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  1. The emergence of artemisinin-resistant malaria parasites highlights the need for novel drugs and their targets. Alkylation of purine bases can hinder DNA replication and if unresolved would eventually result i...

    Authors: Nattapon Pinthong, Paviga Limudomporn, Jitlada Vasuvat, Poom Adisakwattana, Pongruj Rattaprasert and Porntip Chavalitshewinkoon-Petmitr

    Citation: Malaria Journal 2020 19:284

    Content type: Research

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  2. Malaria control remains a challenge globally and in malaria-endemic countries in particular. In Rwanda, a citizen science programme has been set up to improve malaria control. Citizens are involved in collecti...

    Authors: Domina Asingizwe, P. Marijn Poortvliet, Arnold J. H. van Vliet, Constantianus J. M. Koenraadt, Chantal M. Ingabire, Leon Mutesa and Cees Leeuwis

    Citation: Malaria Journal 2020 19:283

    Content type: Research

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  3. Malaria in pregnancy is responsible for 8–14% of low birth weight and 20% of stillbirths in sub-Saharan Africa. To prevent these adverse consequences, the World Health Organization recommends intermittent prev...

    Authors: Julie R. Gutman, Daniel K. Stephens, Justin Tiendrebeogo, Ousmane Badolo, Mathurin Dodo, Danielle Burke, John Williamson, Kristen Vibbert, Susan J. Youll, Yacouba Savadogo and William R. Brieger

    Citation: Malaria Journal 2020 19:282

    Content type: Research

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  4. In the Greater Mekong sub-region, Plasmodium vivax has become the predominant species and imposes a major challenge for regional malaria elimination. This study aimed to investigate the variations in genes potent...

    Authors: Yan Zhao, Lin Wang, Myat Thu Soe, Pyae Linn Aung, Haichao Wei, Ziling Liu, Tongyu Ma, Yuanyuan Huang, Lynette J. Menezes, Qinghui Wang, Myat Phone Kyaw, Myat Htut Nyunt, Liwang Cui and Yaming Cao

    Citation: Malaria Journal 2020 19:281

    Content type: Research

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  5. Maternal malarial infection leads to poor perinatal outcomes, including low birth weight from preterm delivery and/or fetal growth restriction, particularly in primigravidas. In placental malaria, Plasmodium falc...

    Authors: Natalie M. Quanquin, Lauren G. Barres, Saba R. Aliyari, Nathan T. Day, Hoda Gerami, Susan J. Fisher, Abel Kakuru, Moses R. Kamya, Diane V. Havlir, Margaret Feeney, Grant Dorsey, Genhong Cheng and Stephanie L. Gaw

    Citation: Malaria Journal 2020 19:280

    Content type: Research

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  6. Policymakers have recognized that proprietary patent medicine vendors (PPMVs) can provide an opportunity for effective scaling up of artemisinin-based combination therapy (ACT) since they constitute a major so...

    Authors: Mary Y. Kodaolu, Adeniyi F. Fagbamigbe and IkeOluwapo O. Ajayi

    Citation: Malaria Journal 2020 19:279

    Content type: Research

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  7. Filtration of leukocytes (WBCs) is a standard practice of malaria ex vivo cultures. To date, few studies have considered the effect of filtration or the lack thereof on the survival of Plasmodium vivax ex vivo cu...

    Authors: Nicanor Obaldía III and Marlon Nuñez

    Citation: Malaria Journal 2020 19:278

    Content type: Research

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  8. At the beginning of 2019, a sudden surge of malaria cases was observed in the district of Riaba, Bioko Island. Between January and April, confirmed malaria cases increased 3.8-fold compared to the same period ...

    Authors: Carlos A. Guerra, Godwin Fuseini, Olivier Tresor Donfack, Jordan M. Smith, Teresa Ayingono Ondo Mifumu, Gninoussa Akadiri, Delicias Esono Mba Eyang, Consuelo Oki Eburi, Liberato Motobe Vaz, Victor Mba Micha, Leonor Ada Okenve, Christopher R. Janes, Ramona Mba Andeme, Matilde Riloha Rivas, Wonder P. Phiri, Michel A. Slotman…

    Citation: Malaria Journal 2020 19:277

    Content type: Case study

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  9. Malaria elimination efforts can be undermined by imported malaria infections. Imported infections are classified based on travel history.

    Authors: Rachel F. Daniels, Stephen F. Schaffner, Yakou Dieye, Gnagna Dieng, Michael Hainsworth, Fatou B. Fall, Coumba Ndoffene Diouf, Medoune Ndiop, Moustapha Cisse, Alioune Badara Gueye, Oumar Sarr, Philippe Guinot, Awa B. Deme, Amy K. Bei, Mouhamad Sy, Julie Thwing…

    Citation: Malaria Journal 2020 19:276

    Content type: Research

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  10. Malaria can be transmitted by blood transfusion through donations collected from asymptomatic donors. Transfusion-transmitted malaria (TTM) poses a great risk to blood services worldwide. A good screening tool...

    Authors: Daniele Rocha, Gisely Cardoso de Melo, José Marcelo Hipólito Carneiro, Marisa Ribeiro, Sthefanie Ribeiro, Daniela Tupy de Godoy, Anne Cristine Gomes de Almeida, Elisabete Ferreira de Andrade, Cláudia Maria de Moura Abrahim, Nelson Abrahim Fraiji, Antonio Gomes Pinto Ferreira, Wuelton Marcelo Monteiro, Rodrigo Brindeiro, Amilcar Tanuri, Marcus Vinicius Guimarães de Lacerda and Patrícia Alvarez

    Citation: Malaria Journal 2020 19:275

    Content type: Research

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  11. Severe complications among patients with Plasmodium malariae infection are rare. This is the first systematic review and meta-analysis demonstrating the global prevalence and mortality of severe P. malariae infec...

    Authors: Manas Kotepui, Kwuntida Uthaisar Kotepui, Giovanni D. Milanez and Frederick R. Masangkay

    Citation: Malaria Journal 2020 19:274

    Content type: Research

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  12. African houses are frequently too hot and uncomfortable to use a bed net at night. Indoor thermal comfort is often evaluated by measuring temperature and humidity, ignoring ventilation. This study explored way...

    Authors: Jakob B. Knudsen, Margaret Pinder, Ebrima Jatta, Musa Jawara, Mahamed A. Yousuf, Amalie T. Søndergaard and Steve W. Lindsay

    Citation: Malaria Journal 2020 19:273

    Content type: Research

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  13. Alternative long-lasting insecticidal net (LLIN) use for purposes other than sleeping protection from mosquitoes is widely debated as a limitation to successful malaria control efforts, yet rarely rigorously s...

    Authors: Ellen M. Santos, Jenna E. Coalson, Stephen Munga, Maurice Agawo, Elizabeth T. Jacobs, Yann C. Klimentidis, Mary H. Hayden and Kacey C. Ernst

    Citation: Malaria Journal 2020 19:272

    Content type: Research

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  14. Endemic Burkitt lymphoma (eBL) is an aggressive B cell non-Hodgkin lymphoma associated with antigenic stimulation from Plasmodium falciparum malaria. Whether eBL risk is related to malaria parasite density is unk...

    Authors: Lawrence S. Redmond, Martin D. Ogwang, Patrick Kerchan, Steven J. Reynolds, Constance N. Tenge, Pamela A. Were, Robert T. Kuremu, Nestory Masalu, Esther Kawira, Isaac Otim, Ismail D. Legason, Herry Dhudha, Leona W. Ayers, Kishor Bhatia, James J. Goedert and Sam M. Mbulaiteye

    Citation: Malaria Journal 2020 19:239

    Content type: Research

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  15. The Asia–Pacific region faces formidable challenges in achieving malaria elimination by the proposed target in 2030. Molecular surveillance of Plasmodium parasites can provide important information on malaria tra...

    Authors: Rintis Noviyanti, Olivo Miotto, Alyssa Barry, Jutta Marfurt, Sasha Siegel, Nguyen Thuy-Nhien, Huynh Hong Quang, Nancy Dian Anggraeni, Ferdinand Laihad, Yaobao Liu, Maria Endang Sumiwi, Hidayat Trimarsanto, Farah Coutrier, Nadia Fadila, Najia Ghanchi, Fatema Tuj Johora…

    Citation: Malaria Journal 2020 19:271

    Content type: Meeting report

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  16. Support supervision improves performance outcomes among health workers. However, the national professional guidelines for new licenses and renewal for Class C drug shops in Uganda prescribe self-supervision of...

    Authors: Arthur Bagonza, Henry Wamani, Stefan Peterson, Andreas Mårtensson, Milton Mutto, David Musoke, Freddy Eric Kitutu, David Mukanga, Linda Gibson and Phyllis Awor

    Citation: Malaria Journal 2020 19:270

    Content type: Research

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  17. High rates of dihydroartemisinin–piperaquine (DHA–PPQ) treatment failures have been documented for uncomplicated Plasmodium falciparum in Cambodia. The genetic markers plasmepsin 2 (pfpm2), exonuclease (pfexo) an...

    Authors: Nonlawat Boonyalai, Brian A. Vesely, Chatchadaporn Thamnurak, Chantida Praditpol, Watcharintorn Fagnark, Kirakarn Kirativanich, Piyaporn Saingam, Chaiyaporn Chaisatit, Paphavee Lertsethtakarn, Panita Gosi, Worachet Kuntawunginn, Pattaraporn Vanachayangkul, Michele D. Spring, Mark M. Fukuda, Chanthap Lon, Philip L. Smith…

    Citation: Malaria Journal 2020 19:269

    Content type: Research

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  18. Despite potent anti-malarial treatment, mortality rates associated with severe falciparum malaria remain high. To attempt to improve outcome, several trials have assessed a variety of potential adjunctive ther...

    Authors: Rosauro Varo, Clara Erice, Sydney Johnson, Quique Bassat and Kevin C. Kain

    Citation: Malaria Journal 2020 19:268

    Content type: Opinion

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  19. Health workers’ knowledge deficiencies about artesunate-based severe malaria treatment recommendations have been reported. However, predictors of the treatment knowledge have not been examined. In this paper, ...

    Authors: Beatrice Machini, Dejan Zurovac, Beatrice Amboko, Lucas Malla, Robert W. Snow, Hillary Kipruto and Thomas N. O. Achia

    Citation: Malaria Journal 2020 19:267

    Content type: Research

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  20. Cerebral malaria (CM), results from Plasmodium falciparum infection, and has a high mortality rate. CM survivors can retain life-long post CM sequelae, including seizures and neurocognitive deficits profoundly af...

    Authors: Nicoline Schiess, Andres Villabona-Rueda, Karissa E. Cottier, Katherine Huether, James Chipeta and Monique F. Stins

    Citation: Malaria Journal 2020 19:266

    Content type: Review

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  21. The present study provides a countrywide perspective of the malaria situation in Panamá over a long-term framework, with the purpose of identifying historical malaria resurgence events and their potential causes.

    Authors: Lisbeth Hurtado, Alberto Cumbrera, Chystrie Rigg, Milixa Perea, Ana María Santamaría, Luis Fernando Chaves, Dianik Moreno, Luis Romero, Jose Lasso, Lorenzo Caceres, Azael Saldaña and Jose E. Calzada

    Citation: Malaria Journal 2020 19:265

    Content type: Research

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  22. There have been an increasing number of imported cases of malaria in Hubei Province in recent years. In particular, the number of cases of Plasmodium ovale spp. and Plasmodium malariae significantly increased, wh...

    Authors: Jing Xia, Dongni Wu, Lingcong Sun, Hong Zhu, Kaijie Li, Juan Zhang, Wen Lin, Lun Wan, Huaxun Zhang and Si Liu

    Citation: Malaria Journal 2020 19:264

    Content type: Research

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  23. In the West African Sahel, mosquito reproduction is halted during the 5–7 month-long dry season, due to the absence of surface waters required for larval development. However, recent studies have suggested tha...

    Authors: Roy Faiman, Alpha S. Yaro, Moussa Diallo, Adama Dao, Samake Djibril, Zana L. Sanogo, Margery Sullivan, Asha Krishna, Benjamin J. Krajacich and Tovi Lehmann

    Citation: Malaria Journal 2020 19:263

    Content type: Research

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  24. Malaria is one of the main causes of death in Angola, particularly among children under 5 years of age. An essential means to improve the situation is with strong malaria case management; this includes diagnos...

    Authors: Sergio C. Lopes, Rukaaka Mugizi, João Esteves Pires, Fernando David, José Martins, Pedro Rafael Dimbu, Filomeno Fortes, Joana Rosário and Richard Allan

    Citation: Malaria Journal 2020 19:262

    Content type: Research

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  25. We have read the publication of Molina-Franky and colleagues on Plasmodium falciparum pre-erythrocytic stage vaccine development (Malaria Journal, 2020;19:56). The commentary revises some of their statements on t...

    Authors: François P. Roman, Margherita Coccia and Lode Schuerman

    Citation: Malaria Journal 2020 19:261

    Content type: Commentary

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  26. Plasmodium vivax malaria is characterized by the presence of dormant liver-stage parasites, called hypnozoites, which can cause malaria relapses after an initial attack. Primaquine, which targets liver hypnozoite...

    Authors: Alexandra Martin Ramírez, Carlos Lombardia González, Tamara Soler Maniega, Ángela Gutierrez Liarte, Diego Domingo García, Marta Lanza Suárez, María Josefa Bernal Fernández and José Miguel Rubio

    Citation: Malaria Journal 2020 19:259

    Content type: Case report

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  27. While Iran is on the path to eliminating malaria, the disease with 4.9 million estimated cases and 9300 estimated deaths in 2018 remains a serious health problem in the World Health Organization (WHO) Eastern ...

    Authors: Ahmadali Enayati, Ahmad Ali Hanafi-Bojd, Mohammad Mehdi Sedaghat, Morteza Zaim and Janet Hemingway

    Citation: Malaria Journal 2020 19:258

    Content type: Research

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  28. Unrestricted use of pesticides in agriculture is likely to increase insecticide resistance in mosquito vectors. Unfortunately, strategies for managing insecticide resistance in agriculture and public health se...

    Authors: Nancy S. Matowo, Marcel Tanner, Givemore Munhenga, Salum A. Mapua, Marceline Finda, Jürg Utzinger, Vera Ngowi and Fredros O. Okumu

    Citation: Malaria Journal 2020 19:257

    Content type: Research

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  29. In the absence of microscopy, Plasmodium falciparum histidine-rich proteins 2 (PfHRP2)-based rapid diagnostic tests (RDTs) are recommended for the diagnosis of falciparum malaria, particularly in endemic regions....

    Authors: Otchere Addai-Mensah, Bismarck Dinko, Mark Noagbe, Selassie Louis Ameke, Max Efui Annani-Akollor, Eddie-Williams Owiredu, Kofi Mensah, Richmond Tackie, Eliezer Togbe, Comfort Agyare-Kwabi, Charles Gyasi, Constance Adu-Gyamfi and Alexander Yaw Debrah

    Citation: Malaria Journal 2020 19:256

    Content type: Research

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  30. Artemisinin-based combination therapy (ACT) partner drugs, currently used in Ghana are lumefantrine, amodiaquine and piperaquine. Plasmodium falciparum isolates with reduced susceptibility to these partner drugs ...

    Authors: Peter Hodoameda, Nancy Odurowah Duah-Quashie, Charles Oheneba Hagan, Sena Matrevi, Benjamin Abuaku, Kwadwo Koram and Neils Ben Quashie

    Citation: Malaria Journal 2020 19:255

    Content type: Research

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  31. Malaria is one of the most prevalent infectious disease in the world with 3.2 billion humans at risk. Malaria causes splenomegaly and damage in other organs including skeletal muscles. Skeletal muscles compris...

    Authors: Mauro Toledo Marrelli, Zhiying Wang, Jian Huang and Marco Brotto

    Citation: Malaria Journal 2020 19:254

    Content type: Research

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  32. Plasmodium vivax resistance to chloroquine (CQ) has been reported from many endemic regions in the world. Plasmodium vivax is responsible for 95% of malaria cases in Afghanistan and CQ is the first-line treatment...

    Authors: Sayed Hussain Mosawi, Abdolhossein Dalimi, Najibullah Safi, Reza Fotouhi-Ardakani, Fatemeh Ghaffarifar and Javid Sadraei

    Citation: Malaria Journal 2020 19:253

    Content type: Research

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  33. Population-wide interventions using malaria testing and treatment might decrease the reservoir of Plasmodium falciparum infection and accelerate towards elimination. Questions remain about their effectiveness and...

    Authors: Ruben O. Conner, Yakou Dieye, Michael Hainsworth, Adama Tall, Badara Cissé, Farba Faye, Mame Demba Sy, Amadou Ba, Doudou Sene, Souleymane Ba, Elhadji Doucouré, Tidiane Thiam, Moussa Diop, Kammerle Schneider, Moustapha Cissé, Mady Ba…

    Citation: Malaria Journal 2020 19:252

    Content type: Research

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  34. Plasmodium vivax is the predominant Plasmodium species in Afghanistan. National guidelines recommend the combination of chloroquine and primaquine (CQ-PQ) for radical treatment of P. vivax malaria. Artesunate in ...

    Authors: Kasama Rakmark, Ghulam R. Awab, Jureeporn Duanguppama, Usa Boonyuen, Arjen M. Dondorp and Mallika Imwong

    Citation: Malaria Journal 2020 19:251

    Content type: Research

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  35. Extended artemisinin-based combination therapy (ACT) for treatment of uncomplicated Plasmodium falciparum malaria with already existing drug regimens, such as artemether-lumefantrine, might be effective in tackli...

    Authors: Lwidiko E. Mhamilawa, Sven Wikström, Bruno P. Mmbando, Billy Ngasala and Andreas Mårtensson

    Citation: Malaria Journal 2020 19:250

    Content type: Research

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  36. New classes of insecticides with novel modes of action, which can provide effective and prolonged control of insecticide-resistant malaria vector populations, are urgently needed for indoor residual spraying. ...

    Authors: Corine Ngufor, Augustin Fongnikin, Neil Hobbs, Martial Gbegbo, Laurette Kiki, Abibath Odjo, Martin Akogbeto and Mark Rowland

    Citation: Malaria Journal 2020 19:249

    Content type: Research

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  37. Recording behaviours that have the potential to impact health can be doubly challenging if the behaviour takes place in private spaces that cannot be observed directly, and where respondents answer what they t...

    Authors: Joe Brew, Margaret Pinder, Umberto D’Alessandro, Steven W. Lindsay, Caroline Jones and Elisa Sicuri

    Citation: Malaria Journal 2020 19:248

    Content type: Research

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  38. The production and use of malaria rapid diagnostic tests (RDTs) has risen dramatically over the past 20 years. In view of weak or non-existing in vitro diagnostics (IVD) regulations and post-marketing surveill...

    Authors: Sandra Incardona, David Bell, Ana Campillo, Jane Cunningham, Frederic Ariey, Thierry Fandeur, Jennifer Luchavez, Christian Anthony Luna, Didier Ménard, Sina Nhem, Johanna Beulah Sornillo, Benoit Witkowski, Zachary Katz, Sabine Dittrich and Xavier C. Ding

    Citation: Malaria Journal 2020 19:247

    Content type: Opinion

    Published on:

  39. Eighteen imported ovale malaria cases imported from Myanmar and various African countries have been reported in Yunnan Province, China from 2013 to 2018. All of them have been confirmed by morphological examin...

    Authors: Mengni Chen, Ying Dong, Yan Deng, Yanchun Xu, Yan Liu, Canglin Zhang and Herong Huang

    Citation: Malaria Journal 2020 19:246

    Content type: Research

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  40. Plasmodium falciparum circumsporozoite protein (PfCSP) is a potential malaria vaccine candidate, but various polymorphisms of the pfcsp gene among global P. falciparum population become the major barrier to the e...

    Authors: Hui-Ying Huang, Xue-Yan Liang, Li-Yun Lin, Jiang-Tao Chen, Carlos Salas Ehapo, Urbano Monsuy Eyi, Jian Li, Ting-Ting Jiang, Yu-Zhong Zheng, Guang-Cai Zha, Dong-De Xie, Jin-Quan He, Wei-Zhong Chen, Xiang-Zhi Liu, Huan-Tong Mo, Xin-Yao Chen…

    Citation: Malaria Journal 2020 19:245

    Content type: Research

    Published on:

  41. Current methods to classify local and imported malaria infections depend primarily on patient travel history, which can have limited accuracy. Genotyping has been investigated as a complementary approach to tr...

    Authors: Yaobao Liu, Sofonias K. Tessema, Maxwell Murphy, Sui Xu, Alanna Schwartz, Weiming Wang, Yuanyuan Cao, Feng Lu, Jianxia Tang, Yaping Gu, Guoding Zhu, Huayun Zhou, Qi Gao, Rui Huang, Jun Cao and Bryan Greenhouse

    Citation: Malaria Journal 2020 19:244

    Content type: Research

    Published on:

  42. An amendment to this paper has been published and can be accessed via the original article.

    Authors: April Monroe, Sarah Moore, Fredros Okumu, Samson Kiware, Neil F. Lobo, Hannah Koenker, Ellie Sherrard-Smith, John Gimnig and Gerry F. Killeen

    Citation: Malaria Journal 2020 19:243

    Content type: Correction

    Published on:

    The original article was published in Malaria Journal 2020 19:207

  43. Effective targeting and evaluation of interventions that protect against adult malaria vectors requires an understanding of how gaps in personal protection arise. An improved understanding of human and mosquit...

    Authors: April Monroe, Sarah Moore, Fredros Okumu, Samson Kiware, Neil F. Lobo, Hannah Koenker, Ellie Sherrard-Smith, John Gimnig and Gerry F. Killeen

    Citation: Malaria Journal 2020 19:207

    Content type: Opinion

    Published on:

    The Correction to this article has been published in Malaria Journal 2020 19:243

  44. Ghana has been implementing the indoor residual spraying (IRS) of insecticides since 2006, focusing operations in the north. Insecticide resistance concerns prompted a switch from pyrethroids to organophosphat...

    Authors: Christelle Gogue, Joseph Wagman, Kenzie Tynuv, Andrew Saibu, Yemane Yihdego, Keziah Malm, Wahjib Mohamed, Welbeck Akplu, Titus Tagoe, Anthony Ofosu, Ignatius Williams, Samuel Asiedu, Jason Richardson, Christen Fornadel, Laurence Slutsker and Molly Robertson

    Citation: Malaria Journal 2020 19:242

    Content type: Research

    Published on:

  45. Plasmodium knowlesi and Plasmodium vivax are the predominant Plasmodium species that cause malaria in Malaysia and play a role in asymptomatic malaria disease transmission in Malaysia. The diagnostic tools availa...

    Authors: Punitha Mahendran, Jonathan Wee Kent Liew, Amirah Amir, Xiao-Teng Ching and Yee-Ling Lau

    Citation: Malaria Journal 2020 19:241

    Content type: Research

    Published on:

  46. The efficacy of artemether-lumefantrine (AL) for treatment of uncomplicated Plasmodium falciparum malaria in south-western Ethiopia is poorly documented. Regular monitoring of drug efficacy is an important tool f...

    Authors: Abdulhakim Abamecha, Daniel Yilma, Wondimagegn Addisu, Hassan El-Abid, Achim Ibenthal, Harald Noedl, Delenasaw Yewhalaw, Mohieddine Moumni and Alemseged Abdissa

    Citation: Malaria Journal 2020 19:240

    Content type: Research

    Published on:

  47. Since 2014, seasonal malaria chemoprevention (SMC) with amodiaquine–sulfadoxine–pyrimethamine (AQ–SP) has been implemented on a large scale during the high malaria transmission season in Burkina Faso. This pap...

    Authors: Fabrice A. Somé, Thomas Bazié, Hanna Y. Ehrlich, Justin Goodwin, Aine Lehane, Catherine Neya, Kabré Zachari, Martina Wade, Jean-Marie Ouattara, Brian D. Foy, Roch K. Dabiré, Sunil Parikh and Jean-Bosco Ouédraogo

    Citation: Malaria Journal 2020 19:238

    Content type: Research

    Published on:

  48. Although Guyana has made significant progress toward malaria control, limited access to malaria testing and treatment services threatens those gains. Mining activities create breeding environments for mosquito...

    Authors: Shirley D. Yan, Jennifer Orkis, Saifra Khan Sohail, Sean Wilson, TrishAnn Davis and J. Douglas Storey

    Citation: Malaria Journal 2020 19:235

    Content type: Research

    Published on:

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