2021 20:323

    Content type: Publisher Correction

    Published on:

    The original article was published in Malaria Journal 2021 20:303

  11. Extensive malaria control measures have been implemented on Bioko Island, Equatorial Guinea over the past 16 years, reducing parasite prevalence and malaria-related morbidity and mortality, but without achievi...

    Authors: Vicente Urbano Nsue Ndong Nchama, Ali Hamad Said, Ali Mtoro, Gertrudis Owono Bidjimi, Marta Alene Owono, Escolastica Raquel Mansogo Maye, Martin Eka Ondo Mangue, Genaro Nsue Nguema Okomo, Beltran Ekua Ntutumu Pasialo, Dolores Mbang Ondo, Maria-Silvia Angue Lopez, Fortunata Lobede Mochomuemue, Mariano Obiang Obono, Juan Carlos Momo Besaha, Raul Chuquiyauri, Said Abdallah Jongo…

    Citation: Malaria Journal 2021 20:322

    Content type: Research

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  12. Several studies that aim to enhance the understanding of malaria transmission and persistence in urban settings failed to address its underlining complexity. This study aims at doing that by applying qualitati...

    Authors: Merveille Koissi Savi, Daniel Callo-Concha, Henri E. Z. Tonnang and Christian Borgemeister

    Citation: Malaria Journal 2021 20:321

    Content type: Research

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  13. Following agricultural use and large-scale distribution of insecticide-treated nets (ITNs), malaria vector resistance to pyrethroids is widespread in sub-Saharan Africa. Interceptor® G2 is a new dual active in...

    Authors: Richard M. Oxborough, Aklilu Seyoum, Yemane Yihdego, Joseph Chabi, Francis Wat’senga, Fiacre R. Agossa, Sylvester Coleman, Samdi Lazarus Musa, Ousmane Faye, Michael Okia, Mohamed Bayoh, Evelyne Alyko, Jean-Desire Rakotoson, Hieronymo Masendu, Arthur Sovi, Libasse Gadiaga…

    Citation: Malaria Journal 2021 20:316

    Content type: Research

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  14. Saudi Arabia and Yemen are the only two countries in the Arabian Peninsula that are yet to achieve malaria elimination. Over the past two decades, the malaria control programme in Saudi Arabia has successfully...

    Authors: Hesham M. Al-Mekhlafi, Aymen M. Madkhali, Khalid Y. Ghailan, Ahmed A. Abdulhaq, Ahmad Hassn Ghzwani, Khalid Ammash Zain, Wahib M. Atroosh, Alkhansa Alshabi, Hussein A. Khadashi, Majid A. Darraj and Zaki M. Eisa

    Citation: Malaria Journal 2021 20:315

    Content type: Research

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  15. The entry of PCR-based techniques into malaria diagnostics has improved the sensitivity and specificity of the detection of Plasmodium infections. It has been shown that humans are regularly infected by at least ...

    Authors: Kim van Bergen, Toon Stuitje, Robert Akkers, Eric Vermeer, Rob Castel and Theo Mank

    Citation: Malaria Journal 2021 20:314

    Content type: Methodology

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  16. Prevalence of falciparum malaria on Bioko Island remains high despite sustained, intensive control. Progress may be hindered by high proportions of subpatent infections that are not detected by rapid diagnosti...

    Authors: Dianna E. B. Hergott, Jennifer E. Balkus, Guillermo A. García, Kurtis R. Cruz, Annette M. Seilie, Haley Masters, Akum A. Aveika, Marcos Mbuilto Iyanga, Jeremias Nzamio Mba Eyono, Brandon L. Guthrie and Sean C. Murphy

    Citation: Malaria Journal 2021 20:313

    Content type: Research

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  17. Red blood cell invasion by the Plasmodium vivax merozoite requires interaction between the Duffy antigen receptor for chemokines (DARC) and the P. vivax Duffy-binding protein II (PvDBPII). Given that the disrupti...

    Authors: Lemu Golassa, Alebachew Messele, Eniyou Cheryll Oriero and Alfred Amambua-Ngwa

    Citation: Malaria Journal 2021 20:312

    Content type: Research

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  18. Malaria patients can have two or more haplotypes in their blood sample making it challenging to identify which haplotypes they carry. In addition, there are challenges in measuring the type and frequency of re...

    Authors: Gie Ken-Dror and Pankaj Sharma

    Citation: Malaria Journal 2021 20:311

    Content type: Methodology

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  19. MOSKI KIT® is a fun tool designed to interest children for prevention and management of malaria. This study was carried out with the objective to assess the short- and long-term impacts of this tool on the kno...

    Authors: Isaac Akhénaton Manga, Aïssatou Gaye, Aliou Dia, Ekoue Kouevidjin, Maria Rosa Dos Reis, Aboubakry Sadikh Niang, Amy Ndao Fall, Christelle Maitre Anquetil and Jean Louis Abdourahim Ndiaye

    Citation: Malaria Journal 2021 20:310

    Content type: Research

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  20. Malaria blood-stage infection length and intensity are important drivers of disease and transmission; however, the underlying mechanisms of parasite growth and the host’s immune response during infection remai...

    Authors: Flavia Camponovo, Tamsin E. Lee, Jonathan R. Russell, Lydia Burgert, Jaline Gerardin and Melissa A. Penny

    Citation: Malaria Journal 2021 20:309

    Content type: Research

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  21. Vaccination with radiation-attenuated Plasmodium falciparum sporozoites is known to induce protective immunity. However, the mechanisms underlying this protection remain unclear. In this work, two recent radiatio...

    Authors: Fergal J. Duffy, Ying Du, Jason Carnes, Judith E. Epstein, Stephen L. Hoffman, Salim Abdulla, Said Jongo, Maxmillian Mpina, Claudia Daubenberger, John D. Aitchison and Ken Stuart

    Citation: Malaria Journal 2021 20:308

    Content type: Research

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  22. Point-of-care glucose-6-phosphate dehydrogenase (G6PD) testing has the potential to make the use of radical treatment for vivax malaria safer and more effective. Widespread use of G6PD tests as part of malaria...

    Authors: Emily Gerth-Guyette, Wondimagegn Adissu, Marcelo Brito, Eduardo Garbin, Marcela Macedo, Abhijit Sharma, Santasabuj Das, Marcus V. G. Lacerda, Dhélio Pereira, Arunansu Talukdar, Daniel Yilma, Sampa Pal, Stephanie Zobrist and Gonzalo J. Domingo

    Citation: Malaria Journal 2021 20:307

    Content type: Research

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  23. Even though malaria cases have drastically come down in the last decade, malaria remains a serious public health concern in many parts of India. National Framework for Malaria Elimination in India (2016–2030) ...

    Authors: Indumathi Mohan, Naveen Kumar Kodali, Savitha Chellappan, Balasubramani Karuppusamy, Sujit Kumar Behera, Gopalan Natarajan and Praveen Balabaskaran Nina

    Citation: Malaria Journal 2021 20:306

    Content type: Research

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  24. With the goal for malaria elimination in Thailand set for 2024, increased coverage and utilization of bed net, especially insecticide-treated net (ITN) or long-lasting insecticidal net (LLIN) is a key strategy...

    Authors: Kasama Pooseesod, Daniel M. Parker, Natthani Meemon, Saranath Lawpoolsri, Pratap Singhasivanon, Jetsumon Sattabongkot, Liwang Cui and Suparat Phuanukoonnon

    Citation: Malaria Journal 2021 20:305

    Content type: Research

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  25. Long-lasting insecticidal nets (LLINs) remain a cornerstone of malaria control, but strategies to sustain universal coverage and high rates of use are not well-defined. A more complete understanding of context...

    Authors: Claire M. Cote, Varun Goel, Rabbison Muhindo, Emmanuel Baguma, Moses Ntaro, Bonnie E. Shook-Sa, Raquel Reyes, Sarah G. Staedke, Edgar M. Mulogo and Ross M. Boyce

    Citation: Malaria Journal 2021 20:304

    Content type: Research

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  26. Plasmodium falciparum parasites cause malaria and co-exist in humans together with B-cells for long periods of time. Immunity is only achieved after repeated exposure. There has been a lack of methods to mimic th...

    Authors: Sreenivasulu B. Reddy, Noemi Nagy, Caroline Rönnberg, Francesca Chiodi, Allan Lugaajju, Frank Heuts, Laszlo Szekely, Mats Wahlgren and Kristina E. M. Persson

    Citation: Malaria Journal 2021 20:303

    Content type: Research

    Published on:

    The Publisher Correction to this article has been published in Malaria Journal 2021 20:323

  27. Malaria is still a major public health problem in sub-Saharan Africa and South-east Asia. The clinical presentations of malaria infection vary from a mild febrile illness to life-threatening severe malaria. To...

    Authors: Cho Naing, Siew Tung Wong and Htar Htar Aung

    Citation: Malaria Journal 2021 20:302

    Content type: Research

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  28. Malaria is a major health problem in Ethiopia. Sleeping under long-lasting insecticidal nets (LLINs) is its major control strategy. Despite high LLINs use (84%) in Ziway-Dugda District, malaria remained a publ...

    Authors: Mesfin Kelkile Wubishet, Gebretsadik Berhe, Alefech Adissu and Mesfin Segni Tafa

    Citation: Malaria Journal 2021 20:301

    Content type: Research

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  29. Although malaria in pregnancy is preventable with the use of intermittent preventive treatment with sulfadoxine–pyrimethamine (IPTp-SP), it still causes maternal morbidity and mortality, in sub-Saharan Africa ...

    Authors: Chijioke Ifeanyi Okoli, Mohammad Hajizadeh, Mohammad Mafizur Rahman and Rasheda Khanam

    Citation: Malaria Journal 2021 20:300

    Content type: Research

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  30. Cultured human red blood cells (RBCs) provide a powerful ex vivo assay platform to study blood-stage malaria infection and propagation. In recent years, high-resolution metabolomic methods have quantified hund...

    Authors: Shivendra G. Tewari, Krithika Rajaram, Russell P. Swift, Bobby Kwan, Jaques Reifman, Sean T. Prigge and Anders Wallqvist

    Citation: Malaria Journal 2021 20:299

    Content type: Research

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  31. Burundi has experienced an increase in malaria cases since 2000, reaching 843,000 cases per million inhabitants in 2019, a more than twofold increase compared to the early 2000s. Burundi thus contrasts the dec...

    Authors: Denis Sinzinkayo, Dismas Baza, Virgile Gnanguenon and Cristian Koepfli

    Citation: Malaria Journal 2021 20:298

    Content type: Review

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  32. Recent genome wide analysis studies have identified a strong association between single nucleotide variations within the human ATP2B4 gene and susceptibility to severe malaria. The ATP2B4 gene encodes the plasma ...

    Authors: Ana Villegas-Mendez, Nicholas Stafford, Michael J. Haley, Normalita Eka Pravitasari, Florence Baudoin, Adnan Ali, Puji Budi Setia Asih, Josephine E. Siregar, Esther Baena, Din Syafruddin, Kevin N. Couper and Delvac Oceandy

    Citation: Malaria Journal 2021 20:297

    Content type: Research

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  33. Ascariasis and malaria are highly prevalent parasitic diseases in tropical regions and often have overlapping endemic areas, contributing to high morbidity and mortality rates in areas with poor sanitary condi...

    Authors: Flaviane Vieira-Santos, Thaís Leal-Silva, Luiza de Lima Silva Padrão, Ana Cristina Loiola Ruas, Denise Silva Nogueira, Lucas Kraemer, Fabrício Marcus Silva Oliveira, Marcelo Vidigal Caliari, Remo Castro Russo, Ricardo Toshio Fujiwara and Lilian Lacerda Bueno

    Citation: Malaria Journal 2021 20:296

    Content type: Research

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  34. Plasmodium species are entirely dependent upon their host as a source of essential iron. Although it is an indispensable micronutrient, oxidation of excess ferrous iron to the ferric state in the cell cytoplasm c...

    Authors: Pragya Sharma, Veronika Tóth, Edel M. Hyland and Christopher J. Law

    Citation: Malaria Journal 2021 20:295

    Content type: Research

    Published on:

  35. In Mozambique, socio-economic and cultural factors influence the wide adoption of disease preventive measures that are relevant for malaria control strategies to promote early recognition of disease, prompt se...

    Authors: Liliana de Sousa Pinto, Jorge A. H. Arroz, Maria do Rosário O. Martins, Zulmira Hartz, Nuria Negrao, Victor Muchanga, Amadeu Cossa and Rose Zulliger

    Citation: Malaria Journal 2021 20:293

    Content type: Research

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  36. Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1.

    Authors: Marvin Duvalsaint, Melissa D. Conrad, Stephen Tukwasibwe, Patrick K. Tumwebaze, Jennifer Legac, Roland A. Cooper and Philip J. Rosenthal

    Citation: Malaria Journal 2021 20:292

    Content type: Research

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  37. In malaria endemic regions in Kenya, pregnant women are offered long-lasting insecticidal nets and intermittent preventive treatment (IPTp) with sulfadoxine–pyrimethamine (SP) at antenatal care (ANC) to preven...

    Authors: Jenna Hoyt, Jenny Hill, Florence Achieng, Peter Ouma, Simon Kariuki, Meghna Desai and Jayne Webster

    Citation: Malaria Journal 2021 20:291

    Content type: Research

    Published on:

  38. Surveillance data are essential for malaria control, but quality is often poor. The aim of the study was to evaluate the effectiveness of the novel combination of training plus an innovative quality improvemen...

    Authors: Nelli Westercamp, Sarah G. Staedke, Catherine Maiteki-Sebuguzi, Alex Ndyabakira, John Michael Okiring, Simon P. Kigozi, Grant Dorsey, Edward Broughton, Eleanor Hutchinson, M. Rashad Massoud and Alexander K. Rowe

    Citation: Malaria Journal 2021 20:290

    Content type: Research

    Published on:

  39. Demand for high-quality surveillance data for malaria, and other diseases, is greater than ever before. In Uganda, the primary source of malaria surveillance data is the Health Management Information System (H...

    Authors: Eleanor Hutchinson, Susan Nayiga, Christine Nabirye, Lilian Taaka, Nelli Westercamp, Alexander K. Rowe and Sarah G. Staedke

    Citation: Malaria Journal 2021 20:289

    Content type: Research

    Published on:

  40. Plasmodium vivax proteins with variant interspersed repeats (VIR) are the key proteins used by the parasite to escape from the host immune system through the creation of antigenic variations. However, few studies...

    Authors: Sanghyun Lee, Young-Ki Choi and Youn-Kyoung Goo

    Citation: Malaria Journal 2021 20:288

    Content type: Research

    Published on:

  41. Genus Anopheles mosquitoes are the primary vectors of human malaria, which is a serious threat to public health worldwide. To reduce the spread of malaria and identify the malaria infection rates in mosquitoes, a...

    Authors: Woo Jun Bang, Heung Chul Kim, Jihun Ryu, Hyeon Seung Lee, So Youn Lee, Myung Soon Kim, Sung Tae Chong, Terry A. Klein and Kwang Shik Choi

    Citation: Malaria Journal 2021 20:287

    Content type: Methodology

    Published on:

  42. Fifty-three percent of all cases of malaria in the Americas in 2019 came from Venezuela, where the epidemic is heavily focused south of the Orinoco river, and where most of the country’s Amerindian groups live...

    Authors: Juan C. Gabaldón-Figueira, Carlos Chaccour, Jorge Moreno, Maria Villegas and Leopoldo Villegas

    Citation: Malaria Journal 2021 20:285

    Content type: Research

    Published on:

  43. Travel is a well-recognized risk factor for malaria. Within sub-Saharan Africa, travellers from areas of lower to higher transmission intensity are potentially at high risk of malaria. Long-lasting insecticida...

    Authors: Deborah Ekusai-Sebatta, Emmanuel Arinaitwe, Arthur Mpimbaza, Joaniter I. Nankabirwa, Chris Drakeley, Philip J. Rosenthal, Sarah G. Staedke and Herbert Muyinda

    Citation: Malaria Journal 2021 20:283

    Content type: Research

    Published on:

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