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  1. Malaria is a global health problem for which novel therapeutic compounds are needed. To this end, a recently published novel family of antiplasmodial macrolides, strasseriolides AD, was herein subjected to in vi...

    Authors: Frederick Annang, Guiomar Pérez-Moreno, Caridad Díaz, Victor González-Menéndez, Nuria de Pedro Montejo, José Pérez del Palacio, Paula Sánchez, Scott Tanghe, Ana Rodriguez, Ignacio Pérez-Victoria, Juan Cantizani, Luis M. Ruiz-Pérez, Olga Genilloud, Fernando Reyes, Francisca Vicente and Dolores González-Pacanowska

    Citation: Malaria Journal 2021 20:457

    Content type: Research

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  2. The World Health Organization (WHO) recommends prompt malaria diagnosis with either microscopy or malaria rapid diagnostic tests (RDTs) and treatment with an effective anti-malarial, as key interventions to co...

    Authors: Ruth N. Kigozi, JohnBaptist Bwanika, Emily Goodwin, Peter Thomas, Patrick Bukoma, Persis Nabyonga, Fred Isabirye, Paul Oboth, Carol Kyozira, Mame Niang, Kassahun Belay, Gloria Sebikaari, James K. Tibenderana and Sam Siduda Gudoi

    Citation: Malaria Journal 2021 20:456

    Content type: Research

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  3. Access to healthcare is important in controlling malaria burden and, as a result, distance or travel time to health facilities is often a significant predictor in modelling malaria prevalence. Adding new healt...

    Authors: Kok Ben Toh, Justin Millar, Paul Psychas, Benjamin Abuaku, Collins Ahorlu, Samuel Oppong, Kwadwo Koram and Denis Valle

    Citation: Malaria Journal 2021 20:455

    Content type: Research

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  4. Thailand is committed to eliminating malaria by 2024. From 2013 to 2020, the total number of malaria cases have decreased, from 37,741 to 4474 (an 88.1% reduction). However, infections with Plasmodium knowlesi, a...

    Authors: Rungniran Sugaram, Patcharida Boondej, Suttipat Srisutham, Chanon Kunasol, Watcharee Pagornrat, Usa Boonyuen, Arjen M Dondorp, Aungkana Saejeng, Prayuth Sudathip and Mallika Imwong

    Citation: Malaria Journal 2021 20:454

    Content type: Research

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  5. As part of malaria prevention and control efforts, the distribution and density of malaria mosquitoes requires continuous monitoring. Resources for long-term surveillance of malaria vectors, however, are often...

    Authors: Marilyn Milumbu Murindahabi, Arash Hoseni, L. C. Corné Vreugdenhil, Arnold J. H. van Vliet, Jackie Umupfasoni, Alphonse Mutabazi, Emmanuel Hakizimana, P. Marijn Poortvliet, Leon Mutesa, Willem Takken and Constantianus J. M. Koenraadt

    Citation: Malaria Journal 2021 20:453

    Content type: Research

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  6. RTS,S/AS01, the leading malaria vaccine has been recommended by the WHO for widespread immunization of children at risk. RTS,S/AS01-induced anti-CSP IgG antibodies are associated with the vaccine efficacy. Her...

    Authors: Robert M. Mugo, Kennedy Mwai, Jedidah Mwacharo, Faiz M. Shee, Jennifer N. Musyoki, Juliana Wambua, Edward Otieno, Philip Bejon and Francis M. Ndungu

    Citation: Malaria Journal 2021 20:452

    Content type: Research

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  7. The devastating public health impact of malaria has prompted the need for effective interventions. Malaria control gained traction after the introduction of artemisinin-based combination therapy (ACT). However...

    Authors: Afolabi Owoloye, Michael Olufemi, Emmanuel T. Idowu and Kolapo M. Oyebola

    Citation: Malaria Journal 2021 20:451

    Content type: Review

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  8. Malaria is a preventable disease that causes huge morbidity and mortality in malaria-endemic areas, especially among children and pregnant women. The malaria control programme focuses on the prevention of mosq...

    Authors: Verner N. Orish, Raymond Saa-Eru Maalman, Otchere Y. Donkor, Barbara Yordanis Henandez Ceruantes, Eric Osei, Hubert Amu, Prince Kubi Appiah, Kennedy Diema Konlan, Hadiru Mumuni, Eunji Kim, Siwoo Kim, Hajun Jung, Jones Ofori-Amoah, Philip Kofie, Martin Adjuik, Robert Kaba Alhassan…

    Citation: Malaria Journal 2021 20:450

    Content type: Research

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  9. The study aimed to analyse the likelihood of imported malaria in people with a suggestive clinical picture and its distinctive characteristics in a hospital in the south of Madrid, Spain.

    Authors: Alejandro Garcia-Ruiz de Morales, Covadonga Morcate, Elena Isaba-Ares, Ramon Perez-Tanoira and Jose A. Perez-Molina

    Citation: Malaria Journal 2021 20:449

    Content type: Research

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  10. In recent years, the incidence rate of vivax malaria recurrence still had 3.1% in Yunnan Province population after eradication therapy using primaquine (PQ). In order to understand the specific failure reasons...

    Authors: Ying Dong, Herong Huang, Yan Deng, Yanchun Xu, Mengni Chen, Yan Liu and Canglin Zhang

    Citation: Malaria Journal 2021 20:448

    Content type: Research

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  11. The return of chloroquine-sensitive Plasmodium falciparum in sub-Saharan Africa countries offers the opportunity for the reintroduction of chloroquine (CQ) either in combination with other drugs or as a single th...

    Authors: Kwame Kumi Asare, Justice Africa, Jennifer Mbata and Yeboah Kwaku Opoku

    Citation: Malaria Journal 2021 20:447

    Content type: Research

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  12. In the Greater Mekong Subregion, adults are at highest risk for malaria, particularly those who visit forests. The absence of effective vector control strategies and limited periods of exposure during forest v...

    Authors: Monnaphat Jongdeepaisal, Mom Ean, Chhoeun Heng, Thoek Buntau, Rupam Tripura, James J. Callery, Thomas J. Peto, Franca Conradis-Jansen, Lorenz von Seidlein, Panarasri Khonputsa, Kulchada Pongsoipetch, Ung Soviet, Siv Sovannaroth, Christopher Pell and Richard J. Maude

    Citation: Malaria Journal 2021 20:446

    Content type: Research

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  13. Plasmodium interspersed repeat (pir) is the largest multigene family in the genomes of most Plasmodium species. A variety of functions for the PIR proteins which they encode have been proposed, including antigeni...

    Authors: Timothy S. Little, Deirdre A. Cunningham, Audrey Vandomme, Carlos Talavera Lopez, Sarah Amis, Christopher Alder, John W. G. Addy, Sarah McLaughlin, Caroline Hosking, George Christophides, Adam J. Reid and Jean Langhorne

    Citation: Malaria Journal 2021 20:445

    Content type: Research

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  14. Malaria elimination in Brazil poses several challenges, including the control of Plasmodium falciparum foci and the hidden burden of Plasmodium vivax in pregnancy. Maternal malaria and fetal health outcomes were ...

    Authors: Julio Abel Seijas-Chávez, Melissa S. Nolan, Mary K. Lynn, Maria José Francalino da Rocha, Muana da Costa Araújo, Fernando Luiz Affonso Fonseca and Gabriel Zorello Laporta

    Citation: Malaria Journal 2021 20:444

    Content type: Research

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  15. Though most of Panamá is free from malaria, localized foci of transmission persist, including in the Guna Yala region. Government-led entomological surveillance using an entomological surveillance planning too...

    Authors: Mario I. Ávila, Élodie A. Vajda, Eileen Jeffrey Gutiérrez, Daragh A. Gibson, Mariela Mosquera Renteria, Nicholas Presley, Daniel O’Reilly, Timothy A. Burton, Allison Tatarsky and Neil F. Lobo

    Citation: Malaria Journal 2021 20:443

    Content type: Research

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  16. The histo-blood group ABO system has been associated with adverse outcomes in COVID-19, thromboembolic diseases and Plasmodium falciparum malaria. An integral part of the severe malaria pathogenesis is rosetting,...

    Authors: Pontus Hedberg, Madle Sirel, Kirsten Moll, Mpungu Steven Kiwuwa, Petter Höglund, Ulf Ribacke and Mats Wahlgren

    Citation: Malaria Journal 2021 20:441

    Content type: Research

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  17. In Sahelian Africa, the risk of malaria increases with the arrival of the rains, particularly in young children. Following successful trials, the World Health Organization (WHO) recommended the use of seasonal...

    Authors: Patrick O. Ansah, Nana A. Ansah, Keziah Malm, Dennis Awuni, Nana Peprah, Sylvester Dassah, Sobe Yarig, Charles Manful, John Agbenyeri, John Awoonor-Williams, Wilfred Ofosu and Abraham R. Oduro

    Citation: Malaria Journal 2021 20:440

    Content type: Research

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  18. The RTS,S/AS01 malaria vaccine is currently being evaluated in a cluster-randomized pilot implementation programme in three African countries. This study seeks to identify whether vaccination could reach addit...

    Authors: H. Juliette T. Unwin, Lazaro Mwandigha, Peter Winskill, Azra C. Ghani and Alexandra B. Hogan

    Citation: Malaria Journal 2021 20:438

    Content type: Research

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  19. Evidence on peer educators’ experiences of implementing the school-based educational interventions on malaria prevention would be used as inputs for malaria eliminating efforts. This study explored the accepta...

    Authors: Fira Abamecha, Alemayehu Deressa, Morankar Sudhakar, Lakew Abebe, Yohannes Kebede, Dejene Tilahun, Firanbon Teshome and Zewdie Birhanu

    Citation: Malaria Journal 2021 20:437

    Content type: Research

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  20. The currently used malaria vaccine, RTS,S, is designed based on the Plasmodium falciparum circumsporozoite protein (PfCSP). The pfcsp gene, besides having different polymorphic patterns, can vary between P. falci...

    Authors: Nouh Saad Mohamed, Hanadi AbdElbagi, Ahad R. Elsadig, Abdalla Elssir Ahmed, Yassir Osman Mohammed, Lubna Taj Elssir, Mohammed-Ahmed B. Elnour, Yousif Ali, Mohamed S. Ali, Omnia Altahir, Mustafa Abubakr, Emmanuel Edwar Siddig, Ayman Ahmed and Rihab Ali Omer

    Citation: Malaria Journal 2021 20:436

    Content type: Research

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  21. Chronic and frequently recurring infectious diseases, such as malaria, are associated with expanded populations of atypical memory B cells (MBCs). These cells are different from classical MBCs by the lack of s...

    Authors: S. Jake Gonzales, Sebastiaan Bol, Ashley E. Braddom, Richard Sullivan, Raphael A. Reyes, Isaac Ssewanyana, Erica Eggers, Bryan Greenhouse and Evelien M. Bunnik

    Citation: Malaria Journal 2021 20:435

    Content type: Research

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  22. The occurrence of artemisinin resistance (ART)-associated polymorphism of Plasmodium falciparum K13-propeller (pfk13) gene before and after the introduction of artemisinin-based combination therapy (ACT) in two r...

    Authors: Moses Ikegbunam, Johnson A. Ojo, Kossiwa Kokou, Ugonna Morikwe, Chukwuemeka Nworu, Chibuzo Uba, Charles Esimone, Thirumalaisamy P. Velavan and Olusola Ojurongbe

    Citation: Malaria Journal 2021 20:434

    Content type: Research

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  23. Insecticide-treated nets and indoor residual spraying of insecticides are used as the vector control interventions in the fight against malaria. Measuring the actual amount of deposits of insecticides on bed n...

    Authors: Harparkash Kaur, Elizabeth Louise Allan, Teunis A. Eggelte, Guillermo A. García and Feliciano Monti

    Citation: Malaria Journal 2021 20:433

    Content type: Research

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  24. Since 2005, artemisinin-based combination therapy (ACT) has been recommended to treat uncomplicated falciparum malaria in Madagascar. Artesunate-amodiaquine (ASAQ) and artemether-lumefantrine (AL) are the firs...

    Authors: Catherine M. Dentinger, Tovonahary Angelo Rakotomanga, Antsa Rakotondrandriana, Arinomenjanahary Rakotoarisoa, Marie Ange Rason, Leah F. Moriarty, Laura C. Steinhardt, Laurent Kapesa, Jocelyn Razafindrakoto, Samaly S. Svigel, Naomi W. Lucchi, Venkatachalam Udhayakumar, Eric S. Halsey and C. Arsène Ratsimbasoa

    Citation: Malaria Journal 2021 20:432

    Content type: Research

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  25. Although considerable success in reducing the incidence of malaria has been achieved in Brazil in recent years, an increase in the proportion of cases caused by the harder-to-eliminate Plasmodium vivax parasite c...

    Authors: Cleber Matos de Morais, Kayo Henrique de Carvalho Monteiro, Jose Diego Brito-Sousa, Wuelton Marcelo Monteiro, Vanderson Souza Sampaio, Patricia Takako Endo and Judith Kelner

    Citation: Malaria Journal 2021 20:431

    Content type: Research

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  26. Plasmodium sporozoites are the highly motile forms of malaria-causing parasites that are transmitted by the mosquito to the vertebrate host. Sporozoites need to enter and cross several cellular and tissue barrier...

    Authors: Konrad Beyer, Simon Kracht, Jessica Kehrer, Mirko Singer, Dennis Klug and Friedrich Frischknecht

    Citation: Malaria Journal 2021 20:430

    Content type: Research

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  27. Malaria causes significant mortality and morbidity in sub-Saharan Africa, especially among children under five years of age and places a huge economic burden on individuals and health systems. While this burde...

    Authors: Caroline Watts, Harrysone Atieli, Jason Alacapa, Ming-Chieh Lee, Guofa Zhou, Andrew Githeko, Guiyun Yan and Virginia Wiseman

    Citation: Malaria Journal 2021 20:429

    Content type: Research

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  28. The changing global health landscape has highlighted the need for more proactive, efficient and transparent health policy-making. After more than 60 years of limited development, novel tools for vivax malaria ...

    Authors: Varunika Ruwanpura, Josselyn Neukom, Koen Peeters Grietens, Ric N. Price, Kamala Thriemer and Caroline A. Lynch

    Citation: Malaria Journal 2021 20:428

    Content type: Research

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  29. Until recently, relatively little research has been done on how mosquitoes behave around the occupied bed net in the indoor environment. This has been partly remedied in the last few years through laboratory a...

    Authors: James F. Sutcliffe and Shaoman Yin

    Citation: Malaria Journal 2021 20:427

    Content type: Research

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  30. Plasmodium knowlesi, a simian malaria parasite infection, increases as Plasmodium falciparum and Plasmodium vivax infections decrease in Johor, Malaysia. Therefore, this study aimed to identify the distribution o...

    Authors: Sandthya Pramasivan, Romano Ngui, Nantha Kumar Jeyaprakasam, Jonathan Wee Kent Liew, Van Lun Low, Norzihan Mohamed Hassan, Wan Yusoff Wan Sulaiman, Ropiah Jaraee, Roslinda Abdul Rahman, Jenarun Jelip and Indra Vythilingam

    Citation: Malaria Journal 2021 20:426

    Content type: Research

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  31. Plasmodium falciparum is responsible for the vast majority of (severe) clinical malaria cases in most African settings. Other Plasmodium species often go undiagnosed but may still have clinical consequences.

    Authors: Daniel Ayo, Bakar Odongo, Joseph Omara, Chiara Andolina, Ole Mulder, Sarah G. Staedke and Teun Bousema

    Citation: Malaria Journal 2021 20:425

    Content type: Case report

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  32. Asymptomatic malaria infections largely remain undetected and act as a reservoir for continuous transmission. The study assessed the prevalence of submicroscopic asymptomatic malaria infections and anaemia in ...

    Authors: Paul M. Hayuma, Christian W. Wang, Edwin Liheluka, Vito Baraka, Rashid A. Madebe, Daniel T. R. Minja, Gerald Misinzo, Michael Alifrangis and John P. A. Lusingu

    Citation: Malaria Journal 2021 20:424

    Content type: Research

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  33. In rural sub-Saharan Africa, thatch roofs are being replaced by metal roofs. Metal roofing, however, increases indoor temperatures above human comfort levels, and thus makes it more likely that residents will ...

    Authors: Majo Carrasco-Tenezaca, Ebrima Jatta, Musa Jawara, John Bradley, Margaret Pinder, Umberto D’Alessandro, Jakob Knudsen and Steve W. Lindsay

    Citation: Malaria Journal 2021 20:423

    Content type: Research

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  34. Integrated community case management of malaria, pneumonia, and diarrhoea can reduce mortality in children under five years (CU5) in resource-poor countries. There is growing interest in expanding malaria comm...

    Authors: Dean Sayre, Laura C. Steinhardt, Judickaelle Irinantenaina, Catherine Dentinger, Tsinjo Fehizoro Rasoanaivo, Laurent Kapesa, Jocelyn Razafindrakoto, Agathe Legrand, Nicole Prada, Julie Gutman, Lauren Lewis, Reziky Tiandraza Mangahasimbola, Mauricette Andriamananjara, Aimée Vololoniala Ravaoarinosy, Nicolas Ralemary, Andres Garchitorena…

    Citation: Malaria Journal 2021 20:422

    Content type: Research

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  35. The emergence and spread of malaria drug resistance have resulted in the need to understand disease mechanisms and importantly identify essential targets and potential drug candidates. Malaria infection involv...

    Authors: Francis E. Agamah, Delesa Damena, Michelle Skelton, Anita Ghansah, Gaston K. Mazandu and Emile R. Chimusa

    Citation: Malaria Journal 2021 20:421

    Content type: Research

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  36. Health workers (HWs) appropriate malaria case management includes early detection and prompt treatment with appropriate anti-malarial drugs. Subsequently, HWs readiness and practice are considered authentic ev...

    Authors: Hosein Azizi, Reza Majdzadeh, Ayat Ahmadi, Elham Davtalab Esmaeili, Behrouz Naghili and Mohammad Ali Mansournia

    Citation: Malaria Journal 2021 20:420

    Content type: Research

    Published on:

  37. Malaria transmission is highly seasonal in Niger. Despite the introduction of seasonal malaria chemoprevention (SMC) in the Magaria District, malaria incidence remains high, and the epidemiology of malaria in ...

    Authors: Matthew E. Coldiron, Bachir Assao, Ousmane Guindo, Nathan Sayinzoga-Makombe, Alena Koscalova, Esther Sterk, Michel Quere, Iza Ciglenecki, Ann Mumina, Salifou Atti, Céline Langendorf and Rebecca F. Grais

    Citation: Malaria Journal 2021 20:419

    Content type: Research

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  38. The urban–rural designation has been an important risk factor in infectious disease epidemiology. Many studies rely on a politically determined dichotomization of rural versus urban spaces, which fails to capt...

    Authors: Peter S. Larson, Joseph N. S. Eisenberg, Veronica J. Berrocal, Don P. Mathanga and Mark L. Wilson

    Citation: Malaria Journal 2021 20:418

    Content type: Research

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  39. Haemosporidioses are common in birds and their manifestations range from subclinical infections to severe disease, depending on the involved parasite and bird species. Clinical haemosporidioses are often obser...

    Authors: Tanja Himmel, Josef Harl, Julia Matt and Herbert Weissenböck

    Citation: Malaria Journal 2021 20:417

    Content type: Research

    Published on:

  40. Although the association between malaria and anaemia is widely studied in patient cohorts, the population-representative causal effects of malaria on anaemia remain unknown. This study estimated the malaria-in...

    Authors: Tim Starck, Caroline A. Bulstra, Halidou Tinto, Toussaint Rouamba, Ali Sie, Thomas Jaenisch and Till Bärnighausen

    Citation: Malaria Journal 2021 20:416

    Content type: Research

    Published on:

  41. Supplementary tools are required to address the limitations of insecticide-treated nets (ITNs) and indoor residual spraying (IRS), which are currently the core vector control methods against malaria in Africa....

    Authors: Emmanuel W. Kaindoa, Arnold S. Mmbando, Ruth Shirima, Emmanuel E. Hape and Fredros O. Okumu

    Citation: Malaria Journal 2021 20:415

    Content type: Review

    Published on:

  42. Research on mosquito-microbe interactions may lead to new tools for mosquito and mosquito-borne disease control. To date, such research has largely utilized laboratory-reared mosquitoes that typically lack the...

    Authors: Nsa Dada, Ana Cristina Benedict, Francisco López, Juan C. Lol, Mili Sheth, Nicole Dzuris, Norma Padilla and Audrey Lenhart

    Citation: Malaria Journal 2021 20:414

    Content type: Research

    Published on:

  43. In cluster randomized trials (CRTs) or stepped wedge cluster randomized trials (SWCRTs) of malaria interventions, mosquito movement leads to contamination between trial arms unless buffer zones separate the cl...

    Authors: Lea Multerer, Fiona Vanobberghen, Tracy R. Glass, Alexandra Hiscox, Steven W. Lindsay, Willem Takken, Alfred Tiono and Thomas Smith

    Citation: Malaria Journal 2021 20:413

    Content type: Research

    Published on:

  44. Western Rajasthan in India has a typical desert climate. Until the introduction of the canal water irrigation system, malaria was an unstable and seasonal occurrence. Due to the scarcity of water, the communit...

    Authors: Himmat Singh, Sanjeev Kumar Gupta, Kumar Vikram, Rekha Saxena and Amit Sharma

    Citation: Malaria Journal 2021 20:412

    Content type: Research

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  45. Microscopic examination of thick and thin blood films is the gold standard in current guidelines for the diagnosis of malaria, but guidelines do not uniformly agree on which combination of other methods should...

    Authors: Marrit B. Boonstra, Rob Koelewijn, Eric A. T. Brienen, Welmoed Silvis, Foekje F. Stelma, Theo G. Mank, Bert Mulder, Lisette van Lieshout and Jaap J. van Hellemond

    Citation: Malaria Journal 2021 20:411

    Content type: Research

    Published on:

  46. The C580Y mutation in the Plasmodium falciparum kelch13 gene is the most commonly observed variant in artemisinin-resistant isolates in the Greater Mekong Subregion (GMS). Until 2017, it had not been identified o...

    Authors: Naoko Yoshida, Masato Yamauchi, Ryosuke Morikawa, Francis Hombhanje and Toshihiro Mita

    Citation: Malaria Journal 2021 20:410

    Content type: Research

    Published on:

  47. Standard treatment for both uncomplicated and severe malaria is artemisinin derivatives. Delayed parasite clearance times preceded the appearance of artemisinin treatment failures in Southeast Asia. Most world...

    Authors: Alexuse M. Saidi, Geoffrey Guenther, Rima Izem, Xiaojun Chen, Karl Seydel and Douglas Postels

    Citation: Malaria Journal 2021 20:408

    Content type: Research

    Published on:

  48. Malaria, pneumonia and diarrhoea continue to be the leading causes of death in children under the age of five years (U5) in Uganda. To combat these febrile illnesses, integrated community case management (iCCM...

    Authors: Patrick Lubogo, John Edward Lukyamuzi, Deo Kyambadde, Alex Aboda Komakech, Freddy Eric Kitutu and Edgar Mugema Mulogo

    Citation: Malaria Journal 2021 20:407

    Content type: Research

    Published on:

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